Mechanism of Action of Mitomycins

Biosynthesis

“…A related ring system, an azirine ring, occurs in the Streptomyces aureus antibiotic azirinomycin (IV) (MILLER et ai., 1971). The mode of action of the mitomycins has been reviewed by SZYBALSKI and IYER (1967), and more recently by KERSTEN (1975). The mode of action of the mitomycins has been reviewed by SZYBALSKI and IYER (1967), and more recently by KERSTEN (1975).…”