Mechanism of cordycepin enhancing doxorubicin against hepatocellular carcinoma in vitro and in vivo

Li, Xiaomin; Wu, W.; Cao, Fenghua; Hu, Xin; Wu, Xiaoping; Fu, Junsheng

doi:10.1016/j.jff.2022.105268

Journal of Functional Foods

2022

DOI: 10.1016/j.jff.2022.105268

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Mechanism of cordycepin enhancing doxorubicin against hepatocellular carcinoma in vitro and in vivo

Xiaomin Li

W. Wu²,

Fenghua Cao³

et al.

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2024

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Cited by 2 publications

References 12 publications

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The role and mechanisms of cordycepin in inhibiting cancer cells

Yu,

Peng,

et al. 2024

Braz J Med Biol Res

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With the escalating incidence and mortality rates of cancer, there is an ever-growing emphasis on the research of anticancer drugs. Cordycepin, the primary nucleoside antibiotic isolated from Cordyceps militaris , has emerged as a remarkable agent for cancer prevention and treatment. Functioning as a natural targeted antitumor drug, cordycepin assumes an increasingly pivotal role in cancer therapy. This review elucidates the mechanisms of cordycepin in inhibiting tumor cell proliferation, inducing apoptosis, as well as its capabilities in suppressing angiogenesis and metastasis. Moreover, the immunomodulatory effects of cordycepin in cancer treatment are explored. Additionally, the current status, challenges, and future prospects of cordycepin application in clinical trials are briefly discussed. The objective is to provide a valuable reference for the utilization of cordycepin in cancer treatment.

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The role and mechanisms of cordycepin in inhibiting cancer cells

Yu,

Peng,

et al. 2024

Braz J Med Biol Res

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New perspectives on chemokines in hepatocellular carcinoma therapy: a critical pathway for natural products regulation of the tumor microenvironment

Ruishi,

Linyi,

Yunfan

et al. 2024

Front. Immunol.

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Hepatocellular carcinoma (HCC) is one of the most common primary neoplasms of the liver and one of the most common solid tumors in the world. Its global incidence is increasing and it has become the third leading cause of cancer-related deaths. There is growing evidence that chemokines play an important role in the tumor microenvironment, regulating the migration and localization of immune cells in tissues and are critical for the function of the immune system. This review comprehensively analyses the expression and activity of chemokines in the TME of HCC and describes their interrelationship with hepatocarcinogenesis and progression. Special attention is given to the role of chemokine-chemokine receptors in the regulation of immune cell accumulation in the TME. Therapeutic strategies targeting tumor-promoting chemokines or the induction/release of beneficial chemokines are reviewed, highlighting the potential value of natural products in modulating chemokines and their receptors in the treatment of HCC. The in-depth discussion in this paper provides a theoretical basis for the treatment of HCC. It is an important reference for new drug development and clinical research.

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Mechanism of cordycepin enhancing doxorubicin against hepatocellular carcinoma in vitro and in vivo

Cited by 2 publications

References 12 publications

The role and mechanisms of cordycepin in inhibiting cancer cells

The role and mechanisms of cordycepin in inhibiting cancer cells

New perspectives on chemokines in hepatocellular carcinoma therapy: a critical pathway for natural products regulation of the tumor microenvironment

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