Mechanism of lncRNA-H19 in Intestinal Injury of Mice with Ulcerative Colitis

Yin, Li; Yan, Jun; Chen, Wei

doi:10.1159/000524156

Cited by 5 publications

(1 citation statement)

References 29 publications

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“…Moreover, H19 is involved in the STAT3 pathway, which is critical for cancer aggressiveness, potentially impacting the tumor microenvironment. Therefore, the examination of H19 in the context of CRC could yield valuable insights into tumorigenesis, inflammation, and potential therapeutic strategies [ 105 , 106 , 107 ].…”

Section: The Role Of Lncrnas In Tumor–stroma Immune Interplay Via Ext...mentioning

confidence: 99%

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Shakhpazyan,

Mikhaleva,

Bedzhanyan

et al. 2023

Biomedicines

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This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in the pathogenesis of CRC, immune evasion, and the treatment response to CRC, have crucial implications in inflammation and serve as promising candidates for novel therapeutic strategies and biomarkers. This review scrutinizes the interaction of lncRNAs with the Consensus Molecular Subtypes (CMSs) of CRC, their complex interplay with the tumor stroma affecting immunity and inflammation, and their conveyance via extracellular vesicles, particularly exosomes. Furthermore, we delve into the intricate relationship between lncRNAs and other non-coding RNAs, including microRNAs and circular RNAs, in mediating cell-to-cell communication within the CRC microenvironment. Lastly, we propose potential strategies to manipulate lncRNAs to enhance anti-tumor immunity, thereby underlining the significance of lncRNAs in devising innovative therapeutic interventions in CRC.

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Section: The Role Of Lncrnas In Tumor–stroma Immune Interplay Via Ext...mentioning

confidence: 99%

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Shakhpazyan,

Mikhaleva,

Bedzhanyan

et al. 2023

Biomedicines

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Serum long noncoding RNA H19/micro RNA-675-5p axis as a probable diagnostic biomarker in inflammatory bowel disease

Shaker,

Safa,

Khairy

et al. 2023

Mol Biol Rep

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Background A significant body of research strengthens the starring role of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the pathogenesis of inflammatory bowel disease (IBD). Here, we investigated the diagnostic utility of lncRNA H19 and miRNA-675-5p in IBD. Methods This study included 97 participants, thirty-five ulcerative colitis patients, thirty-two Crohn’s disease patients, and thirty IBD-free controls. History, staging, laboratory investigations, and colonoscopy were performed. Also, quantitative real-time PCR (qPCR) for revealing of lncRNA H19 and miRNA-675-5p was done. Results The estimated serum levels for H19 and miRNA-675-5p in the UC and CD groups in comparison to the control group showed a high statistical difference (P = 0.0001 for each parameter). Based upon the severity of UC patients, both biomarkers showed significantly higher values between remission and moderate cases, with p-values 0.022 and 0.02, respectively. Meanwhile, in CD patients, both biomarkers revealed no statistical significance between remission and any active stage of the disease. Additionally, ROC analysis revealed that H19 could discriminate between UC and control subjects with 94.3% sensitivity and 90.0% specificity, and with 87.5% sensitivity, and 88.5% specificity in the CD group. Furthermore, miR-675-5p was able to discriminate between UC and control subjects with 85.7% sensitivity and 97.3% specificity and with 88.4% sensitivity, 95.2% specificity in the CD group. Logistic regression found a significant predictive utility of using miR-675-5p and H19 in IBD. Conclusion H19 and miRNA-675-5p can be used as diagnostic biomarkers in IBD, with superiority in UC patients with moderate activity.

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Non-coding RNAs: Emerging biomarkers and therapeutic targets in ulcerative colitis

Kazmi,

Altamimi,

Afzal

et al. 2024

Pathology - Research and Practice

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Mechanism of lncRNA-H19 in Intestinal Injury of Mice with Ulcerative Colitis

Cited by 5 publications

References 29 publications

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Serum long noncoding RNA H19/micro RNA-675-5p axis as a probable diagnostic biomarker in inflammatory bowel disease

Non-coding RNAs: Emerging biomarkers and therapeutic targets in ulcerative colitis

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