Mechanism of enterovirus involvement in epidemic neuropathy: hypothesis regarding pathophysiology

Lago, Pedro Más; Guzmán, María G.; Sarmiento, Luis; Perez, A.; Alvarez, Maritza; Capó, Virginia; Avalos, I; Flores, Gustavo Kourí

doi:10.1054/mehy.2000.1222

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Concerning enterovirus, measles and parvovirus B19, the formation of epitopes with the potential to mediate an autoimmune response after the reactivation of the latent virus (in the neural cells), has been proved experimentally. This could be a second potential mechanism explaining neurological involvement [6,23].…”

Section: Resultsmentioning

confidence: 96%

Acute isolated velopharyngeal insufficiency in children: case report and systematic review of the literature

Walter

Nisa

Leuchter

2012

Eur Arch Otorhinolaryngol

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Acute isolated velopharyngeal insufficiency (VPI) is a clinical entity mainly reported in children. We undertook a systematic review in order to better characterize its features. Following a Medline search (1960-2012), the authors reviewed and analyzed the cases of acute VPI in children; 36 cases were found. The most common presenting features were hypernasal speech (97 %), nasal reflux (73 %), and dysphagia (49 %). 73 % of the children were males and 27 % females, of 8.9 ± 2.5 years. In all the cases the VPI was unilateral. One quarter of the children had a recent episode of febrile illness and 11 % of the children had an identified infection at the time of presentation (HAV, parvovirus B19, measles, and Coxsackie virus). No associated cause was found in the other cases. All cases resolved completely (67 %) or partially (33 %) without any treatment (89 %) or with prednisolone (11 %). Acute VPI represents a separate entity within the spectrum of VPI and it is a benign self-limiting disorder. The cause remains undetermined but an infectious disorder may play a role at least in some cases. Follow-up is mandatory in order to eliminate progressive conditions such as brainstem neoplasms or inflammatory diseases.

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Section: Resultsmentioning

confidence: 96%

Acute isolated velopharyngeal insufficiency in children: case report and systematic review of the literature

Walter

Nisa

Leuchter

2012

Eur Arch Otorhinolaryngol

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“…Investigation of the Cuban epidemic revealed an association with tobacco use, especially cigars, and the following were protective: higher dietary intakes of methionine, vitamin B 12 , riboflavin and niacin, and raising chickens at home or having relatives overseas. The final two factors suggest better food availability 3 4…”

Section: Discussionmentioning

confidence: 99%

Optic neuropathy endemic in secondary school children in Dar es Salaam, Tanzania

Bowman¹,

Wedner²,

Bowman³

et al. 2009

British Journal of Ophthalmology

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Aim:To investigate the prevalence and causes of optic neuropathy, reported as epidemic in 1997, among secondary school students in Dar es Salaam, Tanzania. Patients and methods:10,892 first year students from 63 secondary schools within 30km from the base hospital were interviewed and had a visual acuity screening test. Students failing the 6/12 -line in either eye were defined as having 'poor eyesight' and referred to the base hospital where an optometrist re-tested visual acuity and refracted them. An ophthalmologist examined students with visual acuities of 6/12 or worse in either eye and visual impairment was defined as VA ofworse than 6/12 with best correction. Associations between optic neuropathy, socioeconomic status and educational results were investigated. Results:Students ages ranged from 12-22 years , mean 15.2 years and 50.6% were male. The prevalence of optic neuropathy was 0.3% (sd=0.051). The condition affected older students and was associated with the family having fewer economic possessions (car, computer,TV). Optic neuropathy accounted for 19/33 (58%) of bilateral visual impairment cases. No effect of the disease on educational performance was identified.Conclusion: Optic neuropathy remains a significant problem in this population and can now be termed endemic rather than epidemic. Further research into its causes is required.

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Reply to the Letter to the Editor ‘Cuban Epidemic Optic Neuropathy (CEON) and actual methods to measure immune response in central nervous system’

González‐Quevedo

Luis

García

et al. 2009

Euro J of Neurology

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Mechanism of enterovirus involvement in epidemic neuropathy: hypothesis regarding pathophysiology

Cited by 4 publications

References 29 publications

Acute isolated velopharyngeal insufficiency in children: case report and systematic review of the literature

Acute isolated velopharyngeal insufficiency in children: case report and systematic review of the literature

Optic neuropathy endemic in secondary school children in Dar es Salaam, Tanzania

Reply to the Letter to the Editor ‘Cuban Epidemic Optic Neuropathy (CEON) and actual methods to measure immune response in central nervous system’

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