Mechanism of anaemia in resistant visceral leishmaniasis

Pippard, M. J.; Moir, D. J.; Weatherall, D. J.; Lenicker, Herbert Manfred

doi:10.1080/00034983.1986.11812022

Cited by 27 publications

(23 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Blood volume determinations using radioiron 59 Fe and radio-chromium 51 Cr have evidenced normal values 17 . On the other side, expanded intravascular volume has been extensively documented using T-1824 dye method, in patients with splenomegaly and visceral leishmaniasis 23,31 .…”

Section: Discussionmentioning

confidence: 99%

Hyponatremia in visceral leishmaniasis

Verde

Veronese

et al. 2010

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYThere are few reports linking hyponatremia and visceral leishmaniasis (kala-azar). This is a study of 55 consecutive kala-azar patients and 20 normal individuals as a control group. Hyponatremia and serum hypo-osmolality were detected in 100% of kalaazar patients. High first morning urine osmolality (750.0 ± 52.0 vs. 894.5 ± 30.0mOsm/kg H 2 O, p < 0.05), and high 24-hour urine osmolality (426.0 ± 167.0 vs. 514.6 ± 132.0 mOsm/kg H 2 O, p < 0.05) demonstrated persistent antidiuretic hormone secretion. Urinary sodium was high (82.3 ± 44.2 vs.110.3 ± 34.7 mEq/L, p < 0.05). Low seric uric acid occurred in 61.8% of patients and increased fractional urinary uric acid excretion was detected in 74.5% of them. Increased glomerular filtration rate was present in 25.4% of patients. There was no evidence of extracellular volume depletion. Normal plasma ADH levels were observed in kala-azar patients. No endocrine or renal dysfunction was detected. It is possible that most hyponatremic kala-azar patients present the syndrome of inappropriate antidiuretic hormone secretion.

show abstract

Section: Discussionmentioning

confidence: 99%

Hyponatremia in visceral leishmaniasis

Verde

Veronese

et al. 2010

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

show abstract

“…Various mechanisms of red cell destruction have been suggested by researchers including splenic sequestration, increased sensitivity to complement, changes in erythrocyte enzymes resulting in change in red cell membrane permeability, and presence of cold agglutinins. (14,15) Deficiencies of iron, folate and vitamin B12 may also have some additional role. (16) Studies have not shown any role of ineffective erythropoiesis in development of anemia in these patients.…”

Section: Hematological Changes Seen In Vlmentioning

confidence: 99%

Hematological changes in Visceral Leishmaniasis

Neki¹,

Singh²

2017

Int. J. Curr. Res. Med. Sci.

View full text Add to dashboard Cite

Visceral Leshmaniais (VL) is caused by Leshmania donovani, and is transmitted by the bite of female phlebotomine sandfly. This disease is widely prevalent in the world, and is endemic in a few states of India. Clinical features of this disease include fever, anemia, weight loss, lymphadenopathy, hepatosplenomegaly. Hematological features in VL include anemia, neutropia, lymphocytosis and thrombocytopenia. Bone marrow examination shows reticuloendothelial cell hyperplasia, erythroid hyperplasia, reduction of neutrophils, eosinophic myelocytes and plasma cells. The ratio of granulocytes to non-granulocytes is decreased. The ability of megakaryocyes to form platelets is also decreased.

show abstract

“…The prevalence of anemia in Visceral Leishmaniasis patients occur mostly, because of several factor include hemolytic, chronic disease, opportunistic infection, and certain nutritional deficiencies. Hemolysis is the major cause of anemia this problem [11,12] though there may also be plasma volume expansion associated with massively enlarged spleen. The reticuloendothelial hyperplasia limits the bone marrow response to hemolysis [18].…”

Section: Statement Of the Problemmentioning

confidence: 99%

“…From Visceral Leishmaniasis related hematological abnormalities, anemia is the most common abnormalities [9,10]. Its cause is multifactorial; sequestration and destruction of red blood cells in large spleen, immune mechanism and alteration in blood RBC membrane permeability [11,12].…”

Section: Introductionmentioning

confidence: 99%

Haematological Abnormalities in <i>Visceral Leishmaniasis</i> Patients Attending Gondar University Hospital; Retrospective Study

Tesfaye¹

2017

IJHPEBS

View full text Add to dashboard Cite

Abstract:Visceral Leishmaniasis (VL) or kalazar is a fatal neglected tropical disease caused by protozoan parasites of the genus Leishmania, belonging to the family Trypanosomatidae. Leishmania donovani complex are the causative agents of Visceral Leishmaniasis in Ethiopia and its burden is a public health problem where every year health facilities report thousands of cases and hundreds of deaths. Hematological abnormalities are the common presentation for human with Visceral Leishmaniasis, which comprises anemia, leucopenia and thrombocytopenia. Therefore; this study aimed to assess hematological abnormalities among Visceral Leishmaniasis patients attending Gondar University Hospital using a cross sectional study design. Socio-demographic data on 414 Visceral Leishmaniasis patients having complete records on hematological parameters collected from the laboratory log book and hospital chart by using a structured data collection sheet. Data was entered and analyze by using SPSS version 20. From the total 414 Visceral Leishmaniasis patients, 405(97.8%) were males and 9(2.2%) were females. The overall magnitude of anemia, leucopenia, thrombocytopenia, neutropenia and Lymphopenia was 94.4%, 95.4%, 90.1%, 90.1% and 37.9% respectively. There was a significant association between age and prevalence of anemia, neutropenia and thrombocytopenia. The finding of the study shows with predominant existence of anemia, leucopenia and thrombocytopenia. Thus, specific diagnosis and monitoring of hematological abnormalities is required for early treatment of the disease and decreases mortality rate due to these abnormalities.

show abstract

Mechanism of anaemia in resistant visceral leishmaniasis

Cited by 27 publications

References 8 publications

Hyponatremia in visceral leishmaniasis

Hyponatremia in visceral leishmaniasis

Hematological changes in Visceral Leishmaniasis

Haematological Abnormalities in <i>Visceral Leishmaniasis</i> Patients Attending Gondar University Hospital; Retrospective Study

Contact Info

Product

Resources

About

Mechanism of anaemia in resistant visceral leishmaniasis

Cited by 27 publications

References 8 publications

Hyponatremia in visceral leishmaniasis

Hyponatremia in visceral leishmaniasis

Hematological changes in Visceral Leishmaniasis

Haematological Abnormalities in &lt;i&gt;Visceral Leishmaniasis&lt;/i&gt; Patients Attending Gondar University Hospital; Retrospective Study

Contact Info

Product

Resources

About

Haematological Abnormalities in <i>Visceral Leishmaniasis</i> Patients Attending Gondar University Hospital; Retrospective Study