Mechanism of acute lung injury caused by inhalation of fabric protector and the effect of surfactant replacement

Abstract

Impairment of surfactant is a factor involved in the development of acute lung injury caused by inhalation of fabric protector. Surfactant replacement may be therapeutic for such injuries.

An in vitro method for predicting inhalation toxicity of impregnation spray products

“…Thus, Tashiro et al (1998) used surfactant isolated from pigs and extracted with organic solvents in the pulsating bubble surfactometer to show the effects of a fabric protector on pulmonary surfactant. This effect was linked to the toxicity of the product in rats, and the affected rats could subsequently be rescued by introducing exogenous surfactant to the lungs (Tashiro et al, 1998). Fisher et al (2012) used an isolated perfused rat lung model to assess the effect of waterproofing sprays.…”

An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function

“…Respiratory symptoms following exposure to airborne substances (chemicals or particles) are reported regularly. In private homes, impregnation products are among the most commonly reported triggers of such symptoms ( Lazor-Blanchet et al, 2004 , Vernez et al, 2006 , Khalid et al, 2009 , Scheepers et al, 2017 , Tashiro et al, 1998 , Duch et al, 2014 , Laliberté et al, 1995 , Burkhart et al, 1996 , Malik and Chappell, 2003 ). In occupational settings, respiratory clinical signs of toxicity have been observed after workers’ exposure to cleaning products ( Clausen et al, 2020 , Medina-Ramon et al, 2006 , Vizcaya et al, 2015 ) and pesticides ( Slavica et al, 2018 ), among others.…”

Acute Inhalation Toxicity After Inhalation of ZnO Nanoparticles: Lung Surfactant Function Inhibition In Vitro Correlates With Reduced Tidal Volume in Mice

“…If the minimum surface tension of the LS reaches this value, atelectasis will start to occur. 21 Therefore, particles increasing the minimum surface tension of LS above 10 mN/m (both mean and lower 95% confidence limit above 10 mN/m) were considered as inhibitory to LS function.…”