Mechanism of blood coagulation in normal and pathologic conditions

Stefanini, Mario

doi:10.1016/0002-9343(53)90359-3

Cited by 49 publications

(2 citation statements)

References 59 publications

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“…Since then this factor has been given a variety of different names: cothromboplastin (Mann and Hurn, 195 I), serum prothrombin conversion accelerator (S.P.C.A.) (De Vries, Alexander and Goldstein, 1949)~ convertin (Owren, 1951), stable component (Stefanini, 1953) and Factor VII (Koller, Loeliger and Duckert, 1951). The latter term will be used throughout this paper to refer both to the factor itself, and to its possible plasma precursor.…”

mentioning

confidence: 99%

The Function of Factor VII

Ackroyd

1956

Br J Haematol

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mentioning

confidence: 99%

The Function of Factor VII

Ackroyd

1956

Br J Haematol

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“…Stefanini (56) in his recent review on blood coagulation summarized the various theories on the action of platelets in accelerating the conversion of prothrombin to thrombin. In these experiments in which no prothrombin is present there is no possibility for such an action to occur.…”

Section: Discussionmentioning

confidence: 99%

Effects of Thrombin and Platelet Concentrations and of Clot Retraction on Fibrin Strand Widths 12

Greene¹,

McConaughy²

1955

J. Clin. Invest.

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Stubel in 1914 (1) first noted with an ultramicroscope that the fibrin strands produced from hemophilic blood are thicker than from normal blood. He attributed the thicker strands to the slower rate of clotting in hemophilic blood. Later in the same year Howell (2) performing similar kinds of experiments reported an experiment in which cat's plasma was clotted with thrombin: "A large amount of thrombin caused very rapid clotting with the production of small but distinct needles, while with a small amount of thrombin the clotting was slow and the needles were relatively large." In 1947, Ferry and Morrison (3) reported a similar microscopic observation in which decreasing thrombin concentration produced larger fibrin strands. They observed this at pH 6.0 since at pH 7.0 the strands were too fine to be seen. Morrison and Scudder (4) working at pH 6.4 believed there was no change in the thickness of the fibrin strands with varying thrombin concentrations. This was based on electron microscope photographs. A light scattering method for the determination of the average fibrin strand width has been reported previously from this laboratory (5). With this technique it is now possible to examine the effect of thrombin concentration on fibrin strand width in more detail.Although numerous papers have been written on the relation of platelets to clot retraction 8 (7,

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Survey of the 1953 Hematology Literature

Wright¹

1954

Arch Intern Med

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Mechanism of blood coagulation in normal and pathologic conditions

Cited by 49 publications

References 59 publications

The Function of Factor VII

The Function of Factor VII

Effects of Thrombin and Platelet Concentrations and of Clot Retraction on Fibrin Strand Widths 12

Survey of the 1953 Hematology Literature

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