Mechanism of Development of Arterial Hypertension Associated with the Exchange of Level Vitamin D

Abstract

Arterial hypertension (AH) is one of the most chronic and fatal disorders in the world, the main risk factors for which are age, hereditary predisposition, race, tobacco use, high salt intake, etc., as well as low vitamin D. In the last 10 years, there has been an increasing interest in the extraosseous effects of vitamin D. Being a hormone-like vitamin, it participates in many vital processes of the body. Its level is closely related to various metabolic disorders, diseases of the cardiovascular system (CVS), arterial hypertension (AH), diabetes mellitus, the immune system, cancer, etc. Vitamin D improves vascular endothelial function, due to which it has a vasoprotective effect, improves blood pressure, reduces vascular and myocardial remodeling, reduces the risk of left ventricular hypertrophy, slows down fibrosis, reduces the risk of atherosclerosis, reduces insulin resistance and inflammation, and improves immunity. It has been proven that vitamin D has an inverse relationship with renin, it reduces the expression of the renin gene. At a normal level of vitamin D, the concentration of renin and aldosterone II decreases, which has a positive effect on the course of hypertension.