1989
DOI: 10.2177/jsci.12.156
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Mechanism of persistent hypocomplementemia in systemic lupus erythematosus. Analysis of plasma C3a and C4a.

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Cited by 2 publications
(2 citation statements)
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“…In the setting of SSc, Tokiyama et al. were among the first ones to report EGFR abnormalities in SSc fibroblasts including decreased affinity for EGF, higher levels of RNA for EGFR gene and decrease response to transretinoic acid . More recently, Arts et al.…”
Section: Discussionmentioning
confidence: 99%
“…In the setting of SSc, Tokiyama et al. were among the first ones to report EGFR abnormalities in SSc fibroblasts including decreased affinity for EGF, higher levels of RNA for EGFR gene and decrease response to transretinoic acid . More recently, Arts et al.…”
Section: Discussionmentioning
confidence: 99%
“…As shown in the figure the I-that is, concentration of serum complements in patients 7) U/ml in with a negative CR1 was significantly lower (10) U/ml than those in patients with a positive CR1, and ie of C4 in in group II, the change in CR1 from negative to gnificantly positive was accompanied by an increase in i group I serum complement. The existence of potential (50) mg/l complement activation has been described even in patients with SLE in clinical remission.26 27 28 The erythrocyte CR1 may have a functional role in the removal of circulating immune complexes and this process would depend on complement consumption. Therefore, even if the genotypes are homozygous for the 7T4 kb allele, the CR1 activities may be negative as long as immunological disorders remain and the complement concentrations are low.…”
Section: Rationsmentioning
confidence: 99%