“…Firstly by neutralising the acid gastric contents, they relieve pain. This was demonstrated physiologically by injecting acid and alkaline solutions in the stomachs of patients with active ulcers (Bonney and Pickering, 1946;review by Pickering, 1952 ;Palmer and Heinz , 1934) and also in clinical trials (Lawrence , 1952). Secondly, it was hoped that by maintaining the pH of the gastric contents above the pH level where pepsin is active, peptic ulceration would be physiologically impossible.…”