Mechanism of Chinese Medicinal-Medicated Leaven for Preventing and Treating Gastrointestinal Tract Diseases

Fu, Xin; Wang, Qiuhong; Kuang, Hai‐Xue; Jiang, Peng

doi:10.1159/000493424

Cited by 10 publications

(6 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Colors of target nodes indicate KEGG pathways that the targets were associated with. Edges between herb nodes and compound nodes indicate that the herbs contain the compounds, and edges between compound nodes and target nodes indicate that the compounds were predicted to target the genes in digestive function and its secondary metabolites, powerful antioxidant and anti-inflammatory activities [51]. ML assists "Kun" as "Choa" in P05 by ameliorating the side-effects of "Kun. "…”

Section: Discussionmentioning

confidence: 99%

“…Medicated leaven (ML) is a fermented mixture of wheat flour, Artemisia annua, Xanthium sibiricum, Polygonum hydropiper, Vigna angularis, and bitter Prunus armeniaca Kernel. ML, Shen qu, has been used to treat gastrointestinal (GI) diseases for thousands of years, such as reducing food stagnation, strengthening the stomach (stomach cold with food stagnation or accumulation, with epigastric and abdominal fullness or distention), lack of appetite, borborygmus, and diarrhea [51]. The primary components and related specific bioactive constituents of ML are described in the following sections.…”

Section: Medicated Leaven As a "Sa-ambassador"mentioning

confidence: 99%

See 1 more Smart Citation

The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis

et al. 2021

View full text Add to dashboard Cite

The prevalence of gastroesophageal reflux disease (GERD) is rapidly increasing due to the adoption of a Westernized lifestyle; at the same time, safe and efficient treatment is required due to the side effects and refractoriness of proton pump inhibitors (PPIs). The frequently used multi-compound treatment for GERD in the current traditional Korean medicine (TKM) clinical field comprises Crassostrea gigas Thunberg shell (CGTS), Bambusae Caulis in Taeniam (BCT), Ponciri Fructus Immaturus (PFI), Scutellaria baicalensis Georgi (SBG), medicated leaven (ML) and Glycyrrhizae Radix et Rhizoma (GRR). The current review was based on “Kun-Shin-Choa-Sa” theory and network analysis was conducted to explore the potential pharmacological activities, including efficacy and mechanisms of action of multi-compound treatment against GERD. Hypergeometric test results showed that the targets of multi-compound treatment are significantly associated with GERD gene sets, consistent with the literature review findings. In particular, the enrichment analysis indicated that the SBG targets are related to the IL-17 signaling pathway, bile secretion, small-cell lung cancer, and non-small cell lung cancer, corroborating the literature review, particularly concerning anti-inflammatory effect. In the literature review, CGTS and BCT, classified as “Kun,” play a role in anti-acid, anti-inflammatory, and anti-oxidative effects. The complementary “Shin” herbs, PFI and SBG, showed functions related to improving the prolonged gastric emptying rate, peristalsis, and a gastric cytoprotective effect. With the role of “Choa,” ML was suggested to inhibit H. pylori growth and diminish gastric acid secretion, consistent with the gastric acid secretion pathway in the enrichment analysis. However, the enrichment analysis did not show any significantly related pathways for CGTS and PFI, which may reflect the lack of information in the KEGG database in terms of the link between GERD, its mechanisms, and the abundance of minerals in CGTS. Despite the pharmacological potential of multi-compound treatment, this study should be corroborated by well-designed future experimental studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Medicated Leaven As a "Sa-ambassador"mentioning

confidence: 99%

The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The role of the agricultural and related sectors is to mitigate the deleterious effects of ecological and environmental disorders that may be aquatic or terrestrial, by modifying food production with a bias for food crops that have counteractive effects on the adverse effects of pollution such as fruits and vegetables, with special attention to areas of environmental pollution and ecological shifts. This is probably why the Chinese with high incidence of cancer of the oesophagus and other parts of the gastrointestinal tract are currently among the greatest producers and consumers of fruit and vegetables (He et al, 2016;Fu et al, 2020;Wang et al, 2022). This may also be true of the Mediterranean diet in Europe with its health beneficial impact.…”

Section: Suggested Roles Of the Agricultural Health And Other Sectors...mentioning

confidence: 99%

Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health

et al. 2022

View full text Add to dashboard Cite

There is current great international concern about the contribution of environmental pollution to the global burden of disease particularly in the developing, low- and medium-income countries. Industrial activities, urbanization, developmental projects as well as various increased anthropogenic activities involving the improper generation, management and disposal of pollutants have rendered today’s environment highly polluted with various pollutants. These pollutants include toxic metals (lead, cadmium, mercury, arsenic), polycyclic aromatic hydrocarbons, polychlorinated biphenyls, pesticides and diesel exhaust particles most of which appear to be ubiquitous as well as have long-term environmental persistence with a wide range of toxicities such as oxidative stress among others. Oxidative stress, which may arise from increased production of damaging free radicals emanating from increased pollutant burden and depressed bioavailability of antioxidant defenses causes altered biochemical and physiological mechanisms and has been implicated in all known human pathologies most of which are chronic. Oxidative stress also affects both flora and fauna and plants are very important components of the terrestrial environment and significant contributors of nutrients for both man and animals. It is also remarkable that the aquatic environment in which sea animals and creatures are resident is also highly polluted, leading to aquatic stress that may affect the survival of the aquatic animals, sharing in the oxidative stress. These altered terrestrial and aquatic environments have an overarching effect on human health. Antioxidants neutralize the damaging free radicals thus, they play important protective roles in the onset, progression and severity of the unmitigated generation of pollutants that ultimately manifest as oxidative stress. Consequently, human health as well as that of aquatic and terrestrial organisms may be protected from environmental pollution by mitigating oxidative stress and employing the principles of nutritional medicine, essentially based on antioxidants derived mainly from plants, which serve as the panacea of the vicious state of environmental pollutants consequently, the health of the population. Understanding the total picture of oxidative stress and integrating the terrestrial and aquatic effects of environmental pollutants are central to sustainable health of the population and appear to require multi-sectoral collaborations from diverse disciplinary perspectives; basically the environmental, agricultural and health sectors.

show abstract

“…Hawthorn has also been widely applied to manage hyperlipidaemia and cardiovascular diseases [13]. Medicated leaves improve human immunity through antioxidant and anti-inflammatory activities that lead to regulation of the gut microflora balance [16].…”

Section: Introductionmentioning

confidence: 99%

Overall Structural Alteration of Gut Microbiota and Relationships with Risk Factors in Patients with Metabolic Syndrome Treated with Inulin Alone and with Other Agents: An Open-Label Pilot Study

Tian

Hong

Zhao

et al. 2022

Mediators of Inflammation

View full text Add to dashboard Cite

Objective. The relative contribution of some products with prebiotic effects, such as inulin, together with medications specific to the human gut microbiome has not been comprehensively studied. The present study determined the potential for manipulating populations in the gut microbiome using inulin alone and combined with other agents in individuals with metabolic syndrome (MetS). The study also assessed whether there is relationship variability in multiple clinical parameters in response to intervention with the changes in the gut milieu. Participants/Methods. This single-centre, single-blinded, randomised community-based pilot trial randomly assigned 60 patients (mean age, 46.3 y and male, 43%) with MetS to receive either inulin, inulin+traditional Chinese medicine (TCM), or inulin+metformin for 6 months. Lipid profiles, blood glucose, and uric acid (UA) levels were analysed in venous blood samples collected after overnight fast of 8 h at baseline and at the end of the follow-up period. Microbiota from stool samples were taxonomically analysed using 16S RNA amplicon sequencing, and an integrative analysis was conducted on microbiome and responsiveness data at 6 months. Results. The results of 16S rRNA sequencing showed that inulin resulted in a higher proportion of Bacteroides at the endpoint compared with inulin+TCM and inulin+metformin ( p = 0.024 ). More Romboutsia ( p = 0.043 ), Streptococcus ( p < 0.001 ), and Holdemanella ( p = 0.011 ) were found in inulin+TCM and inulin+metformin samples. We further identified gut microbiota relationships with lipids, UA, and glucose that impact the development of MetS. Conclusion. Among the groups, inulin alone or combined with metformin or TCM altered specific gut microbiota taxa but not the general diversity. Accordingly, we analysed metabolites associated with microbiota that might provide more information about intrinsic differences. Consequently, a reliable method could be developed for treating metabolic syndrome in the future.

show abstract

Mechanism of Chinese Medicinal-Medicated Leaven for Preventing and Treating Gastrointestinal Tract Diseases

Cited by 10 publications

References 40 publications

The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis

The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis

Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health

Overall Structural Alteration of Gut Microbiota and Relationships with Risk Factors in Patients with Metabolic Syndrome Treated with Inulin Alone and with Other Agents: An Open-Label Pilot Study

Contact Info

Product

Resources

About