1971
DOI: 10.1016/0006-2944(71)90069-x
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Mechanism of bilirubin toxicity on tissue culture cells: Factors that affect toxicity, reversibility by albumin, and comparison with other respiratory poisons and surfactants

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Cited by 80 publications
(28 citation statements)
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“…13,17 In this regard, it is notable that our studies demonstrate substantial cytotoxic effects of bilirubin on HCT15 cells at molar ratios of bilirubin:BSA that are well below unity. These findings are in line with data reported by Chuniaud et al, 24 who showed that halfmaximal lysis of rat fibroblasts and astrocytes at 48 hr occurred at bilirubin:human serum albumin ratios of 0.75 and 0.85, respectively.…”
Section: Effect Of Bilirubin On the Permeability Of Isolated Mitochonmentioning
confidence: 66%
See 1 more Smart Citation
“…13,17 In this regard, it is notable that our studies demonstrate substantial cytotoxic effects of bilirubin on HCT15 cells at molar ratios of bilirubin:BSA that are well below unity. These findings are in line with data reported by Chuniaud et al, 24 who showed that halfmaximal lysis of rat fibroblasts and astrocytes at 48 hr occurred at bilirubin:human serum albumin ratios of 0.75 and 0.85, respectively.…”
Section: Effect Of Bilirubin On the Permeability Of Isolated Mitochonmentioning
confidence: 66%
“…While there have been a handful of in vitro studies demonstrating cytotoxic effects of bilirubin on neuroblastoma, 13,14 hepatoma, 15,16 fibrosarcoma 17 and Ehrlich ascites tumor cells, 18 there is scant information regarding the mechanism underlying these effects. Bilirubin inhibits osteoblast proliferation 19 and stimulates apoptosis in rat brain neurons, 20 -23 astrocytes, 24 fibroblasts 24 and bovine brain endothelial cells.…”
mentioning
confidence: 99%
“…Finally, it has been shown that this protein appears in the plasma and CSF of jaundiced rats (33). The effects of bilirubin on the brain may include increased membrane permeability in the neurons (34)(35)(36)(37). Increased permeability to small molecules such as ions, resulting in changes in the membrane potential, is likely to precede leakage of larger molecules such as proteins from the neurons.…”
mentioning
confidence: 99%
“…It is well established that bilirubin is toxic to neural cells; however, the mechanism and pathogenesis of its toxicity remains unclear (6,8). As preventive measures are taken very early during the course of neonatal hyperbilirubinemia, the number of cases with irreversible bilirubin encephalopathy are now of rare occurrence.…”
Section: Discussionmentioning
confidence: 99%
“…Bilirubin is added to the culture medium to non. Cowger (8) below were carried out in triplicate analyses.…”
Section: Which Is Progressive and Irreversible (Pediatr Res 25369-37mentioning
confidence: 99%