Mechanism of copper nanoparticle toxicity in rainbow trout olfactory mucosa

Razmara, Parastoo; Imbery, Jacob J.; Koide, Emily M.; Helbing, Caren C.; Wiseman, Steve; Gauthier, P.; Bray, D. F.; Needham, Maurice; Haight, Travis; Zovoilis, Athanasios; Pyle, Greg G.

doi:10.1016/j.envpol.2021.117141

Cited by 23 publications

(23 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The EOG signal captured was then amplified, filtered, digitized, and quantified with a physiological signal acquisition and process system (1000×, 2–500 Hz, BL-420N, Chengdu Techman Software Co. Ltd., China). Following the methods previously reported, , the relative EOG responses to olfactory stimuli were subsequently calculated by dividing the EOG values obtained by that of the control to minimize potential impacts of individual variations.…”

Section: Methodsmentioning

confidence: 99%

“…auratus), a close relative of economically important carps and a model species that has been widely used in various toxicological studies . In addition to the traditional behavioral assays, the electroolfactogram (EOG) responses, a sensitive olfactory electrophysiological indicator, to olfactory stimuli were also monitored in this study. − In order to find out how the initiation of the olfactory signal was disrupted by FLX, the health status, the activities of ion pumps, and the expression of genes related to the generation of the olfactory signal were evaluated in OE. Moreover, the effects of FLX on the transmission (indicated by the expression levels of key neurotransmitter-related genes) and the processing of olfactory signals [indicated by the health status of OBs examined by histopathological and immunofluorescent observations and the in vivo contents of malondialdehyde (MDA) and the activity of caspase 3 (Cas-3)] were investigated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Depressant Fluoxetine Hampers Olfaction of Goldfish by Interfering with the Initiation, Transmission, and Processing of Olfactory Signals

Huang

Zhang

Han

et al. 2022

Environ. Sci. Technol.

View full text Add to dashboard Cite

The ubiquitous presence of fluoxetine (FLX) in aquatic environments poses great threat to fish species. However, little is known about its deleterious impacts on fish olfaction. In this study, the olfactory toxicity of FLX at environmentally realistic levels was assessed by monitoring the behavioral and electroolfactogram (EOG) responses to olfactory stimuli with goldfish (Carassius auratus), and the toxification mechanisms underlying the observed olfaction dysfunction were also investigated. Our results showed that the behavioral and EOG responses of goldfish to olfactory stimuli were significantly weakened by FLX, indicating an evident toxicity of FLX to olfaction. Moreover, FLX exposure led to significant alterations in olfactory initiation-related genes, suppression of ion pumps (Ca 2+ -ATPase and Na + /K + -ATPase), tissue lesions, and fewer olfactory sensory neurons in olfactory epithelium. In addition to altering the expression of olfactory transmission-related genes, comparative metabolomic analysis found that olfaction-related neurotransmitters (i.e., L-glutamate and acetylcholine) and the olfactory transduction pathway were significantly affected by FLX. Furthermore, evident tissue lesions, aggravated lipid peroxidation and apoptosis, and less neuropeptide Y were observed in the olfactory bulbs of FLX-exposed goldfish. Our findings indicate that FLX may hamper goldfish olfaction by interfering with the initiation, transmission, and processing of olfactory signals.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Depressant Fluoxetine Hampers Olfaction of Goldfish by Interfering with the Initiation, Transmission, and Processing of Olfactory Signals

Huang

Zhang

Han

et al. 2022

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Perhaps most fundamental to animal social behaviour, pollutants can directly interfere with sensory anatomy involved in social communication (e.g., visual, auditory, olfactory, and tactile senses). Various compounds from surfactants to metals, pesticides, and herbicides can damage chemoreceptors and olfactory function in fish [19,20], amphibians [21], and insects [22], greatly reducing their ability to detect cues. In extreme cases, chemical exposure can even lead to the development of new sensory anatomy.…”

Section: How Do Chemical Pollutants Impact Individuals?mentioning

confidence: 99%

Predicting the impacts of chemical pollutants on animal groups

Michelangeli

Martin

Pinter‐Wollman

et al. 2022

Trends in Ecology & Evolution

View full text Add to dashboard Cite

“…More recently another form of copper, nanoparticles (CuNPs), used in commercial applications such as anti-bacterial and anti-fungal agents in textiles and coatings, has been shown to impair fish olfactory function in rainbow trout. Analysis of olfactory organs showed that, unlike copper exposure, genes involved in olfactory transduction, neurogenesis, and immune response were all downregulated in the copper nanoparticle damaged olfactory mucosa (Razmara et al, 2021 ). This study presents yet another type of environmental contaminant that can impact olfactory-based survival of aquatic animals.…”

Section: Olfaction Climate Change and Future Evolutionmentioning

confidence: 99%

The Olfactory Tract: Basis for Future Evolution in Response to Rapidly Changing Ecological Niches

Whitlock

Palominos

2022

Front. Neuroanat.

View full text Add to dashboard Cite

Within the forebrain the olfactory sensory system is unique from other sensory systems both in the projections of the olfactory tract and the ongoing neurogenic potential, characteristics conserved across vertebrates. Olfaction plays a crucial role in behaviors such as mate choice, food selection, homing, escape from predators, among others. The olfactory forebrain is intimately associated with the limbic system, the region of the brain involved in learning, memory, and emotions through interactions with the endocrine system and the autonomic nervous system. Previously thought to lack a limbic system, we now know that teleost fishes process emotions, have exceptional memories, and readily learn, behaviors that are often associated with olfactory cues. The association of neuromodulatory hormones, and more recently, the immune system, with odor cues underlies behaviors essential for maintenance and adaptation within natural ecological niches. Increasingly anthropogenic perturbations affecting ecosystems are impacting teleost fishes worldwide. Here we examine the role of the olfactory tract as the neural basis for the integration of environmental cues and resulting behaviors necessary for the regulation of biotic interactions that allow for future adaptation as the climate spins out of control.

show abstract

Mechanism of copper nanoparticle toxicity in rainbow trout olfactory mucosa

Cited by 23 publications

References 76 publications

Anti-Depressant Fluoxetine Hampers Olfaction of Goldfish by Interfering with the Initiation, Transmission, and Processing of Olfactory Signals

Anti-Depressant Fluoxetine Hampers Olfaction of Goldfish by Interfering with the Initiation, Transmission, and Processing of Olfactory Signals

Predicting the impacts of chemical pollutants on animal groups

The Olfactory Tract: Basis for Future Evolution in Response to Rapidly Changing Ecological Niches

Contact Info

Product

Resources

About