Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains.

Okazaki, Reiji; Okazaki, Tuneko; Sakabe, K.; Sugimoto, Kazunori; Sugino, Akio

doi:10.1073/pnas.59.2.598

Cited by 368 publications

(151 citation statements)

References 16 publications

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“…They might be the DNA sequences that direct the assembly of a primosome, which may function for, most probably, the synthesis of Okazaki fragments [27] or for the reinitiation in the ss-DNA region when replication is terminated prematurely. A more interesting possibility is that sit signals might be related to DNA replication in the absence of de novo protein synthesis.…”

Section: Discussionmentioning

confidence: 99%

Identification of single‐strand initiation signals in the terC region of the Escherichia coli chromosome

1989

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On the basis of clear-plaque formation, we detected initiation signals in the terC region of the Escherichia coli chromosome. At least two single-strand initiation signals were identified from the terC region. The nucleotide sequences of these two signals were determined. Sequence homologies, variations of the consensus sequence of n' protein recognition sites, 5'-GAAGCGG-3', were found within these signals. A novel conserved sequence was also found within these signals. Their initiation activities were measured both by the infection growth assay and by the ability to convert the single-stranded DNA to the duplex replicative form DNA in vivo.

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Section: Discussionmentioning

confidence: 99%

Identification of single‐strand initiation signals in the terC region of the Escherichia coli chromosome

1989

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“…1968 saw a great leap forward in the field of DNA replication with the discovery of Okazaki fragments in Escherichia coli [4], and this was followed by a similar claim for mammalian cells [5]. We realised however that the results obtained did not actually measure Okazaki fragments but were instead a consequence of a labelling artefact.…”

Section: Phd and Postdoc: London Tennessee And Sussexmentioning

confidence: 95%

DNA repair, DNA replication and human disorders: A personal journey

Lehmann

2012

DNA Repair

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“…The mechanical problems involved in semiconservative replication of a circular duplex DNA molecule have been discussed by many authors (38,39,51,55,73,100,111,122,139,178,188,202). The replicating molecule has two discontinuities, the growth point and the origin (Fig.…”

Section: Dna Replicationmentioning

confidence: 99%