Mechanism of Action of Pyrogenic and Antipyretic Steroids
            <i>in vitro</i>

Bondy, Philip K.; Bodel, Phyllis

doi:10.1002/9780470719800.ch6

Cited by 17 publications

(8 citation statements)

References 10 publications

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“…Corticosteroids have been shown to cause the suppression of fever caused by various etiologies, including allergic reactions, collagen vascular diseases, infections, and malignancy [10,22,25,28,40]. The antipyretic effect of corticosteroids on neoplastic fever was compared to that of naproxen [16].…”

Section: Defining Neoplastic Fevermentioning

confidence: 99%

Neoplastic fever: a neglected paraneoplastic syndrome

Zell

Chang

2005

Support Care Cancer

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Neoplastic fever, a paraneoplastic syndrome caused by cancer itself, represents a diagnostic challenge for the clinician and is an important issue in supportive oncology. Timely recognition of this febrile condition by differentiating it from other cancer-associated fevers, such as infection and drug reaction, is essential for effective patient management. Although the pathophysiology of neoplastic fever is not well understood, it is suspected to be cytokine mediated. In clinical practice, when a patient with cancer presents with unexplained fever, extensive diagnostic studies are needed to differentiate neoplastic fever from nonneoplastic fever. Only after excluding identifiable etiologies of fever can the diagnosis of neoplastic fever be suspected. According to our experience, the naproxen test is a safe and useful test in differentiating neoplastic fever from infectious fever in patients with cancer. In addition, naproxen and other nonsteroidal anti-inflammatory drugs have been effective in the management of neoplastic fever and offer a significant palliative benefit for the patient.

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Section: Defining Neoplastic Fevermentioning

confidence: 99%

Neoplastic fever: a neglected paraneoplastic syndrome

Zell

Chang

2005

Support Care Cancer

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“…Cooper et al (1967) propose that a fever induced centrally by endotoxin may be due to the production of endogenous pyrogen by leucocytes that infiltrate into the area of the injection from the systemic circulation, because after an infusion of a bacterial pyrogen into the hypothalamus of the rabbit, a significant number of polymorphonuclear leucocytes were identified at the site of injection. The prolonged action of pyrogen in the monkey could thus be explained by the fact that polymorphonuclear cells, once 'activated', continue to produce leucocyte pyrogen for many hours after the initial activating substance dissipates (Bondy & Bodel, 1971). Although it is puzzling how a pyrogen-free solution of saline or artificial c.s.f.…”

Section: Discussionmentioning

confidence: 99%

Fever produced by endotoxin injected into the hypothalamus of the monkey and its antagonism by salicylate

Myers¹,

Rudy²,

Yaksh³

1974

The Journal of Physiology

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SUMMARY1. A suspension of the killed cell bodies of either E. coli, S. dysenteriae or S. typhosa was micro-injected through cannulae implanted chronically at specific sites within the diencephalon and mid-brain of the unanaesthetized monkey. A biphasic, monophasic or an undifferentiated fever could be induced by each type of micro-organism, but the type of response depended solely upon the locus of injection.2. Although little difference in the potency of the three pyrogens was found, the rise in body temperature was in each instance dependent upon the concentration of the endotoxin. A more intense fever was accompanied by shivering, vasoconstriction of the ear vessels, piloerection and huddling behaviour. Tolerance to the pyrexic effect of repeated injections of endotoxin did not develop.3. The febrile response having the shortest latency, greatest maximum rise in temperature and largest 10-hr fever index was evoked by microinjections into the anterior hypothalamic, preoptic area. The incidence of biphasic fevers was also greater after endotoxin was injected into this same region. Endotoxin given similarly in the posterior hypothalamus or in the mesencephalon had either no effect or produced a smaller elevation in temperature after a longer latency. The distance of an injection site from the coronal plane formed by the optic chiasm and anterior commissure correlated significantly with the latency and magnitude of the temperature change as well as the fever index.4. When given intravenously, endotoxin in a quantity at least 100 times greater was required to evoke a fever similar to that produced when the pyrogen was micro-injected into the anterior hypothalamic, preoptic region. However, a biphasic fever was evoked with a latency of * Present address:

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“…However, PGE2 (and perhaps other cyclooxygenase products) are not re quired for macrophage activation or IL-1 production since the addition of cyclooxy genase inhibitors before and during produc tion have no effect [46][47][48]. Corticosteroids suppress EP [49] and LAF production [50], although other studies have shown that methyl-prednisolone has no effect [51]. Cy closporin A has been reported to have no effect on LAF production [51].…”

Section: Inducers O F Il-1 Productionmentioning

confidence: 99%

The Biology of Interleukin-1 and Its Relevance to Hemodialysis

Dinarello¹

1983

Blood Purif

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The host responds to infectious, toxic inflammatory and immunological challenges with a remarkably consistent set of changes which are often grouped together and called the acute phase response. This response includes fever, negative nitrogen balance, increased synthesis of certain hepatic proteins, decreases in plasma iron and zinc levels and increases in circulating neutrophils. The continued presence of the disease results in the persistence of acute phase changes such that these changes can also be markers of a chronic pathological process. The ability of the host to produce several components of the acute phase response is due to the synthesis and release of a mediator peptide derived from activated mononuclear phagocytes and now called interleukin-1 (IL-1). Many of the clinical and laboratory changes noted in chronic hemodialysis are indicative of an acute phase response and are probably mediated by IL-1. This review considers the production and biological properties of IL-1 and the role of this mediator in host responses. In addition, particular attention is paid to the importance of monocyte activation and IL-1 release which may be a consequence of hemodialysis.

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Mechanism of Action of Pyrogenic and Antipyretic Steroids in vitro

Cited by 17 publications

References 10 publications

Neoplastic fever: a neglected paraneoplastic syndrome

Neoplastic fever: a neglected paraneoplastic syndrome

Fever produced by endotoxin injected into the hypothalamus of the monkey and its antagonism by salicylate

The Biology of Interleukin-1 and Its Relevance to Hemodialysis

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