Mechanism of initial distribution of blood-borne colon carcinoma cells in the liver

Mizuno, Naomi; Kato, Yukio; Shirota, Kenji; Izumi, Yuki; Irimura, Tatsuro; Harashima, Hideyoshi; Kojima, Hiroshi; Motoji, Naomi; Shigematsu, Akiyo; Sugiyama, Yuichi

doi:10.1016/s0168-8278(98)80239-0

Cited by 18 publications

(19 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is consistent with prior reports that epithelial cells (normal or malignant) separated from the stroma and neighboring epithelial cells enter an apoptotic program (57)(58)(59)(60)(61)(62)(63)(64) and have a short half-life. They die by a combination of apoptosis (64,65) and uptake by the liver (66,67) and lung (66,68,69). Apoptosis has been demonstrated in CTCs shed from both primary and recurrent breast cancer, 13 but it has not been proven for CTCs in dormancy candidates.…”

Section: Discussionmentioning

confidence: 99%

Circulating Tumor Cells in Patients with Breast Cancer Dormancy

Meng¹,

Tripathy

Frenkel

et al. 2004

Clinical Cancer Research

875

589

View full text Add to dashboard Cite

Purpose: The purpose of this study was to test the hypothesis that circulating tumor cells (CTCs) are present in patients many years after mastectomy without evidence of disease and that these CTCs are shed from persisting tumor in patients with breast cancer dormancy.Experimental Design: We searched for CTCs in 36 dormancy candidate patients and 26 age-matched controls using stringent criteria for cytomorphology, immunophenotype, and aneusomy.Results: Thirteen of 36 dormancy candidates, 7 to 22 years after mastectomy and without evidence of clinical disease, had CTCs, usually on more than one occasion. Only 1 of 26 controls had a possible CTC (no aneusomy). The statistical difference of these two distributions was significant (exact P ‫؍‬ 0.0043). The CTCs in patients whose primary breast cancer was just removed had a half-life measured in 1 to 2.4 hours. Conclusions:The CTCs that are dying must be replenished every few hours by replicating tumor cells somewhere in the tissues. Hence, there appears to be a balance between tumor replication and cell death for as long as 22 years in dormancy candidates. We conclude that this is one mechanism underlying tumor dormancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Circulating Tumor Cells in Patients with Breast Cancer Dormancy

Meng¹,

Tripathy

Frenkel

et al. 2004

Clinical Cancer Research

875

589

View full text Add to dashboard Cite

show abstract

“…[13][14][15] We have previously suggested that two important mechanisms are involved in the hepatic metastasis of KM12-HX cells. 9,10) The first mechanism is a physical trapping caused by the difference in size between cancer cells and the microvessels in liver. Therefore, this mechanism may not be a suitable target for the suppression of metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…7) KM12-HX cells are derived from human colon carcinoma and highly express sLeX sugar antigen on the cell surface. [8][9][10] This cell line exhibits final metastasis in the liver. The frequency of such metastasis depends on the cumulative amount of cancer cells extracted by the liver, much of which can be accounted for by non-specific trapping caused by them being larger than microvessels.…”

mentioning

confidence: 99%

“…The frequency of such metastasis depends on the cumulative amount of cancer cells extracted by the liver, much of which can be accounted for by non-specific trapping caused by them being larger than microvessels. 9,10) On the other hand, cell-cell interactions mediated by the sugar antigen on their surface may also play an important role in metastasis. Thus, the degree of final metastasis is determined by two factors, the first-pass trapping by microvessels and the molecular interaction mediated by sLeX antigen.…”

mentioning

confidence: 99%

“…Thus, the degree of final metastasis is determined by two factors, the first-pass trapping by microvessels and the molecular interaction mediated by sLeX antigen. 9,10) Accordingly, an sLeX analog may suppress the final metastasis of cancer cells by inhibiting the latter mechanism without having any effect on the former. In the present study, we investigated the antimetastatic effect of GSC-150 on the hepatic metastasis of KM12-HX cells to demonstrate the importance of these two factors in metastasis.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Anti-metastatic Effect of the Sialyl Lewis-X Analog GSC-150 on the Human Colon Carcinoma Derived Cell Line KM12-HX in the Mouse.

Shirota

Kato

Irimura

et al. 2001

Biological & Pharmaceutical Bulletin

Self Cite

View full text Add to dashboard Cite

We investigated the inhibitory effect of the sialyl Lewis-X (sLeX) analog, GSC-150, on hepatic metastasis of the human colon carcinoma derived cell line, KM12-HX, which highly expresses sLeX antigen on the cell surface. The number of cancer nodules found in BALB/c nude mouse liver 6 weeks after intrasplenic injection of KM12-HX cells was significantly reduced by co-administration of GSC-150. The amount of

show abstract

Numerical Simulations of Stochastic Circulatory Models

Wimmer

Dedik

Michal

et al. 1999

Bulletin of Mathematical Biology

View full text Add to dashboard Cite

Properties of two of the stochastic circulatory models theoretically introduced by Smith et al., 1997, Bull. Math. Biol. 59, 1-22 were investigated. The models assumed the gamma distribution of the cycle time under either the geometric or Poisson elimination scheme. The reason for selecting these models was the fact that the probability density functions of the residence time of these models are formally similar to those of the Bateman and gamma-like function models, i.e., the two common deterministic models. Using published data, the analytical forms of the probability density functions of the residence time and the distributions of the simulated values of the residence time were determined on the basis of the deterministic models and the stochastic circulatory models, respectively. The Kolmogorov-Smirnov test revealed that even for 1000 xenobiotic particles, i.e., a relatively small number if the particles imply drug molecules, the probability density functions of the residence time based on the deterministic models closely matched the distributions of the simulated values of the residence time obtained on the basis of the stochastic circulatory models, provided that parameters of the latter models fulfilled selected conditions.

show abstract

Mechanism of initial distribution of blood-borne colon carcinoma cells in the liver

Cited by 18 publications

References 18 publications

Circulating Tumor Cells in Patients with Breast Cancer Dormancy

Circulating Tumor Cells in Patients with Breast Cancer Dormancy

Anti-metastatic Effect of the Sialyl Lewis-X Analog GSC-150 on the Human Colon Carcinoma Derived Cell Line KM12-HX in the Mouse.

Numerical Simulations of Stochastic Circulatory Models

Contact Info

Product

Resources

About