Mechanism of augmented left atrial pump function in myocardial infarction and essential hypertension evaluated by left atrial pressure-dimension relation

Matsuzaki, Masunori; Tamitani, M; Toma, Yoichi; Ogawa, Hiroshi; Katayama, Kazuhiro; Matsuda, Yasuo; Kusukawa, Reizo

doi:10.1016/0002-9149(91)90876-m

Cited by 77 publications

(47 citation statements)

References 20 publications

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“…These results were correlated with the fall in LA pressure (Basnight et al 1991). In MS LA function may be disrupted due to increased LA afterload (Matsuda et al 1983;Matsuzaki et al 1991). It has been shown that LA afterload and the mean LA pressure decreases following PMV (Stefanadis ) 1.67 ± 0.16 Systolic blood pressure (mmHg) 130 ± 9 Diastolic blood pressure (mmHg) 77 ± 5 Heart rate (beat/min) 74 ± 9 et al 1998).…”

Section: Discussionmentioning

confidence: 89%

“…Because it is well known that normal LA has a reservoir, conduit and pump function (Matsuda et al 1983;Matsuzaki et al 1991). On the other hand, percutaneous balloon mitral valvuloplasty (PMV) is a therapeutic option in selected patients with MS.…”

confidence: 99%

“…The functions of LA are (a) passive transport or conduit for pulmonary venous blood to the left venticle (LV) during ventricular diastole, (b) reservoir for storage of blood during ventricular systole and (c) active transport or pump function, that provides energy for filling LV beyond that provided by ventricular systole (Matsuda et al 1983;Matsuzaki et al 1991). Left atrial maximal volume (LAVmax) was measured just at the time of the opening of the mitral valve, left atrial minimal volume (LAVmin) was measured at the time of the closure of the mitral valve and the left atrial presystolic volume (LAVp) was measured synchronously with the start of the P wave on electrocardiography.…”

Section: Left Atrial Mechanical Functionmentioning

confidence: 99%

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Early Effects of Percutaneous Mitral Valvuloplasty on Left Atrial Mechanical Functions

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et al. 2006

Tohoku J. Exp. Med.

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It has been suggested that successful percutaneous balloon mitral valvuloplasty (PMV) decreases the intensity of spontaneous left atrial contrast, reduces the size of the left atrium, and improves left atrial function in patient with mitral stenosis. However, left atrial mechanical functions immediately after PMV have not been extensively evaluated yet. The aim of this study was to evaluate the effects of PMV on left atrial mechanical functions. Twenty patients with critical mitral stenosis who have normal sinus rhythm (male/female: 4 to 16; mean age: 33 ± 8 years) were included in the study. Left atrial mechanical functions were evaluated before and after PMV, including left atrial passive emptying volume, LA passive emptying fraction, conduit volume, left ventricular stroke volume, LA active emptying volume, LA active emptying fraction, LA total emptying volume and LA total emptying fraction. PMV resulted in a significant increase in the mitral valve area ( p < 0.001) and a substantial reduction in the mean transmitral pressure gradient ( p < 0.001) as well as LA diameter ( p < 0.002). LA maximal volume, minimal volume and atrial presystolic volumes were significantly decreased after PMV ( p: 0.001; p: 0.002; p: 0.001, respectively). The conduit volume was increased and LA total emptying volume was decreased after PMV ( p: 0.014; p: 0.035). The other left atrial volumes were not altered after PMV. The early increase in conduit volume and the decrease in left atrial presystolic volume indicate that PMV has favorable effects on atrial reservoir and conduit functions. PMV therefore improves atrial mechanic functions. left atrial mechanical functions; percutaneous mitral valvuloplasty; mitral stenosis

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Section: Discussionmentioning

confidence: 89%

confidence: 99%

Section: Left Atrial Mechanical Functionmentioning

confidence: 99%

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Early Effects of Percutaneous Mitral Valvuloplasty on Left Atrial Mechanical Functions

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et al. 2006

Tohoku J. Exp. Med.

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“…[20][21][22] Theoretically, AF causes a functional loss of the left atrium, especially the loss of contractile function. An observation from De Ferrari, et al 23) , namely, that AF leads to a more severe disease rating in the New York Heart Association classification, indicates that AF aggravates heart failure.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Cardiopulmonary Exercise Testing in Cardiac Patients With Atrial Fibrillation

et al. 2012

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SummaryParameters obtained from cardiopulmonary exercise testing (CPX) are recognized for their high prognostic value in predicting future cardiac events in cardiac patients. Our group compared the prognostic value of CPX parameters between patients with sinus rhythm (SR) and patients with atrial fibrillation (AF).Peak O2 uptake (VO2), the ratio of the increase in VO2 to the increase in work rate ( ∆VO2/ ∆WR), and the slope of the increase in ventilation to the increase in CO2 output (VE-VCO2 slope) were obtained from CPX in 72 AF patients and 478 SR patients. The prognostic values of these indices were compared between the two groups.Six cardiac deaths and 25 cardiac events were observed in the AF group and 9 cardiac deaths and 96 cardiac events were observed in the SR group, over a prospective follow-up period of 1,192 days. The percentages of cardiac deaths and cardiac events were higher in the AF group than in the SR group. In a multivariate Cox proportional hazards analysis, peak VO2 was identified as a sole significant predictor of cardiac death and cardiac events in SR patients and VE-VCO2 slope was identified as a sole significant predictor of cardiac death and cardiac events in AF patients.Our results suggest that the VE-VCO2 slope is strongly predictive of future cardiac events in patients with AF and that peak VO2 is strongly predictive of future cardiac events in SR patients. (Int Heart J 2012; 53: 102-107)

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“…[15][16][17][18][19][20] LA dilatation is usually recognized on the M-mode and two-dimensional echocardiogram; ultrafast computerized tomography, magnetic resonance imaging and radionuclide methods have also been introduced to identify changes in LA volumes and functions. [21][22][23] In routine clinical practice, the most commonly used approach has been the manual tracing method, which includes tracing the LA inner surface on a two-dimensional echocardiographic window providing the best image of the LA.…”

Section: Discussionmentioning

confidence: 99%

Left Atrial Maximum Volume Is a Recurrence Predictor in Lone Atrial Fibrillation. An Acoustic Quantification Study.

et al. 2002

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SUMMARYPredictors of recurrence in lone atrial fibrillation have not been clearly identified. Acoustic quantification (AQ) is a promising method in the assessment of left atrial (LA) volumes. The purpose of the present study was to investigate the potential of LA volumes obtained by standard manual tracing and AQ methods in predicting AF-recurrence after restoring the sinus rhythm in patients with lone AF, and to test the agreement between the two approaches. Standard echocardiography combined with AQ was performed in 28 patients with lone AF one hour after the sinus rhythm was regained, and in 10 controls. LA volumes were determined by conventional manual tracing and AQ methods. AQ waveforms of LA were obtained by drawing a region of interest around the LA border. The agreement of the two methods was tested by Bland-Altman analysis. Patients were followed up for 6 months for the occurrence of AF recurrence. A good correlation was observed between AQ and manual tracing methods in determining both minimal (r=0.59) and maximal (r=0.88) LA volumes. Patients with AF recurrence had a significantly larger maximum LA volume as assessed with both methods (P<0.05 for both). M-mode derived LA dimension and isovolumic relaxation time were additional predictors of recurrence in patients with lone AF. In lone AF, patients prone to recurrence could be predicted by determining LA maximum volume assessed either by AQ or manual tracing methods. AQ provides on-line, accurate estimation of LA volumes. (Jpn Heart J 2002; 43: 241-248)

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Mechanism of augmented left atrial pump function in myocardial infarction and essential hypertension evaluated by left atrial pressure-dimension relation

Cited by 77 publications

References 20 publications

Early Effects of Percutaneous Mitral Valvuloplasty on Left Atrial Mechanical Functions

Early Effects of Percutaneous Mitral Valvuloplasty on Left Atrial Mechanical Functions

Prognostic Value of Cardiopulmonary Exercise Testing in Cardiac Patients With Atrial Fibrillation

Left Atrial Maximum Volume Is a Recurrence Predictor in Lone Atrial Fibrillation. An Acoustic Quantification Study.

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