Mechanism of active acetylcholinesterase inhibition by organic sulfanes in garlic: Non-covalent binding and covalent modifications

Zhu, Yanwen; Shi, Dandan; Chen, Ao; Wang, Yanqun; Liu, Ling; Bai, Bing

doi:10.1016/j.ijbiomac.2023.124972

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…Diallyl disulfide (DADS) is a compound consisting of two allyl groups attached to two sulfur atoms and constitutes 40-60% of garlic oil. DADS is produced during the decomposition of allicin and has been extensively studied regarding its medicinal value [13,14]. In recent years, a large number of studies revealed that DADS has important significance in anti-tumor, antioxidant, antibacterial, anti-inflammatory, immune enhancement, lowering blood lipids, and anti-platelet agglutination, etc [15,16].…”

Section: Abstract: Dads、marek's Disease、migration and Invasion、nf-κb、...mentioning

confidence: 99%

Inhibition of MSB-1 cell invasion and migration by Diallyl disulfide(DADS) through NF-κB signaling pathway

Liu,

Li,

Liu

et al. 2023

Preprint

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Marek's disease is a lymphoproliferative disorder in chickens characterized by monocyt Marek's disease ic infiltration of single or multiple tissues and organs of peripheral nerves, gonads, iris, various internal organs, muscles, and skin. This disease is an infectious neoplastic disease caused by cell-bound herpesvirus, which causes the formation of tumors in the above organs and tissues. Sick chickens are commonly emaciated, paralyzed, and often have acute death. To investigate the effect of diallyl disulfide (DADS) on the migration and invasion of MSB-1 cells and explore its mechanism, to lay the foundation for the study of invasion and migration of tumor cells in chicken Malik's disease. To investigate the roles of DADS on the migration and invasion of MSB-1 cells, different concentrations of DADS (0,30,90,120 µmol/L) on the growth and proliferation of MSB-1 cells was analyzed by CCK8 assay. Cell migration and invasion were detected by Transwell assays. Protein activity of related proteins MMP2 and MMP9 were detected by gelatinase profiling; the expression of related proteins NF-κB, MMP2, MMP9, VEGF, E-cadherin and Vimentin were detected by ELISA. DADS significantly inhibited the migration and invasion of MSB-1 cells and altered the morphological structure of the cells. Through data analysis, it can be concluded that the concentration of 30µmol/L DADS significantly inhibits the migration and invasion of cells, and the concentration of DADS of 60µmol/L and 90 µmol/L highly significantly inhibits the migration and invasion of cells. The expressions of migration and invasion-related proteins NF-κB, MMP2, MMP9, VEGF, E-cadherin and Vimentin were decreased in a dependent manner with increasing DADS concentration. DADS may reduce the degradation of the extracellular matrix by inhibiting the expression of MMP2 and MMP9 through suppressing the NF-κB signaling pathway, and at the same time. Might be inhibit angiogenesis by decreasing the expression of VEGF, thus inhibiting the migration and invasion of MSB-1 cells.

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Section: Abstract: Dads、marek's Disease、migration and Invasion、nf-κb、...mentioning

confidence: 99%

Inhibition of MSB-1 cell invasion and migration by Diallyl disulfide(DADS) through NF-κB signaling pathway

Liu,

Li,

Liu

et al. 2023

Preprint

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show abstract

Pharmacological assessment of disulfide–triazine hybrids: synthesis, enzyme inhibition, and molecular docking study

Türkan,

Cetin,

Rozbicki

et al. 2024

Med Chem Res

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AChE activity self-breathing control mechanisms regulated by H2Sn and GSH: Persulfidation and glutathionylation on sulfhydryl after disulfide bonds cleavage

Zhu,

Hu,

Liu

et al. 2024

International Journal of Biological Macromolecules

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Mechanism of active acetylcholinesterase inhibition by organic sulfanes in garlic: Non-covalent binding and covalent modifications

Cited by 4 publications

References 37 publications

Inhibition of MSB-1 cell invasion and migration by Diallyl disulfide(DADS) through NF-κB signaling pathway

Inhibition of MSB-1 cell invasion and migration by Diallyl disulfide(DADS) through NF-κB signaling pathway

Pharmacological assessment of disulfide–triazine hybrids: synthesis, enzyme inhibition, and molecular docking study

AChE activity self-breathing control mechanisms regulated by H2Sn and GSH: Persulfidation and glutathionylation on sulfhydryl after disulfide bonds cleavage

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