Mechanism of Biofilm Formation in Gram-Negative Bacteria

Vasconcelos, Ulrich; Das, Palashpriya; Dias, D. H. N.; Bonifácio, Tarcísio Tárcio Corrêa; Arruda, Ray Ravilly Alves; Oliveira, Bianca Teixeira Morais de; Cavalcanti, Thiago Gonçalves

doi:10.21775/9781912530328.02

Cited by 2 publications

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“…Biofilms are sessile microbial communities in which cells live in a complex closed association network, surrounded by an adhesive polymeric matrix (EPS) [ 60 ]. The carbon source and nutrient levels are the main factors that govern the establishment of a biofilm [ 61 ]. The reduction of nutrients to produce EPS obliges the bacteria to maintain a planktonic lifestyle [ 62 ].…”

Section: Pseudomonas Aeruginosa : the Exclusivementioning

confidence: 99%

Colour Me Blue: The History and the Biotechnological Potential of Pyocyanin

Gonçalves

Vasconcelos

2021

Molecules

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Pyocyanin was the first natural phenazine described. The molecule is synthesized by about 95% of the strains of Pseudomonas aeruginosa. From discovery up to now, pyocyanin has been characterised by a very rich and avant-garde history, which includes its use in antimicrobial therapy, even before the discovery of penicillin opened the era of antibiotic therapy, as well as its use in electric current generation. Exhibiting an exuberant blue colour and being easy to obtain, this pigment is the subject of the present review, aiming to narrate its history as well as to unveil its mechanisms and suggest new horizons for applications in different areas of engineering, biology and biotechnology.

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Section: Pseudomonas Aeruginosa : the Exclusivementioning

confidence: 99%

Colour Me Blue: The History and the Biotechnological Potential of Pyocyanin

Gonçalves

Vasconcelos

2021

Molecules

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“…Bacteria can grow as free-living and sessile population (1). The preferred bacterial lifestyle choice is complex, strain dependent, and dictated by multiple environmental factors (2). Biofilm lifestyle provides multiple advantages for bacteria and has a relevant virulence mechanism in terms of medically important pathogens (3).…”

Section: Introductionmentioning

confidence: 99%

Preliminary insights into the action of non-antibiotic pharmaceuticals in the colonization of Pseudomonas aeruginosa TGC04

Abdelhadi

Bandeira

Pragana³

et al. 2023

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Molecules with antimicrobial properties, such as those found in non-antibiotic pharmaceuticals, may pressure bacteria to adapt to the environment. In this work, five of the most sold non-antibiotic pharmaceuticals in Brazil and in Egypt in 2020 (losartan 50 mg, acetylsalicylic acid 100 mg, diclofenac 50 mg, paracetamol 750 mg and metformin 500 mg and dipyrone 100 mg/mL), were tested against the wild strain Pseudomonas aeruginosa TGC04, previously isolated by our group and which has been characterized over the years. We evaluated inhibition of biofilm adhesion over 48 h using the crystal violet test. Exposure of P. aeruginosa TGC04 to the compounds promoted a similar moderate reduction in adherence for all the pharmaceuticals tested, amounting to about 60%. This indicated that the cells were also moderately adherent. However, although all non-antibiotic pharmaceuticals did not produce a biocidal effect on the wild strain, intense antibiofilm activity was observed, except for paracetamol.

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Mechanism of Biofilm Formation in Gram-Negative Bacteria

Cited by 2 publications

References 0 publications

Colour Me Blue: The History and the Biotechnological Potential of Pyocyanin

Colour Me Blue: The History and the Biotechnological Potential of Pyocyanin

Preliminary insights into the action of non-antibiotic pharmaceuticals in the colonization of Pseudomonas aeruginosa TGC04

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