2015
DOI: 10.1096/fasebj.29.1_supplement.1011.4
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Mechanism of Ceruloplasmin‐Copper Uptake by, and Overexpression in, Mammalian Cells

Abstract: Ceruloplasmin (Cp) is an abundant multifunctional copper‐binding protein in the blood plasma best known for its ferroxidase activity. Using purified 64Cu‐labeled Cp, we have now established that it also delivers copper directly to cultured cells. Here, we further examined whether this process occurs at the cell surface, involving a reductase, and attempted to identify a new copper transporter and overexpress human Cp. Uptake of copper from 64Cu‐Cp (purified from mouse plasma) by mouse embryonic fibroblasts tha… Show more

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