Mechanism for human papillomavirus transmission at birth

Sedlacek, Thomas V.; Lindheim, Steven R.; Eder, Catherine; Hasty, Lisa A.; Woodland, Mark; Ludomirsky, A.; Rando, Robert F.

doi:10.1016/0002-9378(89)90232-9

Cited by 155 publications

(50 citation statements)

References 16 publications

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“…36 Postpartum, maternal-infant spread is suspected in the acquisition of laryngeal papillomatosis in infants born by vaginal delivery in mothers with genital condylomata, 68 a route of infection supported by detection of HPV DNA in nasopharyngeal aspirates of infants born by vaginal delivery in mothers with genital HPV infection. 69,70 In addition, maternal history of cervical dysplasia or anogenital warts strongly correlates with the acquisition of genital warts in infants and young children implicating maternal, not sexual, transmission of HPV infection in this age group. 71 Interestingly, HPV 2 dominates in genital warts in children.…”

Section: Discussionmentioning

confidence: 97%

Epidermodysplasia verruciformis–associated and genital-mucosal high-risk human papillomavirus DNA are prevalent in nevus sebaceus of Jadassohn

Carlson

Cribier

Nuovo

et al. 2008

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 97%

Epidermodysplasia verruciformis–associated and genital-mucosal high-risk human papillomavirus DNA are prevalent in nevus sebaceus of Jadassohn

Carlson

Cribier

Nuovo

et al. 2008

Journal of the American Academy of Dermatology

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“…However the actual HPV infection rate following vertical transmission is unknown, but assumed to be very low. With respect to sinonasal infection, HPV has been recovered from neonatal nasopharyngeal secretions of 47% of vaginally delivered babies with HPV positive mothers [48]. As infants become older, the rate of latent oral HPV infection decreases, therefore, latent neonatal infection is probably cleared or the viral load is reduced to undetectable levels.…”

Section: Latent Sinonasal Hpv Infection Is Rarementioning

confidence: 99%

The Role of the Human Papillomavirus in the Pathogenesis of Schneiderian Inverted Papillomas: An Analytic Overview of the Evidence

Lawson

Schlecht

Brandwein-Gensler

2008

Head and Neck Pathol

169

167

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We hypothesize that LR HPV may induce IP formation, and then are lost as infected cells are shed, as a "hit and run" phenomenon. HPV detection rates increase in dysplastic IP and SCC-ex-IP with increasing ratio of HR to LR HPV types, compared to nondysplastic IP. We believe that one explanation for the variation in HPV detection rates between different studies may be the actual histologic composition of the cohort. That is, if one series contains a higher frequency of dysplastic and malignant IP, it may have a higher detection rate than another series which contains only nondysplastic IP. We hypothesize that the higher rates of HPV detection in dysplastic and malignant IP may be related to HPV integration. The implication of this is that HPV sub-type testing may identify patients at risk for recurrence, or progression to dysplasia and malignancy, and thus may impact surveillance protocols.

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“…Perinatal transmission of HPV to neonates at birth has been detected in several studies [66,67]. In oral squamous cell specimens collected from 77 Japanese children aged 3 and 5 years, Kojima et al [68] found an overall 48.1% HPV positivity in normal mucosa of oral cavity.…”

Section: Modes Of Hpv Transmissionmentioning

confidence: 99%

Human papillomavirus in head and neck cancer: Molecular biology and clinicopathological correlations

Szentirmay¹,

Pólus

Tamás

et al. 2005

Cancer Metastasis Rev

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Human papillomaviruses are known to cause cancers of the cervix and other anogenital tract sites. Epidemiologic and molecular pathology studies have also suggested that HPV infection may be associated with cancers of the head and neck. Modes of transmission of HPV infection in the head and neck region have not been fully resolved; however, perinatal transmission and an association between sexual behavior and risk for HPV-positive cancers have been presented. Among the HPV types infecting the mucosa, high-risk, intermediate-risk and low-risk genotypes are defined, depending on their presence in carcinoma or precursor lesions. The phylogenic groups of HPVs also showed a definite correlation with the morphology of head and neck tumors. The groups A6, A7, and A9 include viruses that are frequently demonstrated in basaloid and verrucosus squamous cell carcinomas known to associate with HPV infection. Integration of HPV DNA into the host cell genome occurs early in cancer development and is an important event in malignant transformation. There is a trend for patients with HPV-positive tumors to be nondrinkers or light drinkers, the majority of these patients are females, and the median age is lower than in the case of HPV-negative tumors, but this latter difference was not always statistically significant. In the Kaplan-Meier survival model, the HPV-positive verrucous and basaloid squamous cell carcinomas showed better survival rates than the HPV-negative typical squamous cell carcinomas. An increased radiocurability of HPV-positive head and neck squamous cell carcinoma (HNSCC) has also been demonstrated.

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Mechanism for human papillomavirus transmission at birth

Cited by 155 publications

References 16 publications

Epidermodysplasia verruciformis–associated and genital-mucosal high-risk human papillomavirus DNA are prevalent in nevus sebaceus of Jadassohn

Epidermodysplasia verruciformis–associated and genital-mucosal high-risk human papillomavirus DNA are prevalent in nevus sebaceus of Jadassohn

The Role of the Human Papillomavirus in the Pathogenesis of Schneiderian Inverted Papillomas: An Analytic Overview of the Evidence

Human papillomavirus in head and neck cancer: Molecular biology and clinicopathological correlations

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