Mechanism of diffusion of compounds through ethylene vinyl acetate copolymers I. Kinetics of diffusion of l-chloro-4-nitrobenzene, 3,4-dimethylphenol and 4-hexylresorcinol

Pharmacological Evaluation of Membrane‐moderated Transdermal System of Glipizide

“…This could be due to the ability of these films to resist the effect of ethanol in the drug reservoir. The cumulative amount of drug permeating at the end of 24 h was increased as the VA content in the EVA rate‐controlling membranes was increased, which is in accordance with earlier reports 17–19 . As the VA content increases, the crystallinity of the polymer decreases rapidly and this could be the reason for high permeation rate observed with the EVA membrane with 19% VA 20…”

“…The cumulative amount of drug permeating at the end of 24 h was increased as the VA content in the EVA rate-controlling membranes was increased, which is in accordance with earlier reports. [17][18][19] As the VA content increases, the crystallinity of the polymer decreases rapidly and this could be the reason for high permeation rate observed with the EVA membrane with 19% VA. 20 With regard to the cumulative amount of glibenclamide permeated per cm 2 of transdermal devices with ERL, ERS and EC ratecontrolling membranes through the mouse skin, when plotted against time, the permeation profiles seem to follow mixed-order/apparent zero-order kinetics. A high amount of drug was released in the initial hours because of the increased permeability of the membranes caused by ethanol.…”

Adsorptive Stripping Voltammetric Determination of 4‐Hexylresorcinol in Pharmaceutical Products Using Multiwalled Carbon Nanotube Based Electrodes

“…This method is also extended to the use of a MWCNT modified screen-printed electrode (MWCNT-SPE), thereby demonstrating that this approach can easily be incorporated into a facile and inexpensive electrochemical sensor.Keywords: 4-Hexylresorcinol, Multiwalled carbon nanotubes, Basal-plane pyrolytic graphite electrodes, Screenprinted electrode, Adsorptive stripping voltammetry, Cyclic voltammetry DOI: 10.1002/elan.200804258 4-Hexylresorcinol is a phenol found in several pharmaceutical preparations [1,2] which exploit its bacteriocidal [3 -5], anesthetic [6,7], antiseptic [8], and antihelmintic [9] properties. 4-Hexylresorcinol has been also used as an additive in the food industry [10 -12] in the treatment of certain sea foods, for example, lobsters, shrimp, prawns, and crab [13 -15].…”

Assessment of a Five-Layer Laminate Technique to Measure the Saturation Solubility of Drug in Pressure-Sensitive Adhesive Film

“…This low rate of uptake into the acceptor with no overshoot means that the EVA‐separating membrane must be much less permeable for tamsulosin than is the Perthese‐separating membrane of Figure 3a under otherwise identical conditions. Measured diffusivities for drugs of molecular weight of 500 or less in EVA membranes lie in the range of 10 −11 cm 2 /s 19. These are therefore some three orders of magnitude less than in silicone elastomer membranes (10 −8 cm 2 /s)12 and similar to those in Duro Tak 13.…”