Mechanism of action of an Ir(<scp>iii</scp>) complex bearing a boronic acid active as a H<sub>2</sub>O<sub>2</sub>-responsive photosensitizer: ROS generation and quinone methide release for GSH scavenging

Barretta, Pierraffaele; Mazzone, Gloria

doi:10.1039/d3qi00203a

Inorg. Chem. Front.

2023

DOI: 10.1039/d3qi00203a

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Mechanism of action of an Ir(iii) complex bearing a boronic acid active as a H₂O₂-responsive photosensitizer: ROS generation and quinone methide release for GSH scavenging

Pierraffaele Barretta

Gloria Mazzone

Abstract: A DFT-based theoretical investigation is here reported to clarify the mechanism of action of a recently synthesized Ir(III) complex, Ir-B(OH)2, characterized by the presence of an aril boronic acid moiety...

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2024

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Cited by 2 publications

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A Pair of Deep Red Phosphorescent Responsive Emissive Cyclometalated Iridium (III) Complexes as Carbonic Anhydrase Inhibitor and Effective Theranostic Photosensitizer

Yang,

Wang,

Wang

et al. 2024

Applied Organom Chemis

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Herein, two deep red phosphorescent responsive emissive cyclometalated iridium (III) complexes with CAIX inhibition moiety was designed and synthesized; they can penetrate into living cells quickly and mainly located in the lysosome. They showed a strong binding affinity towards CAIX in vitro and effectively reduced cellular expression of CAIX. Moreover, the tethered CAIX‐inhibition moiety of benzene sulfonamide can decrease the inherent cytotoxicity of Ir(III) complex towards normal cells and improve killing selectivity towards cancer cells in dark; Ir3 and Ir4 exhibit approximately five to eight times higher killing selectivity than that of cisplatin; they exhibit satisfied photodynamic therapy effect under irradiation of 425 nm, ultimately resulting in apoptosis of cancer cell, which is accompanied with weakening of extracellular acidification, increased inhibition of cellular CAIX expression, significant loss of mitochondrial membrane potential, and elevated level of reactive oxygen. Herein, our work may demonstrate that combination of inhibition CAIX and metal photosensitizer may provide a promising strategy for constructing a novel theranostic platform.

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A Pair of Deep Red Phosphorescent Responsive Emissive Cyclometalated Iridium (III) Complexes as Carbonic Anhydrase Inhibitor and Effective Theranostic Photosensitizer

Yang,

Wang,

Wang

et al. 2024

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

Rational design by DFT calculations of new metal complexes for photodynamic therapy based on an H2O2-Responsive Ir(III) photosensitizer activatable in physiological environment

Barretta,

Ponte,

Mazzone

2024

Journal of Molecular Liquids

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Mechanism of action of an Ir(iii) complex bearing a boronic acid active as a H₂O₂-responsive photosensitizer: ROS generation and quinone methide release for GSH scavenging

Abstract: A DFT-based theoretical investigation is here reported to clarify the mechanism of action of a recently synthesized Ir(III) complex, Ir-B(OH)2, characterized by the presence of an aril boronic acid moiety...

Cited by 2 publications

References 85 publications

A Pair of Deep Red Phosphorescent Responsive Emissive Cyclometalated Iridium (III) Complexes as Carbonic Anhydrase Inhibitor and Effective Theranostic Photosensitizer

A Pair of Deep Red Phosphorescent Responsive Emissive Cyclometalated Iridium (III) Complexes as Carbonic Anhydrase Inhibitor and Effective Theranostic Photosensitizer

Rational design by DFT calculations of new metal complexes for photodynamic therapy based on an H2O2-Responsive Ir(III) photosensitizer activatable in physiological environment

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Mechanism of action of an Ir(iii) complex bearing a boronic acid active as a H2O2-responsive photosensitizer: ROS generation and quinone methide release for GSH scavenging

Abstract: A DFT-based theoretical investigation is here reported to clarify the mechanism of action of a recently synthesized Ir(III) complex, Ir-B(OH)2, characterized by the presence of an aril boronic acid moiety...

Cited by 2 publications

References 85 publications

A Pair of Deep Red Phosphorescent Responsive Emissive Cyclometalated Iridium (III) Complexes as Carbonic Anhydrase Inhibitor and Effective Theranostic Photosensitizer

A Pair of Deep Red Phosphorescent Responsive Emissive Cyclometalated Iridium (III) Complexes as Carbonic Anhydrase Inhibitor and Effective Theranostic Photosensitizer

Rational design by DFT calculations of new metal complexes for photodynamic therapy based on an H2O2-Responsive Ir(III) photosensitizer activatable in physiological environment

Contact Info

Product

Resources

About

Mechanism of action of an Ir(iii) complex bearing a boronic acid active as a H₂O₂-responsive photosensitizer: ROS generation and quinone methide release for GSH scavenging