Mechanism of miR‐137 regulating migration and invasion of melanoma cells by targeting PIK3R3 gene

Jia, Qi; Wang, Wei‐wei; Chen, Wei; Lu, Wenying; Shang, Anquan

doi:10.1002/jcb.28124

Cited by 16 publications

(11 citation statements)

References 22 publications

(40 reference statements)

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“…miR-137 expression has been shown to correlate with poor survival in stage IV melanoma patients [93]. Multiple oncogenic target mRNAs, including c-MET (mesenchymal to epithelial transition), YB1 (Y box-binding protein 1), EZH2 (enhancer of zeste homolog 2), and PIK3R3 (phosphatidylinositol 3 kinase regulatory 3) are downregulated by miR-137 [94]. miR-148 has been reported to negatively regulate MITF expression in melanoma cells through a conserved binding site in the 3′UTR sequence [95].…”

Section: Mirnas Modulate Melanoma Cell Invasionmentioning

confidence: 99%

Role of miRNAs in Melanoma Metastasis

Gajos-Michniewicz

Czyż

2019

Cancers

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Tumour metastasis is a multistep process. Melanoma is a highly aggressive cancer and metastasis accounts for the majority of patient deaths. microRNAs (miRNAs) are non-coding RNAs that affect the expression of their target genes. When aberrantly expressed they contribute to the development of melanoma. While miRNAs can act locally in the cell where they are synthesized, they can also influence the phenotype of neighboring melanoma cells or execute their function in the direct tumour microenvironment by modulating ECM (extracellular matrix) and the activity of fibroblasts, endothelial cells, and immune cells. miRNAs are involved in all stages of melanoma metastasis, including intravasation into the lumina of vessels, survival during circulation in cardiovascular or lymphatic systems, extravasation, and formation of the pre-metastatic niche in distant organs. miRNAs contribute to metabolic alterations that provide a selective advantage during melanoma progression. They play an important role in the development of drug resistance, including resistance to targeted therapies and immunotherapies. Distinct profiles of miRNA expression are detected at each step of melanoma development. Since miRNAs can be detected in liquid biopsies, they are considered biomarkers of early disease stages or response to treatment. This review summarizes recent findings regarding the role of miRNAs in melanoma metastasis.

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Section: Mirnas Modulate Melanoma Cell Invasionmentioning

confidence: 99%

Role of miRNAs in Melanoma Metastasis

Gajos-Michniewicz

Czyż

2019

Cancers

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“…For example, miR-137 suppresses melanoma growth by targeting aurora kinase A (Chang, Zhang, Lian, & Zhu, 2016). Several studies verify the growth inhibitory effect of miR-137 on melanoma cells by targeting PIK3R3 (Qi, Wang, Chen, Lu, & Shang, 2018), PAK2 (Hao et al, 2015), and GLO1 (Lv et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Propofol suppresses proliferation, invasion, and migration of human melanoma cells via regulating microRNA‐137 and fibroblast growth factor 9

Zhou

et al. 2019

Journal Cellular Physiology

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Propofol is an intravenous anesthetic widely used in clinical surgeries, such as tumor resection. Propofol affects the growth of many cancers, though its effect on melanoma is unknown. Our study aimed to explore how propofol affects melanoma cells. Melanoma cells A2058 and WM793B were cultured with propofol for 24 hr.Propofol significantly suppressed proliferation, migration, and invasion of A2058 and WM793B cells. Lower miR-137 level was observed in A2058 and WM793B cells, compared with normal human epidermal melanocyte HEMa-LP cells. Propofolinduced miR-137 upregulation and decreased proliferation, invasive ability, and migrated ability of A2058 and WM793B cells. Transfection with the miR-137 inhibitor reversed these effects. Additionally, miR-137 was verified to target and negatively regulate fibroblast growth factor 9 (FGF9) expression. Propofol efficiently downregulated FGF9 protein expression by upregulating miR-137. Furthermore, FGF9 overexpression abrogated propofol's repressive effects on the malignant potential of A2058 and WM793B cells. These findings indicate that propofol suppressed melanoma cell proliferation, invasion, and migration by regulating miR-137 and FGF9.

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“…The hsa_miR_429 is downregulated and could reduce the migration ability of HCC cells by targeting the RAB23 gene [29]. Meanwhile, hsa_miR_137 could directly target with the PIK3R3 gene and inhibit its function, thereby suppressing the migration and invasion of tumor cells [30]. Given these relevant evidence, the central circRNAs and miRNAs were speculated to be potential biomarkers for BCa treatment.…”

Section: Discussionmentioning

confidence: 99%

Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis

Chang²,

et al. 2021

International Journal of Genomics

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In recent years, increasing evidence shows that circular RNA (circRNA) disorder is closely related to tumorigenesis and cancer progression. However, the regulatory functions of most circRNAs in bladder cancer (BCa) remain unclear. This study was aimed at exploring the molecular regulatory mechanism of circRNAs in BCa. We obtained four datasets of circRNA, microRNA (miRNA), and messenger (mRNA) expression profiles from the Gene Expression Omnibus and The Cancer Genome Atlas microarray databases and identified 434, 367, and 4799/4841 differentially expressed circRNAs, miRNAs, and mRNAs, respectively. With these differentially expressed RNAs, we established a circRNA-miRNA-mRNA targeted interaction network. A total of 18, 24, and 51 central circRNAs, miRNAs, and mRNAs were identified, respectively. Among them, the top 10 mRNAs that had high connectivity with other circRNAs and miRNAs were regarded as hub genes. We detected the expression levels of these 10 mRNAs in 16 pairs of BCa tissues and adjacent normal tissues through quantitative real-time polymerase chain reaction. The differentially expressed mRNAs and central mRNAs were enriched in the processes and pathways that are associated with the growth, differentiation, proliferation, and apoptosis of tumor cells. The outstanding genes (CDCA4, GATA6, LATS2, RHOB, ZBTB4, and ZFPM2) also interacted with numerous drugs, indicating their potency as biomarkers and drug targets. The findings of this study provide a deep understanding of the circRNA-related competitive endogenous RNA regulatory mechanism in BCa pathogenesis.

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Mechanism of miR‐137 regulating migration and invasion of melanoma cells by targeting PIK3R3 gene

Cited by 16 publications

References 22 publications

Role of miRNAs in Melanoma Metastasis

Role of miRNAs in Melanoma Metastasis

Propofol suppresses proliferation, invasion, and migration of human melanoma cells via regulating microRNA‐137 and fibroblast growth factor 9

Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis

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