Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

Liang, Qi; Yuan, Xin; Wu, Xixi; Ao, Qiang

doi:10.3390/polym14112184

Cited by 50 publications

(28 citation statements)

References 106 publications

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“…Although the swift self‐healing rate is superior, hydrogen bonds are usually rather weaker and not stable enough compared with other reversible bonds due to the low bond energy (1.046–62.788 kJ mol −1 ). [ 198 ] Moreover, the concentration of Zn 2+ should be regulated for higher concentrations will spoil the formation of hydrogen bonds. [ 193 ]…”

Section: Versatile Flexible Aziesss Assisted By Multifunctional Hydro...mentioning

confidence: 99%

Hydrogel Electrolyte Enabled High‐Performance Flexible Aqueous Zinc Ion Energy Storage Systems toward Wearable Electronics

Weng,

Yang,

Wang

et al. 2023

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To cater to the swift advance of flexible wearable electronics, there is growing demand for flexible energy storage system (ESS). Aqueous zinc ion energy storage systems (AZIESSs), characterizing safety and low cost, are competitive candidates for flexible energy storage. Hydrogels, as quasi‐solid substances, are the appropriate and burgeoning electrolytes that enable high‐performance flexible AZIESSs. However, challenges still remain in designing suitable and comprehensive hydrogel electrolyte, which provides flexible AZIESSs with high reversibility and versatility. Hence, the application of hydrogel electrolyte‐based AZIESSs in wearable electronics is restricted. A thorough review is required for hydrogel electrolyte design to pave the way for high‐performance flexible AZIESSs. This review delves into the engineering of desirable hydrogel electrolytes for flexible AZIESSs from the perspective of electrolyte designers. Detailed descriptions of hydrogel electrolytes in basic characteristics, Zn anode, and cathode stabilization effects as well as their functional properties are provided. Moreover, the application of hydrogel electrolyte‐based flexible AZIESSs in wearable electronics is discussed, expecting to accelerate their strides toward lives. Finally, the corresponding challenges and future development trends are also presented, with the hope of inspiring readers.

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Section: Versatile Flexible Aziesss Assisted By Multifunctional Hydro...mentioning

confidence: 99%

Hydrogel Electrolyte Enabled High‐Performance Flexible Aqueous Zinc Ion Energy Storage Systems toward Wearable Electronics

Weng,

Yang,

Wang

et al. 2023

Small

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“…Investigations into self-healable hydrogels have intensified to find durable materials and stable over time for biomedical applications [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. Polymer hydrogels with shear-thinning and self-healing properties are suitable for their use in the fabrication of materials for tissue regeneration [ 30 ], cell encapsulation and delivery [ 31 ], 3D-priting for bone tissue engineering applications [ 32 ], drug delivery devices [ 33 ], in vivo applications [ 34 ], biosensors [ 35 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Advances in the Design of Phenylboronic Acid-Based Glucose-Sensitive Hydrogels

Morariu¹

2023

Polymers

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Diabetes, characterized by an uncontrolled blood glucose level, is the main cause of blindness, heart attack, stroke, and lower limb amputation. Glucose-sensitive hydrogels able to release hypoglycemic drugs (such as insulin) as a response to the increase of the glucose level are of interest for researchers, considering the large number of diabetes patients in the world (537 million in 2021, reported by the International Diabetes Federation). Considering the current growth, it is estimated that, up to 2045, the number of people with diabetes will increase to 783 million. The present work reviews the recent developments on the hydrogels based on phenylboronic acid and its derivatives, with sensitivity to glucose, which can be suitable candidates for the design of insulin delivery systems. After a brief presentation of the dynamic covalent bonds, the design of glucose-responsive hydrogels, the mechanism by which the hypoglycemic drug release is achieved, and their self-healing capacity are presented and discussed. Finally, the conclusions and the main aspects that should be addressed in future research are shown.

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“…Self-healing hydrogels have drawn much attention and demonstrated great potential to increase the repair ability compared to traditional injectable hydrogels. To ensure the strength and recovery rate of the gel, the self-healing hydrogel is mainly formed by dynamic (non)covalent bonding interactions to achieve reversible “break-formation” processes. , However, most self-healing hydrogel systems run the risk of binding to reactive groups in collagen and proteins (e.g., amine, carboxyl, hydroxyl, sulfhydryl, etc.) and the metal ions (e.g., calcium, magnesium, etc.)…”

Section: Introductionmentioning

confidence: 99%

Building a Poly(amino acid)/Chitosan-Based Self-Healing Hydrogel via Host–Guest Interaction for Cartilage Regeneration

Zong

et al. 2023

ACS Biomater. Sci. Eng.

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Cartilage injury is a very common joint disease, and cartilage repair is a great challenge in clinical treatment due to the specific structure of cartilage tissue and its microenvironment in vivo. The injectable self-healing hydrogel is a very promising candidate as a cartilage repair material because of its special network structure, high water retention and self-healing properties. In this work, a self-healing hydrogel cross-linked by host−guest interaction between cyclodextrin and cholic acid was developed. The host material was composed of β-cyclodextrin and 2-hydroxyethyl methacrylate-modified poly(Lglutamic acid) (P(LGA-co-GM-co-GC)), while the guest material was chitosan modified by cholic acid, glycidyl methacrylate, and (2,3-epoxypropyl)trimethylammonium chloride (EPTAC) (QCSG-CA). The host−guest interaction self-healing hydrogels, named as HG hydrogels (HG gel), exhibited excellent injectability and self-healable property, and the self-healing efficiency was greater than 90%. Furthermore, in order to enhance the mechanical properties and slow down the degradation of the HG gel in vivo, the second network was constructed by photo-cross-linking in situ. Biocompatibility tests showed that the enhanced multiinteraction hydrogel (MI gel) was extremely suitable for cartilage tissue engineering both in vitro and in vivo. In addition, the adipose derived stem cells (ASCs) in MI gel were able to differentiate cartilage effectively in vitro in the presence of inducing agents. Subsequently, the MI gel without ASCs was transplanted into rat cartilage defects in vivo for the regeneration of cartilage. After 3 months postimplantation, new cartilage tissue was successfully regenerated in a rat cartilage defect. All results indicated that the injectable self-healing host−guest hydrogels have important potential applications in cartilage injury repair.

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Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

Cited by 50 publications

References 106 publications

Hydrogel Electrolyte Enabled High‐Performance Flexible Aqueous Zinc Ion Energy Storage Systems toward Wearable Electronics

Hydrogel Electrolyte Enabled High‐Performance Flexible Aqueous Zinc Ion Energy Storage Systems toward Wearable Electronics

Advances in the Design of Phenylboronic Acid-Based Glucose-Sensitive Hydrogels

Building a Poly(amino acid)/Chitosan-Based Self-Healing Hydrogel via Host–Guest Interaction for Cartilage Regeneration

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