Mechanism of escape from the antibacterial activity of metal-based nanoparticles in clinically relevant bacteria: A systematic review

Salas-Orozco, Marco Felipe; Lorenzo-Leal, Ana Cecilia; de Alba Montero, Idania; Marín, Nuria Patiño; Santana, Miguel Angel Casillas; Bach, Horacio

doi:10.1016/j.nano.2023.102715

Cited by 11 publications

(3 citation statements)

References 159 publications

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“…Thus, surrounding molecules are assumed to affect the bacterial susceptibility to graphene oxide by altering their respiratory pathways. In addition to respiratory pathways, the bacterial susceptibility to NPs is also influenced by bacterial efflux pumps, motility, chemotaxis, antioxidant systems, EPS secretion, and biofilm formation, − all of which could be influenced by surrounding molecules. , Therefore, this work reveals a ubiquitous yet underappreciated ternary interaction in which surrounding molecules impact the outcomes of nanobio interactions by altering bacterial susceptibility to NPs.…”

Section: Resultsmentioning

confidence: 94%

Bacterial Susceptibility to Ceria Nanoparticles: The Critical Role of Surrounding Molecules

Dai,

Xie,

Xiao

et al. 2024

Environ. Sci. Technol.

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Investigating the ternary relationship among nanoparticles (NPs), their immediate molecular environment, and test organisms rather than the direct interaction between pristine NPs and test organisms has been thrust into the mainstream of nanotoxicological research. Diverging from previous work that predominantly centered on surrounding molecules affecting the toxicity of NPs by modulating their nanoproperties, this study has unveiled a novel dimension: surrounding molecules altering bacterial susceptibility to NPs, consequently impacting the outcomes of nanobio interaction. The study found that adding nitrate as the surrounding molecules could alter bacterial respiratory pathways, resulting in an enhanced reduction of ceria NPs (nanoceria) on the bacterial surfaces. This, in turn, increased the ion-specific toxicity originating from the release of Ce 3+ ions at the nanobio interface. Further transcriptome analysis revealed more mechanistic details underlying the nitrate-induced changes in the bacterial energy metabolism and subsequent toxicity patterns. These findings offer a new perspective for the deconstruction of nanobio interactions and contribute to a more comprehensive understanding of NPs' environmental fate and ecotoxicity.

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Section: Resultsmentioning

confidence: 94%

Bacterial Susceptibility to Ceria Nanoparticles: The Critical Role of Surrounding Molecules

Dai,

Xie,

Xiao

et al. 2024

Environ. Sci. Technol.

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“…Metal-based nanoparticles are nanoscale particles composed of metal elements or metal compounds, which exhibit unique physical, chemical, and biological properties, showing significant cytotoxicity in a time-dependent and dose-dependent manner in cancer cells ( 103 ). Common examples include metal oxide nanoparticles, metal-organic frameworks (MOFs), and gold nanoparticles.…”

Section: Nanodrugs Exert Cancer Therapeutic Effects Through Autophagy...mentioning

confidence: 99%

Nanomedicine for cancer targeted therapy with autophagy regulation

He,

Chen,

Liu

et al. 2024

Front. Immunol.

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Nanoparticles have unique physical and chemical properties and are currently widely used in disease diagnosis, drug delivery, and new drug development in biomedicine. In recent years, the role of nanomedical technology in cancer treatment has become increasingly obvious. Autophagy is a multi-step degradation process in cells and an important pathway for material and energy recovery. It is closely related to the occurrence and development of cancer. Because nanomaterials are highly targeted and biosafe, they can be used as carriers to deliver autophagy regulators; in addition to their favorable physicochemical properties, nanomaterials can be employed to carry autophagy inhibitors, reducing the breakdown of chemotherapy drugs by cancer cells and thereby enhancing the drug’s efficacy. Furthermore, certain nanomaterials can induce autophagy, triggering oxidative stress-mediated autophagy enhancement and cell apoptosis, thus constraining the progression of cancer cells.There are various types of nanoparticles, including liposomes, micelles, polymers, metal-based materials, and carbon-based materials. The majority of clinically applicable drugs are liposomes, though other materials are currently undergoing continuous optimization. This review begins with the roles of autophagy in tumor treatment, and then focuses on the application of nanomaterials with autophagy-regulating functions in tumor treatment.

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“…ROS are a family of contributors or inducers of oxidative stress, which includes singlet oxygen, peroxide, hydroxyl radicals, and hydrogen peroxide, leading to oxidation or peroxidation of lipids, nuclei, proteins, or other biomolecules, resulting in dysfunction of cellular processes and eventually causing bacterial death. Moreover, ROS are also regarded as one of the key reasons for NP antibacterial mechanisms; ROS can damage the cell wall, interfere with membrane permeability, and increase the proton motive force loss so that cells internalize and take up toxic NPs and their released agents (Salas-Orozco et al 2023 ). Meanwhile, intracellular ROS also decreases periplasmic enzyme activity, which is essential for sustaining the physiological processes of bacterial cells.…”

Section: Overview Of the Antibacterial Mechanisms Of Metal Nanoparticlesmentioning

confidence: 99%

Metal-based nanoparticles in antibacterial application in biomedical field: Current development and potential mechanisms

Jiang,

Li,

et al. 2024

Biomed Microdevices

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The rise in drug resistance in pathogenic bacteria greatly endangers public health in the post-antibiotic era, and drug-resistant bacteria currently pose a great challenge not only to the community but also to clinical procedures, including surgery, stent implantation, organ transplantation, and other medical procedures involving any open wound and compromised human immunity. Biofilm-associated drug failure, as well as rapid resistance to last-resort antibiotics, necessitates the search for novel treatments against bacterial infection. In recent years, the flourishing development of nanotechnology has provided new insights for exploiting promising alternative therapeutics for drug-resistant bacteria. Metallic agents have been applied in antibacterial usage for several centuries, and the functional modification of metal-based biomaterials using nanotechnology has now attracted great interest in the antibacterial field, not only for their intrinsic antibacterial nature but also for their ready on-demand functionalization and enhanced interaction with bacteria, rendering them with good potential in further translation. However, the possible toxicity of MNPs to the host cells and tissue still hinders its application, and current knowledge on their interaction with cellular pathways is not enough. This review will focus on recent advances in developing metallic nanoparticles (MNPs), including silver, gold, copper, and other metallic nanoparticles, for antibacterial applications, and their potential mechanisms of interaction with pathogenic bacteria as well as hosts.

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Mechanism of escape from the antibacterial activity of metal-based nanoparticles in clinically relevant bacteria: A systematic review

Cited by 11 publications

References 159 publications

Bacterial Susceptibility to Ceria Nanoparticles: The Critical Role of Surrounding Molecules

Bacterial Susceptibility to Ceria Nanoparticles: The Critical Role of Surrounding Molecules

Nanomedicine for cancer targeted therapy with autophagy regulation

Metal-based nanoparticles in antibacterial application in biomedical field: Current development and potential mechanisms

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