Mechanism and role of nuclear laminin B1 in cell senescence and malignant tumors
Tingcong Lv,
Cong Wang,
Jialin Zhou
et al.
Abstract:Nuclear lamin B1 (LMNB1) is a member of the nuclear lamin protein family. LMNB1 can maintain and ensure the stability of nuclear structure and influence the process of cell senescence by regulating chromatin distribution, DNA replication and transcription, gene expression, cell cycle, etc. In recent years, several studies have shown that the abnormal expression of LMNB1, a classical biomarker of cell senescence, is highly correlated with the progression of various malignant tumors; LMNB1 is therefore considere… Show more
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