Mechanism of protection induced in mice against Erysipelothrix rhusiopathiae infection by treatment with porcine antiserum to the culture filtrate of an attenuated strain

Sawada, Takuo; Tsutsumi, Yutaka; Takahashi, Toshio

doi:10.1016/0378-1135(88)90080-6

Cited by 4 publications

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References 11 publications

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“…The mechanism of immunity to E rhusiopathiae infection is not clearly defined, but humoral immunity is considered as the most important in the protection (Wood and Henderson 2006). Previous studies have shown that virulent E rhusiopathiae bacteria opsonised with immune serum were eliminated by polymorphonuclear leucocytes (Sawada and others 1988) or macrophages (Shimoji and others 1996). In contrast, non-opsonised bacteria were resistant to phagocytosis.…”

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Effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on pig humoral immune responses induced by erysipelas vaccination

et al. 2016

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It addition to their antimicrobial properties, antibiotics can influence the host immune system (modulation of cytokine secretion, antibody production and T-cell proliferation). In the present study, the authors studied the effects of therapeutic doses of amoxicillin (AMX), ceftiofur (CEF), doxycycline (DOXY), tiamulin (TIAM) and tulathromycin (TUL) on the postvaccinal immune response after pigs had been vaccinated against erysipelas. Because humoral immunity is considered as the most important in the protection against swine erysipelas, the present study focused on the interactions between antibiotics and postvaccinal humoral immunity. One hundred and five, eight-week-old pigs of both sexes were used. Specific antibodies to the Erysipelothrix rhusiopathiae antigen were determined using a commercial ELISA test. In pigs treated with DOXY or CEF or TIAM, a significant reduction in the number of positive pigs was observed four and six weeks after the second dose of vaccine, compared with the remaining vaccinated groups. In pigs treated with CEF, the ELISA score was significantly lower than in non-treated vaccinated pigs. While in vaccinated pigs treated with AMX or TUL, the ELISA score was significantly higher than in pigs treated with the remaining antibiotics and than in non-treated vaccinated controls. The results of the present study indicate that vaccination of pigs against erysipelas in the presence of antibiotics may result in a decrease (CEF, DOXY, TIAM) or enhancement (AMX, TUL) in the production of specific antibodies.

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Effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on pig humoral immune responses induced by erysipelas vaccination

et al. 2016

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Erysipelothrix Rhusiopathiae

Shimoji¹

2004

Pathogenesis of Bacterial Infections in Animals

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Types of E. coli Implicated in Disease Enterotoxigenic E. coli (ETEC) Pathogenesis Shiga Toxin-Producing Escherichia coli (STEC) Enteropathogenic E. coli (EPEC) Pathogenesis Extraintestinal E. coli (ExPEC) Immunity Concluding Remarks 17 Actinobacillus J. I. MacInnes and J. T. Bossé Actinobacillus pleuropneumoniae Actinobacillus suis Actinobacillus equuli Actinobacillus lignieresii Conclusions and Future Prospects 18 Haemophilus T. J. Inzana and L. Corbeil Characteristics Habitat and Transmission Haemophilus somnus Haemophilus parasuis Haemophilus paragallinarum Conclusions 19 Bordetella D. A. Bemis and B. Fenwick

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Effect of cyclophosphamide and carrageenan on resistance of mice to Erysipelothrix rhusiopathiae

Sawada

Tsutsumi

Takahashi

1987

Veterinary Microbiology

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Mechanism of protection induced in mice against Erysipelothrix rhusiopathiae infection by treatment with porcine antiserum to the culture filtrate of an attenuated strain

Cited by 4 publications

References 11 publications

Effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on pig humoral immune responses induced by erysipelas vaccination

Effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on pig humoral immune responses induced by erysipelas vaccination

Erysipelothrix Rhusiopathiae

Effect of cyclophosphamide and carrageenan on resistance of mice to Erysipelothrix rhusiopathiae

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