Mechanism of Huoxue Tongluo Decoction in treatment of erectile dysfunction caused by ischemic stroke based on network pharmacology

Wang, Jisheng; Dai, Hengheng; Zhang, Kai-Ge; Cao, Kegang; Deng, Sheng; Bao, Binghao; Feng, Junlong; Meng, Fanchao; Li, Haisong; Wang, Bin

doi:10.1016/j.chmed.2021.04.016

Cited by 6 publications

(12 citation statements)

References 18 publications

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“…Based on the retrieval strategy and data collection methods described above, 1,779 literatures were retrieved from the database, including 45 English literatures. By using NoteExpress software, we eliminated repetitive literature, read the title and abstract, read the full text, layer by layer screened and identified 16 literatures [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] which were included, as depicted in Figure 1.…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…Of the included literature, 10 studies [8-10, 13, 15, 17, 19-22] described PASI scores and 6 studies [7,11,12,14,16,18] did not. Four [8,11,14,22] of all included studies were grouped using the random number table method. Nine of the 16 included studies [7, 8, 10-13, 15, 17, 20] described adverse reactions, while the other 7 studies [9,14,16,18,19,21,22] did not.…”

Section: Basic Characteristics Of the Included Literaturementioning

confidence: 99%

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Effect of Traditional Chinese Medicine on Psoriasis Vulgaris: A Meta-Analysis and Systematic Review

et al. 2022

Complement Med Res

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Background: Psoriasis is a chronic, inflammatory autoimmune skin disease that affects 2%–3% of the world’s population. Lesions are mainly found on the limbs, trunk, and scalp, but may also affect other parts of the body, and the cause is not yet known. The chronic and relapsing nature of psoriasis makes it one of the most complex and important diseases in current dermatology research. Methods: The search was conducted using PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet, Wanfang Data, VIP journals database, and Chinese biomedical literature database (CBM). The retrieval time limit was from the establishment of the database to January 2021. The quality of the selected literature were evaluated, and ReView Manager 5.3 was used for Meta-analysis after randomized controlled trials were filtered. Results: Finally, 16 randomized controlled trials involving 1967 patients were included. The total effective rate (OR =3.68,95% CI[2.73,4.95], P<0.00001), cure rate (OR =2.01, 95% CI[1.62,2.49]c, P <0.00001), and PASI score (OR =-1.83, 95% CI[-2.39, -1.26], P <0.00001) of the traditional Chinese medicine (TCM) were superior than the Diyin tablet.. Conclusion: In the treatment of psoriasis, traditional Chinese medicine (TCM) shows higher efficacy than the Diyin tablet. However, due to the limitations of the included literature, we still need more double-blind, placebo-controlled trials with large samples and multiple centers to provide high-quality clinical evidence.

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Section: Literature Search Resultsmentioning

confidence: 99%

Section: Basic Characteristics Of the Included Literaturementioning

confidence: 99%

Effect of Traditional Chinese Medicine on Psoriasis Vulgaris: A Meta-Analysis and Systematic Review

et al. 2022

Complement Med Res

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“…The exact mechanism by which IS causes ED in the human population is still unknown due to the lack of experimental evidence, but Wang et al. have shown using a rat model, through a network pharmacology screen combined with molecular experiments, that TNF, eNOS, and VEGF target proteins may be key molecular targets of IS causing ED 22 . A previous study reported that 37% of men with HF reported having ED, and that more than half of them considered that their sexual dysfunction was impacting their quality of life 23 .…”

Section: Discussionmentioning

confidence: 99%

Causal association of cardiovascular disease with erectile dysfunction: a two‐sample bidirectional Mendelian randomization analysis

Chen²,

et al. 2023

Andrology

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BackgroundThe association between cardiovascular diseases (CVD), including ischemic stroke (IS), heart failure (HF), myocardial infarction (MI), and coronary heart disease (CHD), and erectile dysfunction (ED) remains unclear from observational studies.ObjectivesWe explored the potential bidirectional association between CVD and ED by Mendelian randomization (MR).MethodsData from genome‐wide association studies for CVD in individuals with European ancestry were obtained from several databases, with 1,711,875–977,323 participants, while that for ED included 223,805 participants. We conducted univariate MR (UVMR), inverse variance‐weighting (IVW), weighted median, MR‐Egger, and multivariate MR (MVMR) analyses to explore the bidirectional causal effects between CVD and ED.ResultsUVMR indicated that IS (odds ratios [OR] = 1.34, 95% confidence interval [CI]: 1.08–1.21, P = 0.007), HF (OR = 1.36, 95% CI 1.07–1.74, P = 0.013), and CHD (OR = 1.15, 95% CI 1.09–1.18, P = 0.022) were associated with ED. By MVMR, IS estimates remained significant after accounting for combining single nucleotide polymorphisms from CVDs (OR = 1.42, 95%CI: 1.13–1.79, P = 0.002). Moreover, the effect of a genetic susceptibility to IS on ED was not mediated by type 2 diabetes or triglycerides; that of HF was not mediated by type 2 diabetes, and that of CHD was not mediated by body mass index. Bidirectional analyses showed that genetic susceptibility to ED did not confer any increased CVD risk.ConclusionsOur results, based on MR, indicated that genetic susceptibility to IS, HF, and CHD was causally associated with ED. These findings can inform prevention and intervention strategies for ED in IS, HF, and CHD patients.

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“…The gut microbiome and drugs interact during medical regimens ( Li et al., 2009 ; Shin et al., 2014 ; Feng et al., 2015 ; Liu et al., 2019 ; Yue et al., 2019 ; Wu et al., 2022 ). The in-depth study of the interactions between the gut microbiome and medicines is an important way to reveal their mechanisms ( Wang et al., 2021 ; Zhang et al., 2021 ). Due to the lack of standardized processing methods, the results from individual studies are inconsistent, and further analysis and comparison of published data are challenging.…”

Section: Introductionmentioning

confidence: 99%

“…During information processing, it is necessary to analyze the characteristics of TCM, such as the holistic philosophy, syndrome differentiation and treatment, and drug prescriptions, in order to reveal the unique relationship between TCM and the gut microbiome. Unlike chemical drugs, TCM is often composed of compound herbal prescriptions, which have the characteristics of diverse dosage forms, large dosages, complex components, and multi-target mechanisms ( Sun et al., 2013 ; Wang et al., 2021 ). The oral components of TCM with a lower bioavailability have a longer residence time within the intestine as well as more complex metabolic processes ( Gong et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Standards for Collection, Preservation, and Transportation of Fecal Samples in TCM Clinical Trials

Lian

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundUnlike chemical drugs with a single or a few kinds of active compounds, traditional Chinese medicines (TCMs)uses herbal formulas composed of numerous kinds of chemical constituents. Therefore, TCM clinical trials require unique and stricter standards for collecting, preserving, and transporting fecal samples than those used for chemical drugs. Unfortunately, there are no special standards for processing fecal samples in TCM clinical trials.MethodsWe invited interdisciplinary experts within TCM clinical trials and gut microbiome research to help formulate this standard. After more than a year’s in-depth discussion and amendments, we achieved a standard via expert interviews, literature research, questionnaire surveys, and public opinion solicitation. This standard has been reviewed and approved by the Standards Office of China of the Association of Chinese medicine.ResultsWe established a sample information processing method prior to TCM clinical sample collection, which is adapted to the unique features of TCM. The method formulates detailed processing requirements for TCM information in addition to the factors that may disturb the gut microbiome. We also constructed a set of methods for collecting, preserving, and transporting fecal samples that meet the characteristics of TCM. These methods formulate detailed operating specifications on the collection approaches, storage conditions, transportation requirements, and management of fecal samples.ConclusionsThis standard guides the information processing prior to sample collection and the standard operating procedures for the collection, preservation, and transportation of fecal samples in TCM clinical trials, which also can be used as a reference by clinicians and researchers in modern medicines.

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Mechanism of Huoxue Tongluo Decoction in treatment of erectile dysfunction caused by ischemic stroke based on network pharmacology

Cited by 6 publications

References 18 publications

Effect of Traditional Chinese Medicine on Psoriasis Vulgaris: A Meta-Analysis and Systematic Review

Effect of Traditional Chinese Medicine on Psoriasis Vulgaris: A Meta-Analysis and Systematic Review

Causal association of cardiovascular disease with erectile dysfunction: a two‐sample bidirectional Mendelian randomization analysis

Standards for Collection, Preservation, and Transportation of Fecal Samples in TCM Clinical Trials

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