Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs

Zhou, Yongfeng; Wang, Junnan; Zhang, Dingkun; Liu, Jiaxin; Wu, Qinghua; Jiang, Chen; Tan, Peng; Xing, Boyu; Han, Yanzhong; Zhang, Ping; Xiao, Xiaohe; Pei, Jin

doi:10.1186/s13020-021-00543-x

Cited by 36 publications

(13 citation statements)

References 181 publications

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“…Natural products are a treasure trove of drugs worth developing and utilizing. In the future, investigating new drugs using natural products as the source will be one of the critical approaches for AILI treatment (Zhou et al, 2021). The various components of natural medicines provide multiple targets for disease treatment.…”

Section: Management Of Ailimentioning

confidence: 99%

Advances in the study of acetaminophen-induced liver injury

Chen

2023

Front. Pharmacol.

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Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury and acute liver failure. The diagnosis, screening, and management of APAP-induced liver injury (AILI) is challenging because of the complex mechanisms involved. Starting from the current studies on the mechanisms of AILI, this review focuses on novel findings in the field of diagnosis, screening, and management of AILI. It highlights the current issues that need to be addressed. This review is supposed to summarize the recent research progress and make recommendations for future research.

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Section: Management Of Ailimentioning

confidence: 99%

Advances in the study of acetaminophen-induced liver injury

Chen

2023

Front. Pharmacol.

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“…DILI accounts for 10% of all hepatitis cases and is the leading cause of acute liver failure in the USA [ 16 ]. Recent studies have shown that certain drugs are associated with DILI [ 17 ]. 5-ASA is generally considered a safe drug with few side effects.…”

Section: Discussionmentioning

confidence: 99%

5-Aminosalicylic Acid-Induced Liver Injury in a Patient with Ulcerative Colitis: A Case Report

Watanabe,

Nishida,

Osugi

et al. 2024

Case Rep Gastroenterol

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Introduction: Drug-induced liver injury (DILI) associated with 5-aminosalicylic acid (5-ASA) is a rare but potentially life-threatening adverse event. Case Presentation: We report the case of a 58-year-old woman with ulcerative colitis who developed DILI after initiating maintenance therapy with the multimatrix system 5-ASA. The patient presented with grade 4 liver enzyme elevation on day 98 after initiating 5-ASA and was admitted to the hospital. Blood tests revealed the mixed liver injury, and imaging studies showed no abnormalities except for mild lymph node enlargement. Liver biopsy revealed acute lobular hepatitis with interfacial activity. The patient’s score on the International Autoimmune Hepatitis Group 1999 revised scoring system was a total score of 10, causing a suspicion for the diagnosis of autoimmune hepatitis. The DDW-J 2004 scale calculated a total score of six, indicating a high probability of DILI. We suspected DILI due to 5-ASA, and the 5-ASA formulations were discontinued. The patient was treated with ursodeoxycholic acid and neominophagen C, and her liver function gradually improved without steroid treatment. Finally, we definitively diagnosed DILI based on the pathological findings and clinical course after discontinuation of 5-ASA. Conclusion: This case highlights the importance of monitoring liver function in patients receiving 5-ASA therapy.

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“…Natural medicines containing flavonoids and other functional components, particularly polyphenols, are increasingly used in clinical therapy [ 52 ]. In the elderly population with chronic diseases such as hypertension, hyperlipidemia [ 53 ], and hyperuricemia, it is common to use prescription drugs, over-the-counter drugs, and natural products simultaneously [ 47 , 54 ].…”

Section: Oat3 and Herb–drug Interactions (Hdis)mentioning

confidence: 99%

Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3

Cao

Wang

et al. 2023

Molecules

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Organic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate. This review summarizes drug–drug interactions (DDIs) and herbal–drug interactions (HDIs) mediated by OAT3, and inhibitors of OAT3 in natural active compounds in the past decade. This provides a valuable reference for the combined use of substrate drugs/herbs for OAT3 in clinical practice in the future and for the screening of OAT3 inhibitors to avoid harmful interactions.

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Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs

Cited by 36 publications

References 181 publications

Advances in the study of acetaminophen-induced liver injury

Advances in the study of acetaminophen-induced liver injury

5-Aminosalicylic Acid-Induced Liver Injury in a Patient with Ulcerative Colitis: A Case Report

Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3

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