Mechanism of polyuria and natriuresis associated with paroxysmal supraventricular tachycardia.

Abstract

SUMMARYChanges in plasma levels of atrial natriuretic peptide (ANP) and arginine vasopressin (AVP) were studied in 8 patients during a 30 min period of induced supraventricular tachycardia (SVT). The mean plasma ANP concentration increased immediately after the onset of SVT, peaked at 30 min and gradually returned to the control level. The mean plasma AVP concentration, on the other hand, was suppressed during SVT and rebounded above the control level in the post-SVT period. In 4 patients, SVT was associated with polyuric and natriuresis. The mean urine volume in these patients increased to 580% of the control and the mean urinary sodium excretion to 278% of the control, respectively. It was concluded that both a stimulation of ANP secretion and an inhibition of AVP release, elicited by an increase in atrial pressure, may be responsible for polyuria and natriuresis associated with SVT.

The diagnostic significance of NT-proBNP and troponin I in emergency department patients presenting with palpitations

“…Schiebinger et al showed that increased atrial stimulation from 120-240 beats per minute led to a significant increase in atrial natriuretic peptide secretion in isolated rat hearts (14). Qi et al observed a significant increase in BNP associated with various tachycardias in an experimental animal study (15). Some studies have shown that natriuretic peptide is increased in plasma during acute attacks of paroxysmal supraventricular tachycardia and falls rapidly after reversion to sinus rhythm (16,17).…”