To reduce structural responses under earthquake excitations effectively and improve their resilience, a smart structure with a semiactive tuned mass damper (STMD) on the top story and a semiactive adjustable stiffness device (SASD) on the first story which contributes to the structural adaptive stiffness property is developed in this study. The SASD consists of a diamond spring device composed of four linear springs and an electromagnetic actuator, which can change the angle of the diamond device and therefore retune the stiffness. Two typical STMDs developed previously are reviewed first, which are diamond device‐based STMD with variable stiffness and damping and pendulum‐type STMD with variable frequency and eddy current damping, respectively. Numerical results show that the proposed STMD has a better control performance than passive‐tuned mass damper and STMD with variable stiffness or damping acting independently. To enhance the seismic protection of the structure with an STMD on the top story further, based on the principle of base isolation, a diamond device‐based SASD is applied to the first story. The linear quadratic Gaussian‐based variable stiffness algorithm for SASD is proposed. A 10‐story building is presented as a case study. The variable stiffness range of SASD is discussed in detail, while it is found that a ±50% variable stiffness range achieves the best earthquake mitigation. Control effects of different numbers of SASD implemented along the height of the building are compared as well. Numerical results show that with the increase in the number of SASDs, the earthquake mitigation effect is better; however, the magnitude of the increase is decreasing. The smart structure with the combined SASD and STMD has an excellent seismic protection performance and is better than with SASD or STMD acting independently. Meanwhile, it is found that the proposed combination has a similar control effect to four SASDs installed from the first story to the fourth story, respectively, while it can reduce the number of additional electromechanical systems and the influence on the use function of the building.