Mechanism investigation of fermented egg-milk peptides on colonic inflammatory diseases: based on in vivo and in silico research

Abstract

Fermented egg-milk beverage (FEMB) could alleviate the symptom of inflammatory diseases, but the underlying regulating mechanism of effective ingredients is unclear now. Our research was designed to confirm the protective...

Potential Benefits of Egg White Proteins and Their Derived Peptides in the Regulation of the Intestinal Barrier and Gut Microbiota: A Comprehensive Review

“…A significant decrease in the abundance of Verrucomicrobia and a significant increase in the abundance of Candidatus saccharimonas in colitis mice after gavage administration of 200 mg/kg of egg white peptides as previous studies reported . Similarly, egg white peptides prepared using microbial fermentation significantly increased the abundance of Lactobacillus in mice with colitis and significantly increased the level of SCFAs. , In addition, the tripeptides, IRW and IQW, identified in ovotransferrin hydrolysate, increased the richness of microbiota, normalized the F/B ratio, and decreased the relative abundance of Helicobacter in the mouse model. , …”

“…86 Similarly, egg white peptides prepared using microbial fermentation significantly increased the abundance of Lactobacillus in mice with colitis and significantly increased the level of SCFAs. 72,87 In addition, the tripeptides, IRW and IQW, identified in ovotransferrin hydrolysate, increased the richness of microbiota, normalized the F/B ratio, and decreased the relative abundance of Helicobacter in the mouse model. 105,127 Animal models and clinical studies have demonstrated the association between ecological dysregulation of the gut microbiota and obesity-related diseases.…”

“…Therefore, many studies have focused on hydrolysates and bioactive peptides of EWP to investigate the biological functions of these digests in vivo and in vitro. The main methods currently used to prepare egg white peptides include enzymatic digestion, microbial fermentation, and chemical synthesis. , Enzymatic hydrolysis is the main method used to produce EWP bioactive peptides and can be used to obtain peptides with various molecular weights. Wang et al identified three egg white peptides with DPP-IV inhibitory activity by simulating gastrointestinal digestion .…”

“…After the fermented egg milk beverage was administered by gavage to mice with colitis, the amino acid content in the mice recovered significantly and the number of goblet cells increased. In addition, digested fermented egg milk peptides can interact with inflammation-related targets, including the T cell receptor signaling pathway, indicating that egg white peptides may repair the intestinal barrier by supplementing the body with nutrients and increasing the content of amino acids in the body. , Although egg white hydrolysate has been widely studied at present, as a mixed protein, the component of egg white was complex and diverse, and its physiological function needs to be clarified with more purer proteins, which may be the future research direction.…”

A Comprehensive Review of Self-Assembled Food Protein-Derived Multicomponent Peptides: From Forming Mechanism and Structural Diversity to Applications

“…79 Moreover, research conducted by Li et al has demonstrated the synergistic anticancer potential of self-assembling amphiphilic α-la peptides when combined with curcumin. 80 Additionally, the self-assembled egg white peptides have been reported to possess notable antiinflammatory, 81 antioxidant, and wound-healing capabilities. 82 Kamal et al revealed that whey proteins hydrolyzed peptides exhibited potent antimicrobial activity against various pathogenic bacteria, inhibiting their growth and viability.…”