Mechanism of pH-switchable peroxidase and catalase-like activities of gold, silver, platinum and palladium

Li, Junnan; Liu, Wenqi; Wu, Xiaochun; Gao, Xingfa

doi:10.1016/j.biomaterials.2015.01.012

Cited by 452 publications

(371 citation statements)

References 55 publications

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“…The surface of nanoparticles is prone to adsorption of protons and hydroxyl anion, which can significantly change the character of the active sites and affect the performance and even the nature of the conducted catalysis [23]. In order to evaluate the influence of pH on hydrogen peroxide affinity to the applied catalyst, a series of K M values for the same hydrogen donor at different pH were calculated.…”

Section: Resultsmentioning

confidence: 99%

“…The superficial redox activity of gold NPs gives a number of possibilities of their use as enzyme mimics for the assay systems. The catalytic activities of NPS can be tailored according to the availability of substrates and the process conditions [2, 22, 23]. Increased attention has been paid to polymer-stabilized nanostructures characterized by the increased resistance to salt-induced aggregation or inactivation induced by extreme pH values.…”

Section: Introductionmentioning

confidence: 99%

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Pitfalls and capabilities of various hydrogen donors in evaluation of peroxidase-like activity of gold nanoparticles

et al. 2016

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Catalytic nanomaterials, widely used as substitutes of peroxidase, exhibit unique properties, which are unattainable for native enzymes. However, their activity is usually examined by means of substrates developed and methods standardized for horseradish peroxidase (HRP). The aim of the presented work was to determine the scope of usefulness of chromogenic substrates for gold nanoparticle (AuNP) activity studies under conditions which significantly extend beyond the activity range of a native HRP. The applicability of chromogens such as 3,3′5,5′-tetramethylbenzidine (TMB), o-phenylenediamine (OPD), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) beyond the typical range of pH, and for the samples of high concentration of hydrogen peroxide was examined. The conducted research confirmed the usefulness of ABTS and TMB in acidic media (pH 2.5–3.5). At the same time, potential interferences from chloride anion, unobservable for HRP-based assays, were indicated. Moreover, a number of potentially useful hints concerning relations of concentration of substrates and catalyst for aromatic amine oxidation (TMB and OPD) were proposed. By increasing the concentration of chromogens and thanks to assuring the relatively low conversion of the reaction, the stability of TMB and OPD oxidation product was improved even in acidic media. The comparative studies of H2O2 affinity to the surface of AuNPs in the presence of various hydrogen donors underlined the superiority of phenolic compounds over aromatic amines and ABTS in the case of the samples of relatively low H2O2 concentration. This work highlights some improvements in the methods of HRP-like activity characterization of NPs. It provides a critical analysis of the major challenges, which may emerge in a case of bioanalytical assays employing the catalytic nanoparticles as labels.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pitfalls and capabilities of various hydrogen donors in evaluation of peroxidase-like activity of gold nanoparticles

et al. 2016

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“…Through their extensive study and by comparison of the peroxidase-like activity of unmodified, amino-modified, and citrate-capped gold nanoparticles, it was revealed and confirmed that peroxidase-like activity was indeed contributed by the gold content of the nanoparticles [25]. Gold nanoparticles with different surface charges (positive or negative) have been shown to exhibit peroxidase-mimicking activity [26]. The enzyme like activities of gold nanoparticles are microenvironment dependent, and they can be changed or tuned by changing the pH or surface modification resulting in changed affinities between nanozymes and substrate.…”

Section: Types Of Nanomaterialsmentioning

confidence: 99%

“…Li et al have demonstrated pH-switchable peroxidase and catalase mimic activities of Au, Ag, Pt and Pd nanozymes on the basis of computational studies. Nanozymes exhibited peroxidase-like activities at acidic pH and catalase-like activities at basic pH [26]. Wang et al reported peroxidase-like activities of bovine serum albumin (BSA)-encapsulated fluorescent gold nanoclusters [27].…”

Section: Types Of Nanomaterialsmentioning

confidence: 99%

Nano-Engineered Biomimetic Optical Sensors for Glucose Monitoring in Diabetes

Rauf

Nawaz

Badea

et al. 2016

Sensors

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Diabetes is a rapidly growing disease that can be monitored at an individual level by controlling the blood glucose level, hence minimizing the negative impact of the disease. Significant research efforts have been focused on the design of novel and improved technologies to overcome the limitations of existing glucose analysis methods. In this context, nanotechnology has enabled the diagnosis at the single cell and molecular level with the possibility of incorporation in advanced molecular diagnostic biochips. Recent years have witnessed the exploration and synthesis of various types of nanomaterials with enzyme-like properties, with their subsequent integration into the design of biomimetic optical sensors for glucose monitoring. This review paper will provide insights on the type, nature and synthesis of different biomimetic nanomaterials. Moreover, recent developments in the integration of these nanomaterials for optical glucose biosensing will be highlighted, with a final discussion on the challenges that must be addressed for successful implementation of these nano-devices in the clinical applications is presented.

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“…Therefore, the development of materials with intrinsic peroxidase-like activity opened up a new direction in the preparation of new objects, substrates, and materials. These materials include metal oxide NPs, such as CuO, 9,10 15 and FeS, 16 and noble metal NPs [17][18][19] with various content and morphologies. At this moment, the most promising materials for sensor technologies are carbon-based nanomaterials.…”

Section: -7mentioning

confidence: 99%

Iron-core/carbon-shell nanoparticles with intrinsic peroxidase activity: new platform for mimetic glucose detection

et al. 2017

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Artificial enzymatic mimics based on nanoparticles have become a powerful tool for the improvement of analytical performance in the detection of important bioactive compounds. For the first time the intrinsic peroxidase-like activity of Fe-core/carbon shell nanoparticles (Fe@C NPs) was studied. The catalytic process was described by a typical Michaelis-Menten curve for enzyme kinetics, and the results were comparable with those previously published. The high catalytic performance of the Fe@C NPs allows the development of a new simple procedure for glucose determination with a low detection limit of 0.21 mM. To our knowledge, this is the first study showing the ability to generate active oxygen species on the Fe@C surfaces. We suppose that our investigation will open up a new direction in medicinal applications using these promising materials.

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Mechanism of pH-switchable peroxidase and catalase-like activities of gold, silver, platinum and palladium

Cited by 452 publications

References 55 publications

Pitfalls and capabilities of various hydrogen donors in evaluation of peroxidase-like activity of gold nanoparticles

Pitfalls and capabilities of various hydrogen donors in evaluation of peroxidase-like activity of gold nanoparticles

Nano-Engineered Biomimetic Optical Sensors for Glucose Monitoring in Diabetes

Iron-core/carbon-shell nanoparticles with intrinsic peroxidase activity: new platform for mimetic glucose detection

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