Mechanism of Suppression of Blood Glucose Level by Calcium Alginate in Rats

Idota, Yoko; Katō, Takako; Shiragami, Kazuyo; Koike, Mariko; Yokoyama, Akari; Takahashi, H.; Yano, Kentarô; Ogihara, Takuo

doi:10.1248/bpb.b18-00155

Cited by 14 publications

(19 citation statements)

References 30 publications

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“…Recently, we reported that Ca-Alg reduces absorption and promotes excretion of both strontium (Sr) and cesium (Cs), whereas Na-Alg is effective only for Sr. 20) In addition, we investigated the relationship between the physical parameters of various metal ions and the binding affinity of these metal ions for Alg. 21) Moreover, we found that Ca-Alg suppressed the elevation of blood glucose levels after ingestion of starch in rats and humans by inhibiting the degradation of maltose to glucose by α-glucosidase. 22,23) Moreover, we reported the blood Cho-lowering effect of Ca-Alg in rats.…”

Section: Introductionmentioning

confidence: 82%

Reduction Effect of Calcium Alginate on Blood Triglyceride Levels Causing the Inhibition of Hepatic and Total Body Accumulation of Fat in Rats

Kasahara

Katō

Idota

et al. 2019

Biological & Pharmaceutical Bulletin

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In this study, rats were fed a high-fat diet containing calcium alginate (Ca-Alg) for 5 weeks to examine the effects of Ca-Alg on lipid metabolism including triglyceride (TG) levels in the blood. We also investigated the mechanism of the TG-reducing effect of Alg in vitro. Rats were randomized into 5 groups: high-fat diet group (14% (w/w) lard, HF); three Ca-Alg-containing diet groups (2.5, 5 or 10% (w/w) Ca-Alg) and a resistant maltodextrin (RMD) diet group as a positive control (with 5% (w/w) RMD). The 10% Ca-Alg group showed a significant reduction of body weight increase from the 7th day. In addition, the increase of TG in blood was significantly suppressed, and the amount of TG excreted in feces was increased. Increase of body fat mass was in the order HF > RMD > Ca-Alg 2.5% > Ca-Alg 5% > Ca-Alg 10%, while the total weight of the extracted fat tissues was significantly reduced in the RMD, 5% and 10% Ca-Alg groups. Hepatic pathology showed clear circular vacuoles apparently representing TG accumulation in the HF group, while fewer vacuoles were seen in the Ca-Alg groups. The results of in vitro experiments indicated that Ca-Alg does not directly inhibit lipase activity, but may suppress absorption of TG by forming non-absorbable macromolecular micelles containing TG. These results suggest that Ca-Alg promotes excretion and suppresses absorption of TG, leading to reduced blood TG levels, and decreased hepatic and total body accumulation of fat. The findings should be helpful for designing future clinical trials.

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Section: Introductionmentioning

confidence: 82%

Reduction Effect of Calcium Alginate on Blood Triglyceride Levels Causing the Inhibition of Hepatic and Total Body Accumulation of Fat in Rats

Kasahara

Katō

Idota

et al. 2019

Biological & Pharmaceutical Bulletin

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“…21) We also reported that Ca-Alg has a blood cholesterol-lowering effect in rats 22) by suppressing bile acid reabsorption in the gastrointestinal tract and promoting catabolism of cholesterol to bile acid in the liver. 22) Moreover, we have investigated the mechanism of this effect, and established that Ca-Alg inhibits the degradation of starch into glucose in the gastrointestinal tract by inhibiting α-glucosidase activity. 23) In that report, it was established that the α-glucosidase-inhibitory effect of Ca-Alg is greater than that of Na-Alg.…”

mentioning

confidence: 83%

“…22) Moreover, we have investigated the mechanism of this effect, and established that Ca-Alg inhibits the degradation of starch into glucose in the gastrointestinal tract by inhibiting α-glucosidase activity. 23) In that report, it was established that the α-glucosidase-inhibitory effect of Ca-Alg is greater than that of Na-Alg. It has been reported elsewhere that the rise in blood glucose level after ingestion of curry and rice was sup-pressed by Ca-Alg in adult males, 24) and some clinical reports have mentioned the use of Ca-Alg.…”

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confidence: 99%

“…In the present work, in order to confirm the efficacy of Ca-Alg, we conducted a prospective, randomized, double-blind, 3-group, 3-phase crossover study to examine the effect of Ca-Alg on the postprandial increase of blood glucose in healthy Japanese adult subjects. We focused on udon, a traditional Japanese noodle, and measured blood glucose levels after ingestion of udon alone, and udon containing 5 or 8% Ca-Alg (supplementation levels were chosen based on our previous study of the optimum amount and particle size of Ca-Alg in rats 23) ). We also examined the effect of Ca-Alg on other chemical parameters in plasma or serum such as insulin (IRI), total cholesterol (T-Cho), high density lipoprotein cholesterol (HDL-Cho), low density lipoprotein cholesterol (LDL-Cho), triglyceride (TG), uric acid (UA), urea nitrogen (BUN) and calcium (Ca) levels.…”

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confidence: 99%

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Randomized, Double-Blind, Crossover Clinical Trial of the Effect of Calcium Alginate in Noodles on Postprandial Blood Glucose Level

Katō

Idota

Shiragami

et al. 2018

Biological & Pharmaceutical Bulletin

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We conducted a prospective, randomized, double-blind, 3-group, 3-phase crossover study to evaluate the effect of calcium alginate (Ca-Alg) on the postprandial increase of blood glucose in 15 healthy adult subjects who were given udon noodles containing or not containing Ca-Alg (5 or 8%). The value of ΔC (difference between the maximum (C) and pre-feeding (C) blood glucose levels) was significantly reduced in both Ca-Alg groups, and the area under the blood glucose level-time curve over 120 min (ΔAUC, with C as the baseline) was also significantly reduced. Thus, supplementation of noodles with Ca-Alg significantly suppressed both the peak postprandial blood glucose level and the total amount of glucose absorption. Blood calcium (Ca) concentration was significantly increased at 120 min after ingestion, but there was no marked change of other parameter values. A questionnaire indicated that addition of Ca-Alg did not affect the acceptability of the noodles. These results indicate that Ca-Alg might a useful food additive for helping to prevent lifestyle-related diseases without adversely affecting individual eating habits.

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“…Diabetics may develop serious complications such as retinopathy, nephropathy and neuropathy, in addition to myocardial infarction, cerebral infarction and so on [27,30], even though the initial subjective symptoms may be minor. Ca-Alg is known to suppress the postprandial increase of blood glucose, and therefore may be helpful in preventing lifestyle-related diseases such as diabetes.…”

Section: Suppression Of Postprandial Blood Glucose Levelmentioning

confidence: 99%

Pharmacological Effects and Utility as a Food Additive of Calcium Alginate

Kasahara¹,

Idota²,

Fukai³

et al. 2020

Alginates - Recent Uses of This Natural Polymer

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Here we review the physiological effects of the calcium salt of alginate (Ca-Alg), focusing on our own work. First, we found that Ca-Alg promotes the excretion and decreases the absorption of various metals, and does so more effectively than sodium alginate (Na-Alg). Ca-Alg also reduced plasma cholesterol (Cho) in rats fed a high-Cho diet for 2 weeks. This was considered to be due to reduced intestinal reabsorption of bile acid, resulting from the binding of Ca-Alg and bile acid; this induces an increase of bile acid synthesis from Cho in the liver, leading to a decrease in Cho in plasma. The increase of blood triglyceride (TG) levels in rats fed a highfat diet for 5 weeks was significantly suppressed by Ca-Alg, leading to decreased fat accumulation in the liver and whole body. Ca-Alg in food was also effective in suppressing the postprandial increase of blood glucose level in rats and humans. An in vitro study suggested that Ca-Alg inhibits the interaction between α-glucosidase and its substrate maltose. In conclusion, Ca-Alg has a number of beneficial effects as a functional food ingredient, and is expected to be a safe and effective food additive for long-term use.

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Mechanism of Suppression of Blood Glucose Level by Calcium Alginate in Rats

Cited by 14 publications

References 30 publications

Reduction Effect of Calcium Alginate on Blood Triglyceride Levels Causing the Inhibition of Hepatic and Total Body Accumulation of Fat in Rats

Reduction Effect of Calcium Alginate on Blood Triglyceride Levels Causing the Inhibition of Hepatic and Total Body Accumulation of Fat in Rats

Randomized, Double-Blind, Crossover Clinical Trial of the Effect of Calcium Alginate in Noodles on Postprandial Blood Glucose Level

Pharmacological Effects and Utility as a Food Additive of Calcium Alginate

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