Mechanism of Antitumour Action of 1-Amino-Cyclopentane Carboxylic Acid

Berlinguet, Louis; Bégin, Nicole; Sarkar, Nirmal Kumar

doi:10.1038/1941082a0

Cited by 30 publications

(9 citation statements)

References 10 publications

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“…In this latter case, ACPC was thought to compete for the valine-leucine transport system and the resulting reduced uptake of the protein amino acids into the celIs was considered a sufficient explanation of their limited incorporation into protein. However, ACPC also inhibited the incorporation of 14C-valine into ribosome-bound protein in cell-free preparations from rat liver, although no incorporation of 14C-ACPC into protein was demonstrated (199). These in vitro observations indicate that ACPC can directly influence processes responsible for the incorporation of amino acids into protein, and other experiments suggested that the formation of the aminoacylsRNA complex was inhibited.…”

Section: Miscellaneous Analogs and Toxic Amino Acidsmentioning

confidence: 88%

“…For instance, the rate of incorporation of 14C-valine into the liver proteins of rats, treated earlier with ACPC, was reduced when compared with normal animals (199). Similarly, the introduction of both 14C-leucine and 14C-valine into protein of ascites tumor cells was restricted in the presence of ACPC (200).…”

Section: Miscellaneous Analogs and Toxic Amino Acidsmentioning

confidence: 95%

See 1 more Smart Citation

Toxic Amino Acids: Their Action as Antimetabolites

Fowden¹,

Lewis²,

Tristram³

1967

Advances in Enzymology - And Related Areas of Molecular Biology

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Section: Miscellaneous Analogs and Toxic Amino Acidsmentioning

confidence: 88%

Section: Miscellaneous Analogs and Toxic Amino Acidsmentioning

confidence: 95%

Toxic Amino Acids: Their Action as Antimetabolites

Fowden¹,

Lewis²,

Tristram³

1967

Advances in Enzymology - And Related Areas of Molecular Biology

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“…[151,152]. ACPC, also known as cycloleucine, has also been evaluated as a chemotherapeutic agent [153,154]. A comparative preclinical study of 1-amino-cyclopropane-1-carboxylic acid (ACPRC), ACBC, ACPC and 1-amino-cyclohexne-1-carboxylic acid (ACHC) labeled with carbon-14 was performed in rats transplanted with Morris 51236 hepatomas [155].…”

Section: Alicyclic Amino Acidsmentioning

confidence: 99%

Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

McConathy

Goodman

2008

Cancer Metastasis Rev

109

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Amino acids are required nutrients for proliferating tumor cells, and amino acid transport is upregulated in many tumor types. Studies of radiolabeled amino acids in animals and humans demonstrate that amino acid based tracers have advantageous characteristics relative to 2-[(18)F]fluoro-2-deoxyglucose in certain tumors, particularly brain gliomas. Non-natural amino acids for tumor imaging generally have greater metabolic stability and can be labeled with longer-lived radionuclides for positron emission tomography and single photon emission computed tomography such as fluorine-18 and iodine-123. Amino acids enter cells via amino acid transport with varying selectivity based on their chemical structure. This review focuses on the rationale, biological basis, current status and future prospects of radiolabeled non-natural amino acids for tumor imaging and discusses various classes of these compounds including aromatic, alicyclic and alpha,alpha-dialkyl amino acids.

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“…for several days. Berlinguet et aZ (4) obtained evidence indicating that ACPC inhibited protein synthesis in vivo and in vitro by preventing the attachment of valine to transfer RNA. In experiments with rats fed diets containing ACPC, Ross et al (3) reported a decreased growth rate and suggested that the compound might function as an amino acid antagonist.…”

mentioning

confidence: 99%

“…In Experiment 111, the rats received 5 g of diet 4 times per day and the experiment was continued for 1 week. In Experiment 111, the rats received 5 g of diet 4 times per day and the experiment was continued for 1 week.…”

mentioning

confidence: 99%