Mechanism by which Alcohol and Wine Polyphenols Affect Coronary Heart Disease Risk

Booyse, François M.; Pan, Wensheng; Grenett, Hernan E.; Parks, Dale A.; Darley‐Usmar, Victor; Bradley, Kelley M.; Tabengwa, Edlue M.

doi:10.1016/j.annepidem.2007.01.006

Cited by 68 publications

(56 citation statements)

References 63 publications

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“…Earlier studies demonstrated that the beneficial effects of alcohol on cardiovascular disease may be mediated through raising high-density lipoprotein cholesterol [31], improving insulin sensitivity [32,33], raising plasma levels of adiponectin [34], inhibiting inflammation [35] and improving endothelial function [36], influencing platelet aggregation [37], other coagulation factors [38], fibrinolysis [3,39,40], and increasing plasma concentration of atrial natriuretic peptide (a cardiac hormone that plays a role in volume homeostasis) [14,41]. These multiple effects of alcohol could lower the risk of major risk factors for HF, including MI and type 2 diabetes mellitus.…”

Section: Physiologic Mechanisms Supporting Associations Between Modermentioning

confidence: 99%

Alcohol consumption and heart failure: A systematic review

Djoussé

Gaziano²

2008

Curr Atheroscler Rep

117

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Heart failure (HF) remains a major public health issue. It is estimated that about 500,000 Americans per year are diagnosed with HF. Despite advanced medical and surgical treatments for HF, mortality after the onset of HF is still high, thereby underscoring the importance of primary prevention. Among modifiable lifestyle factors, alcohol consumption appears to play a role in the development of HF. Although excessive drinking has been known to lead to alcoholic cardiomyopathy and light-tomoderate drinking may confer some cardiovascular benefits, recent studies suggest it is not only the quantity, but also drinking patterns and genetic factors, that may influence the relation between alcohol consumption and cardiovascular disease. This article reviews current evidence on the association between alcohol consumption and HF.

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Section: Physiologic Mechanisms Supporting Associations Between Modermentioning

confidence: 99%

Alcohol consumption and heart failure: A systematic review

Djoussé

Gaziano²

2008

Curr Atheroscler Rep

117

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“…6,7 Wine phenolic compounds have also been considered protective against diseases characterized by oxidative stress and inflammation. 8,9 However, little is known about their beneficial effects on intestinal function. 10,11 Phenolics are the most abundant non-alcoholic components of wine; their concentration and composition in wine depend on the grape varieties and winemaking processes employed.…”

Section: Introductionmentioning

confidence: 99%

The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics

et al. 2015

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Dietary oxysterols are cholesterol auto-oxidation products widely present in cholesterol-rich foods.They are thought to affect the intestinal barrier function, playing a role in gut inflammation. This study has characterized specific cell signals that are up-regulated in differentiated CaCo-2 colonic epithelial cells by a mixture of oxysterols representative of a hyper-cholesterolemic diet. p38 MAPK activation plays a major role, while other signal branches, i.e. the JNK and ERK pathways, make minor contributions to the intestinal inflammation induced by dietary oxysterols. p38 transduction might be the missing link connecting the known NADPH oxidase activation, and the induction of NF-κB-dependent inflammatory events related to oxysterols' action in the intestine. A NOX1/p38 MAPK/NF-κB signaling axis was demonstrated by the quenched inflammation observed on blocking individual branches of this signal with specific chemical inhibitors. Further, all these signaling sites were prevented when CaCo-2 cell were pre-incubated with phenolic compounds extracted from selected wines made of typical Sardinian grape varieties: red Cannonau and white Vermentino. Notably, Cannonau was more effective than Vermentino. The effect of Sardinian wine extracts on intestinal inflammation induced by dietary oxysterols might mainly be due to their phenolic content, more abundant in Cannonau than in Vermentino. Furthermore, among different phenolic components of both wines, epicatechin and caffeic acid exerted the strongest effects. These findings show a major role of the NOX1/p38 MAPK/NF-κB signaling axis in the activation of oxysteroldependent intestinal inflammation, and confirm the concept that phenolics act as modulators at different sites of pro-oxidant and pro-inflammatory cell signals.

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“…Since the observation of a lower mortality rate of coronary heart disease in France when compared to Northern European countries, known as the "French paradox" [1], a number of studies showed the health-promoting effects of phenolic compounds that are present in grapes and grape-derived products, including pure grape juice [2][3][4][5]. Consequently, there is a steady global rise of grape juice production over the last thirty years to fulfil a growing demand for pure grape juice by health-conscious consumers.…”

Section: Introductionmentioning

confidence: 99%

Characterization of an Antioxidant-Enriched Beverage from Grape Musts and Extracts of Winery and Grapevine By-Products

et al. 2018

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Abstract:The recovery of antioxidants from complex winery and grapevine by-products into Vitis vinifera must offers new opportunities for wine grapes by the development of a new, enriched fruit juice. However, this demands the search for new valorization methods to get hold of additional antioxidant compounds. The objective of this study was to find a novel functionality for grape pomace, grapevine leaves, and canes by its reuse as a functional matrix for the extraction of antioxidants into grape must. After thermomaceration, 22 polyphenols were identified by high performance liquid chromatography and mass spectrometry. Grape pomace was a good source of anthocyanins (malvidin-3-glucoside), while flavonols (quercetin-3-hexoside) and phenolic acids (caftaric acid) were the main phenolic compounds in leaf extracts. Catechin dimer was the only polyphenol compound present in all of the matrices. Enriched grape juice comprised by 40:20:40 (v/v/v) of pomace, leaf, and cane extracts, yielded an oxygen radical absorbance capacity of pirogallol red and fluorescein ratio of 0.70, indicating that the reactivity of antioxidants present in enriched grape juice was at least as efficient as other polyphenol-rich beverages. Thus, pomace, leaves and canes supply additional polyphenols to grape must that results into a beverage with promissory antioxidant activity and potential health benefits.

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Mechanism by which Alcohol and Wine Polyphenols Affect Coronary Heart Disease Risk

Cited by 68 publications

References 63 publications

Alcohol consumption and heart failure: A systematic review

Alcohol consumption and heart failure: A systematic review

The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics

Characterization of an Antioxidant-Enriched Beverage from Grape Musts and Extracts of Winery and Grapevine By-Products

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