Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system (Review)

Abstract

Tumors of the digestive system have always received attention, and their occurrence and development are regulated by various mechanisms such as inflammation and immunity, glucose and lipid metabolism, and tumor angiogenesis. Complement Clq/TNF-related protein 6 (CTRP6) is a member of the CTRP family; it is widely expressed in various tissues and cell types, and plays a biological role in a number of mechanisms, such as glucose and lipid metabolism and inflammation. Recent studies have revealed the tumor-promoting effect of CTRP6 in gastric cancer, liver cancer, colorectal cancer and other gastrointestinal tumors, but, to the best of our knowledge, there has been no systematic discussion on the tumor-promoting mechanism of CTRP6. The present study reviews the role of CTRP6 in tumors of the digestive system and its possible mechanisms.

Tumor-related factor complement Clq/TNF-related protein 6 affects the development of digestive system tumors through the phosphatidylinositol 3-kinase pathway

“…Inflammatory cytokines, such as IL-6, can activate the PI3K/Akt pathway, and CTRP6 may facilitate this process by promoting the secretion of these cytokines[ 12 ]. Additionally, CTRP6's role in glycolipid metabolism can indirectly affect the availability of substrates for the PI3K pathway, further fueling tumor growth[ 2 ]. In the realm of angiogenesis, a critical process for tumor growth and metastasis, CTRP6 has been shown to promote the formation of new blood vessels through the activation of proangiogenic factors, such as VEGF, via the PI3K/Akt pathway[ 13 ].…”

“…The complement C1q/TNF-related protein 6 (CTRP6) is a multifunctional protein that has been increasingly implicated in the pathogenesis of various digestive system tumors, including gastric, colorectal, and liver cancers[ 1 ]. The development of these tumors is a complex process influenced by genetic, environmental, and metabolic factors, with the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway emerging as a central regulator in this context[ 2 ].…”

Correlation of C1q/TNF-related protein-6 and irisin with type 2 diabetes mellitus

“…C1q/TNF-Related Proteins (CTRPs) are a family that has been found to be homologous to ADP, including 15 family members from CTRP1 to CTRP15. All CTRP members are secreted proteins and are widely expressed in various tissues and cells [3]. C1q/TNFα-related protein-6 (CTRP6) is a 29kDa adipocytokine consisting of four domains, including an amino-terminal signal peptide, a short variable domain, a collagen-like repeatable domain, and a carboxy-terminal complement C1q-like globular domain [4].…”

“…C1q/TNFα-related protein-6 (CTRP6) is a 29kDa adipocytokine consisting of four domains, including an amino-terminal signal peptide, a short variable domain, a collagen-like repeatable domain, and a carboxy-terminal complement C1q-like globular domain [4]. As a member of the CTRP family, CTRP6 is widely expressed in a variety of tissues and organs, including adipose tissue, heart, brain, and placenta, and it has been shown to play a role in fat metabolism, glucose metabolism, myocardial metabolism, inflammation, and autoimmunity [3,5].…”