Mechanism of Emodin in the Treatment of Rheumatoid Arthritis

Cheng, Lianying; Chen, Jie; Rong, Xiaofeng

doi:10.1155/2022/9482570

Cited by 13 publications

(4 citation statements)

References 167 publications

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“… 64 Emodin inhibited spinal inflammatory reaction, alleviated arthritis pain, 65 and suppressed inflammatory responses by controlling differentiation and maturation of T lymphocytes, dendritic cells, and regulatory T cells, reducing neutrophil infiltration in synovial tissues. 66 , 67 Catechin upregulated expression of PGE2 receptor (EP2), modulated cyclic adenosine monophosphate (cAMP) levels and inhibited secretion of IL-1 and TNF-α in rats with adjuvant arthritis. 68 Therefore, all these findings offer the possibility that myricetin, quercetin, salidroside, (-)-catechin, and emodin may be the candidate active components in JGL.…”

Section: Discussionmentioning

confidence: 99%

Integrated Network Pharmacology and Experimental Approach to Investigate the Protective Effect of Jin Gu Lian Capsule on Rheumatoid Arthritis by Inhibiting Inflammation via IL-17/NF-κB Pathway

Chen,

Li,

Lian

et al. 2023

DDDT

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This study aimed to investigate the main pharmacological action and underlying mechanisms of Jin Gu Lian Capsule (JGL) against rheumatoid arthritis (RA) based on network pharmacology and experimental verification. Methods: Network pharmacology approaches were performed to explore the core active compounds of JGL, key therapeutic targets, and signaling pathways. Molecular docking was used to predict the binding affinity of compounds with targets. In vivo experiments were undertaken to validate the findings from network analysis. Results: A total of 52 targets were identified as candidate JGL targets for RA. Sixteen ingredients were identified as the core active compounds, including, quercetin, myricetin, salidroside, etc. Interleukin-1 beta (IL1B), transcription factor AP-1 (JUN), growthregulated alpha protein (CXCL1), C-X-C motif chemokine (CXCL)3, CXCL2, signal transducer and activator of transcription 1 (STAT1), prostaglandin G/H synthase 2 (PTGS2), matrix metalloproteinase (MMP)1, inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) and transcription factor p65 (RELA) were obtained as the key therapeutic targets. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that the efficacy of JGL was functionally involved in regulating immune-mediated inflammation, in which IL-17/NF-κB signaling was recommended as one of the main pathways. Molecular docking suggested that the core active compounds bound strongly to their respective targets. Experimentally, JGL treatment mitigated inflammation, showed analgesic activity, and ameliorated collagen-induced arthritis. Enzyme-linked immunosorbent assay showed that JGL effectively reduced the serum levels of cytokines, chemokines, and MMPs. Immunohistochemistry staining showed that JGL markedly reduced the expression of the targets in IL-17/NF-κB pathway including IL-17A, IL-17RA, NF-κB p65, C-X-C motif ligand 2, MMP1 and MMP13. Conclusion: This investigation provided evidence that JGL may alleviate RA symptoms by partially inhibiting the immune-mediated inflammation via IL-17/NF-κB pathway.

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Section: Discussionmentioning

confidence: 99%

Integrated Network Pharmacology and Experimental Approach to Investigate the Protective Effect of Jin Gu Lian Capsule on Rheumatoid Arthritis by Inhibiting Inflammation via IL-17/NF-κB Pathway

Chen,

Li,

Lian

et al. 2023

DDDT

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“…As an important factor, TGF-β has become a hotspot in the study of RA treatment (Cheng et al, 2022). The interplay of SPARC with TGF-β is shown in Figure 3.…”

Section: Figurementioning

confidence: 99%

SPARC: a potential target for functional nanomaterials and drugs

Jiang

Sun

et al. 2023

Front. Mol. Biosci.

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Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or BM-40, is a matricellular protein which regulates cell adhesion, extracellular matrix production, growth factor activity, and cell cycle. Although SPARC does not perform a structural function, it, however, modulates interactions between cells and the surrounding extracellular matrix due to its anti-proliferative and anti-adhesion properties. The overexpression of SPARC at sites, including injury, regeneration, obesity, cancer, and inflammation, reveals its application as a prospective target and therapeutic indicator in the treatment and assessment of disease. This article comprehensively summarizes the mechanism of SPARC overexpression in inflammation and tumors as well as the latest research progress of functional nanomaterials in the therapy of rheumatoid arthritis and tumors by manipulating SPARC as a new target. This article provides ideas for using functional nanomaterials to treat inflammatory diseases through the SPARC target. The purpose of this article is to provide a reference for ongoing disease research based on SPARC-targeted therapy.

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“…IL-6 plays an important role in the development of RA ( Cheng et al, 2022 ), and it is associated with inflammatory response and cartilage loss in the pathogenesis of OA ( Hou et al, 2020 ). IL-10 is an important anti-inflammatory and immunosuppressive cytokine that not only prevents the occurrence of arthritis, but also has an inhibitory effect on the development of arthritis ( Charbonnier et al, 2010 ).…”

Section: Deep Exploration Based On Potential Therapeutic Targets For ...mentioning

confidence: 99%

Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms

Tian

Guo

et al. 2023

Front. Pharmacol.

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Arthritis is a common degenerative disease of joints, which has become a public health problem affecting human health, but its pathogenesis is complex and cannot be eradicated. Coptis chinensis (CC) has a variety of active ingredients, is a natural antibacterial and anti-inflammatory drug. In which, berberine is its main effective ingredient, and has good therapeutic effects on rheumatoid arthritis (RA), osteoarthritis (OA), gouty arthritis (GA). RA, OA and GA are the three most common types of arthritis, but the relevant pathogenesis is not clear. Therefore, molecular mechanism and prevention and treatment of arthritis are the key issues to be paid attention to in clinical practice. In general, berberine, palmatine, coptisine, jatrorrhizine, magnoflorine and jatrorrhizine hydrochloride in CC play the role in treating arthritis by regulating Wnt1/β-catenin and PI3K/AKT/mTOR signaling pathways. In this review, active ingredients, targets and mechanism of CC in the treatment of arthritis were expounded, and we have further explained the potential role of AHR, CAV1, CRP, CXCL2, IRF1, SPP1, and IL-17 signaling pathway in the treatment of arthritis, and to provide a new idea for the clinical treatment of arthritis by CC.

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Mechanism of Emodin in the Treatment of Rheumatoid Arthritis

Cited by 13 publications

References 167 publications

Integrated Network Pharmacology and Experimental Approach to Investigate the Protective Effect of Jin Gu Lian Capsule on Rheumatoid Arthritis by Inhibiting Inflammation via IL-17/NF-κB Pathway

Integrated Network Pharmacology and Experimental Approach to Investigate the Protective Effect of Jin Gu Lian Capsule on Rheumatoid Arthritis by Inhibiting Inflammation via IL-17/NF-κB Pathway

SPARC: a potential target for functional nanomaterials and drugs

Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms

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