MECHANISM OF ANTIVIRAL ACTION AND EVALUATION OF THE EFFICACY OF THE NEW PREPARATION FORTEPREN&lt;sup&gt;®&lt;/sup&gt; IN THE COMPLEX THERAPY OF CHRONIC RECURRENT HERPESVIRUS INFECTION OF GENITAL LOCALIZATION

Sedov, Alexander M.; Наровлянский, А. Н.; Пронин, А В; Санин, А. В.; Зубашев, И. К.; Izmest'eva, A V; Иванова, А М; Парфенова, Т. М.; Shulzhenko, A E; Зуйкова, И Н; Shubelko, Rosaliya V.; Khaldin, A. A.; Исаева, Д. Р.; Селькова, Е. П.; Григорьева, Е А

doi:10.36233/0372-9311-2018-5-81-87

Cited by 2 publications

(6 citation statements)

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“…Alphaviral infection of mice caused by the Western equine encephalitis virus (California strain) at a dose of 10 LD 50 /0.1 mL showed that the introduction of FP subcutaneously (s/c) or i/a in doses of 10-100 μg/mouse according to treatment-and-prophylactic or treatment schemes increased the protection of mice by 40-50% and extended the ALE (average life expectancy) by 4-5 days (Narovlyansky et al, 2018).…”

Section: Antiviral Efficacy Ofmentioning

confidence: 99%

“…In the group of hamsters who received FP, the death of animals came only on the 18th day after infection, which corresponds to the normal course of acute infection. Daily injections of FP to animals in an extremely serious condition made it possible to keep them alive throughout the experiment (Narovlyansky et al, 2018).…”

Section: Antiviral Efficacy Ofmentioning

confidence: 99%

“…The lipophilic prenyl group facilitates the consolidation of proteins in cell membranes, mediating protein-white interactions and signal transmission. This explains the extraordinary variety of physiological properties of polyprenols: they have immunomodulating (Pronin et al, 2002), adjuvant (Pronin et al, 2011), antioxidant (Sanin et al, 2017a), anti-inflammatory (Ganshina et al, 2011), and other important properties (Narovlyansky et al, 2018), which makes them attractive objects for the development of therapeutic remedies (Narovlyansky et al, 2007). The purpose of this article is to analyze the wealth of information about the antiviral activity of these unique compounds.…”

Section: Introductionmentioning

confidence: 99%

“…FP at a dose of 200 μg was introduced intramuscularly (i/m) or p/o daily for two weeks. As a result, the increase in the survival of mice was 40-60% (Narovlyansky et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression

et al. 2022

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This review is focused on polyprenyl phosphatis (PPFs) (phosphorilated polyprenols), a unique class of natural compounds with a wide spectrum of biological activity. The main emphasis is put on their antiviral properties that were studied in numerous in vitro and in vivo experiments. The results formed the basis for the development of new drugs containing PPFs as the active substance. These drugs, due to their high efficiency and harmlessness, are widely used in veterinary practice in the treatment of viral diseases of both small domestic and agricultural animals. Also, the world’s first PPF-based drug is registered in Russia, and it can be used as part of a comprehensive therapy of chronic recurrent genital infection caused by the herpes simplex virus.

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Section: Antiviral Efficacy Ofmentioning

confidence: 99%

Section: Antiviral Efficacy Ofmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…FP at a dose of 200 μg was introduced intramuscularly (i/m) or p/o daily for two weeks. As a result, the increase in the survival of mice was 40-60% (Narovlyansky et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression

et al. 2022

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“…The drug showed an acceptable safety profile and a good level of tolerance. The study was carried out on 62 patients with genital herpes who underwent the standard protocol of therapy with acyclovir following which they were given either three PPP injections, or three injection of placebo, after which they were observed for 90 days (Narovlyansky et al 2015b , 2015c ; Ershov et al 2017 ; Pronin et al 2016 ; Sedov et al 2018 ).…”

Section: Introductionmentioning

confidence: 99%

New Approaches to the Prevention and Treatment of Viral Diseases

Пронин

Narovlyansky

Санин

2021

Arch. Immunol. Ther. Exp.

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The review discusses a new approach to the prevention and treatment of viral infections based on the use of pine needles polyprenyl phosphate (PPP) and associated with the infringement of prenylation process—the attachment of farnesol or geranyl geraniol to the viral protein. Currently, prenylation has been detected in type 1 adenovirus, hepatitis C virus, several herpes viruses, influenza virus, HIV. However, this list is far from complete, given that prenylated proteins play an extremely important role in the activity of the virus. We assume that the interferon produced in response to PPP may suppress expression of the SREBP2 transcription factor. As a result, the mevalonic acid pathway is violated and, as a result, the formation of early polyprenols precursors (geraniol, geranyl geraniol, farnesol), which are necessary for the prenylation of viral proteins, is blocked and the formation of mature, virulent virus particles is broken. As a consequence, the maturation of viral particles is inhibited, and defective particles are formed. Polyprenol was extracted from greenery (pine, fir and spruce needles, mulberry leaves, etc.), purified by chromatography, phosphorylated and identified by HPLC and NMR. Obtained PPP was used as antiviral in some experimental models in vitro and in vivo. During numerous studies, it was found that PPP manifested versatile antiviral effects, both in vitro and in vivo. The maximum effect was observed with viruses in which the presence of prenylated proteins was established, namely influenza A virus, HIV-1, tick-borne encephalitis virus, hepatitis A and C viruses, herpes simplex viruses type 1 and 2, some coronavirus. The available data obtained both in the experimental conditions and during clinical trials allow us to regard PPPs as safe and effective medicine for prevention and treatment of viral diseases.

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MECHANISM OF ANTIVIRAL ACTION AND EVALUATION OF THE EFFICACY OF THE NEW PREPARATION FORTEPREN<sup>®</sup> IN THE COMPLEX THERAPY OF CHRONIC RECURRENT HERPESVIRUS INFECTION OF GENITAL LOCALIZATION

Cited by 2 publications

References 1 publication

Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression

Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression

New Approaches to the Prevention and Treatment of Viral Diseases

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