Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin

Račková, Lucia; Jančinová, Viera; Petríková, M.; Drábiková, Katarı́na; Nosáľ, R; Štefek, Milan; Kostálová, D; Prónayová, Naďa; Kovácová, Mária

doi:10.1080/14786410701371280

Cited by 81 publications

(39 citation statements)

References 17 publications

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“…The major active component of licorice root is glycyrrhizin, an oleanane-type triterpene saponin which constitutes 2-24% of total dry weight (7). Glycyrrhizin is extensively reported to have several pharmacological activities including anti-inflammatory (8), immunomodulatory (9), antiulcer (10) and anti-tumorigenic activities (11,12). Glycyrrhizin also has antiviral activity against hepatitis B virus, HIV (13,14) and severe acute respiratory syndrome (SARS)-associated coronavirus (15).…”

Section: Introductionmentioning

confidence: 99%

18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes

Munirathinam

2011

Int J Oncol

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Abstract. Glycyrrhetinic acid is an active triterpenoid metabolite of glycyrrhizin abundantly present in licorice roots. Glycyrrhetinic acid exists as α and β stereo-isomeric forms. Both stereo-isomeric forms are known to have anti-inflammatory and anticancer activity. However, the effects and anticancer mechanism of α glycyrrhetinic acid in prostate cancer cells has not yet been evaluated. Therefore, we investigated the growth inhibition, induction of apoptosis and the anticancer mechanisms of 18α-glycyrrhetinic acid (AGA), on the androgen-independent metastatic prostate cancer cell line DU-145. Our results showed that AGA inhibited proliferation and growth of these cells by inducing apoptosis as determined by Annexin V and flow cytometry analyses. Our studies also showed that HUVEC tube formation was drastically reduced when cultured in conditioned medium of AGA-treated DU-145 cells. In addition, AGA treatment prevented the invasion of DU-145 prostate cancer cells on matrigel coated transwells via down-regulation of NF-κB (p65), VEGF and MMP-9 expression. Furthermore, AGA treatment also downregulated the expression of pro-inflammatory cytokine/growth factor genes HMGB1, IL-6 and IL-8 in DU-145 cells. Interestingly, AGA simultaneously upregulated the expression of non-steroidal anti-inflammatory gene-1 (NAG-1) in DU-145 cells suggesting its anti-inflammatory activity on prostate cancer cells. Taken together, the results of this study suggest that AGA may be a promising anticancer agent that merits further investigation for the chemoprevention and treatment of prostate cancer.

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Section: Introductionmentioning

confidence: 99%

18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes

Munirathinam

2011

Int J Oncol

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“…6,7 Glycyrrhizic acid, a major triterpene glycoside isolated from Glycyrrhiza glabra L. (liquorice) and G. uralensis, is the leading natural glycoside and the chief sweet-tasting constituent of these herbs. 26,27 Given the immunological findings obtained from the glycyrrhizic acid-treated pigs based on their H1N1 and H3N2 and considering that viral load for each virus type was not analysed in this study since only M gene was amplified, it can only be suggested that this preparation allows better resistance to the natural influenza viral challenge, compared to untreated pigs. …”

Section: Resultsmentioning

confidence: 99%

Effects of glycyrrhizic acid (Viusid-Vet® powder) on the reduction of influenza virus spread and on production parameters in pigs

Ocampo-Camberos¹,

Tapia²,

Gutiérrez³

et al. 2017

Vet Méx OA

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Influenza viruses are among the most important respiratory pathogens in pigs and humans. They cause seasonal epidemics in pigs and occasional pandemics in humans. Herbal remedies have been regarded as suitable elements to aid in controlling influenza. This study was carried out to analyse the effects of the in-feed administration of glycyrrhizic acid, the best-known component of liquorice (as Viusid-Vet® powder), in pigs suffering an outbreak of influenza. Eighty crossbred Duroc-Landrace pigs, one day post-weaning (22 days old), were included in this trial. Piglets were randomly divided into the following two groups: those treated with glycyrrhizic acid and an untreated control group. Serological measurements to assess viral load and humoral responses were carried out. Blood samples from pigs were obtained every fortnight, starting on week two and ending on week 15. With these samples, haemagglutination inhibition (HI) tests were performed, using A/swine/New Jersey/11/76 (H1N1) and A/swine/Minnesota/9088-2/98 (H3N2) as reference viruses. Quantitative RT-PCR tests against the M gene of the influenza virus were also performed to assess viral shedding from nasal swab samples on weeks 1 to 8 after the beginning of the trial. Weight variables were assessed weekly for 18 weeks. In the HI tests, treated animals showed fewer positive responses compared to the control group for H1N1 and H3N2. However, a positive response to viral protection, as assessed by HI tests, was regarded as not conclusive of humoral immune stimulation. qRT-PCR tests for viral spread exhibited a lower rate of excretion for the treated group compared to the untreated one. Hence, it appears that glycyrrhizic acid stimulates, to some extent, immune responses against pig influenza as measured by viral shedding. For mean body weight, the generalized estimating equations show a higher weight gain for pigs treated with glycyrrhizic acid than the control group (P = 0.0001). These effects may assist producers in addressing the aftermath of an influenza outbreak.

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“…Its antiradical activity is reported to be responsible for its antiinflammatory action (Oh et al 2009;Rackova et al 2007;Yim et al 2007). However, the effect of AG against chemically induced depletion of DA and related biochemical parameters associated with signs and symptoms of PD and drug-induced extrapyramidal side effects or symptoms remains uncertain.…”

Section: Introductionmentioning

confidence: 95%

Effect of ammonium glycyrrhizinate on haloperidol- and reserpine- induced neurobehavioral alterations in experimental paradigms

Otari¹,

Shete²,

Bhutada³

et al. 2011

Orient Pharm Exp Med

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The present work was aimed to assess the effect of ammonium glycyrrhizinate, AG (50, 100, and 150 mg/kg, i.p.) on haloperidol induced catalepsy in mice; reserpine induced orofacial dyskinesia in rats; and reserpine antagonism in mice. Additionally the effect of AG on lipid peroxidation (LP) in cataleptic mice brain and monoamine oxidase-B (MAO-B) levels in normal mice brain was assessed. Administration of AG 100 and 150 mg/kg showed significant reduction in the duration of cataleptic behavior at 60 to 180 min and dose dependent decrease in LP induced by haloperidol. AG showed significant decrease in frequency of vacuous chewing movements at 150 mg/kg and frequency of tongue protrusion at 100 and 150 mg/kg in reserpine induced orofacial dyskinesia test. AG showed significant increase in frequency of horizontal movement and rearing behavior at 150 mg/kg and increase in grooming behavior at 100 and 150 mg/kg in reserpine antagonism test. AG showed dose dependent inhibition of MAO-B in the normal mice brain. These results suggested that AG prevented the haloperidol-and reserpine-induced neurobehavioral alterations possibly by acting as free radical scavenger or inhibiting MAO-B thereby increasing dopaminergic transmition consequently decreasing dopamine metabolites and ultimately preventing the generation of free radicals.

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Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin

Cited by 81 publications

References 17 publications

18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes

18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes

Effects of glycyrrhizic acid (Viusid-Vet® powder) on the reduction of influenza virus spread and on production parameters in pigs

Effect of ammonium glycyrrhizinate on haloperidol- and reserpine- induced neurobehavioral alterations in experimental paradigms

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