Mechanism of the CNS-mediated pressor response to intracerebroventricular injection of noradrenaline in unanaesthetized rats

Corrêa, Fernando Morgan de Aguiar; Macro, Idalina A.S.; Peres-Polon, Vera Lúcia; Antunes‐Rodrigues, José

doi:10.1016/0028-3908(85)90033-4

Cited by 31 publications

(15 citation statements)

References 16 publications

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“…At this dose, d(CH 2 ) 5 Tyr(Me)AVP was shown to inhibit the vasopressinergic component of pressor responses to either intracerebroventricular or intracortical microinjection of noradrenaline (Corrêa et al, 1985;Fernandez et al, 2003), or the intraseptal injection of acetylcholine (Peres-Polon and Corrêa, 1994). The pretreatment with d(CH 2 ) 5 -Tyr(Me)AVP did not change the pressor response to EE of the MPFC, thus ruling out involvement of the vasopressinergic system in this response.…”

Section: Discussionmentioning

confidence: 93%

“…Classically, stimuli that promote vasopressin release are plasma osmolality elevation, blood volume reduction, blood pressure decrease, increased circulating angiotensin II levels, various stressors, fever and pain (Cunningham and Sawchenko, 1991;Share, 1996). Intracerebral injection of catecholamines (Hoffman, 1979;Corrêa et al, 1985;Corrêa and Peres-Polon, 1995), acetylcholine (Peres-Polon and Corrêa, 1994), or L-glutamate was reported to elicit pressor responses in rats, which are consequent to acute vasopressin release. Fernandes et al (2003) have demonstrated an important Fig.…”

Section: Discussionmentioning

confidence: 97%

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Pressor effects of electrical stimulation of medial prefrontal cortex in unanesthetized rats

Tavares

Antunes‐Rodrigues

Corrêa

2004

J of Neuroscience Research

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The medial prefrontal cortex (MPFC) is involved in central nervous system (CNS)-mediated cardiovascular modulation. We compared the cardiovascular effects of electrical stimulation (EE) of the MPFC in unanesthetized rats to those observed after stimulation of the same area in urethane-anesthetized rats. Electrical stimulation (35, 106, 177, 247, 318, and 389 microA rms/10 sec, 60-Hz sine wave) of the MPFC of urethane-anesthetized rats caused depressor responses of stimulus-related intensity. The cardiovascular response to electrical stimulation of the MPFC in unanesthetized rats was characterized by stimulus-related pressor responses. No significant heart rate changes were observed during the EE period in any case. The pressor response to electrical stimulation (106 microA rms/10 sec, 60-Hz sine wave) of the MPFC was not affected by intravenous pretreatment with the vasopressin antagonist dTyr(CH(2))(5)(Me)AVP (50 microg/kg, intravenously), by hypophysectomy, or by intravenous pretreatment with the angiotensin II antagonist losartan (1 mg/kg, intravenously). The pressor response was blocked by intravenous pretreatment with the ganglionic blocker mecamylamine (2 mg/kg, intravenously) but was not affected by adrenal demedullation, thus suggesting involvement of the neural component of the sympathetic nervous system without a major involvement of its hormonal component. Our results confirmed the occurrence of depressor responses after electrical stimulation of the MPFC in urethane-anesthetized rats and evidenced that only pressor responses are observed after its stimulation in unanesthetized rats. The fact that the pressor response to the stimulation of the MPFC was blocked by a ganglioplegic suggests that the MPFC has functional excitatory actions over the sympathetic nervous system.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 97%

Pressor effects of electrical stimulation of medial prefrontal cortex in unanesthetized rats

Tavares

Antunes‐Rodrigues

Corrêa

2004

J of Neuroscience Research

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“…Similar increase in the pressor responses to centrally injected NA under ganglion blockade was reported after i.c.v. (Corrêa et al, 1985) or intracortical (Fernandes et al, 2003) injection of NA in unanesthetized rats, suggesting humoral mediation. Under those conditions, the pressor effect of the central injection of NA was reported to be caused by vasopressin release into the circulation.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular responses to noradrenaline microinjection in the ventrolateral periaqueductal gray of unanesthetized rats

Pelosi

Tavares

Antunes‐Rodrigues

et al. 2007

J of Neuroscience Research

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The periaqueductal gray area (PAG) is a mesencephalic area involved in cardiovascular modulation. Noradrenaline (NA), a neurotransmitter involved in central blood pressure control, is present in the rat PAG. We report here on the cardiovascular effects caused by NA microinjection into the ventrolateral PAG (vlPAG) of unanesthetized rats and the peripheral mechanism involved in their mediation. NA microinjection in the vlPAG of unanesthetized rats evoked dose-related pressor and bradycardiac responses. No significant cardiovascular responses were observed in urethane-anesthetized rats. The pressor response was potentiated by pretreatment with the ganglion blocker pentolinium (5 or 10 mg/kg, intravenously). Pretreatment with the vasopressin antagonist dTyr(CH2)5 (Me)AVP (50 microg/kg, intravenously) blocked the pressor response evoked by the NA microinjection into the vlPAG. Additionally, circulating vasopressin content was found to be significantly increased after NA microinjection in the vlPAG. The results suggest that activation of noradrenergic synapses within the vlPAG modulates vasopressin release in unanesthetized rats.

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“…O pentolínio causou potencialização semelhante em respostas pressoras causadas pela microinjeção de NA em outras regiões do cérebro, sugerindo o envolvimento de uma mediação humoral. Outros estudos do nosso grupo mostraram que o aumento da pressão arterial e queda na frequência cardíaca causado pela microinjeção de NA em diversas regiões do cérebro foi mediado por liberação de vasopressina (CORREA et al, 1985;FERNANDES et al, 2003;PELOSI e CORREA, 2005;SCOPINHO et al, 2006;CRESTANI et al, 2007;PELOSI et al, 2008;BUSNARDO et al, 2009a).…”

Section: Discussionunclassified

“…A dose de 50 µg/Kg (i.v.) foi escolhida tendo-se como referência experimentos descritos na literatura (CORREA et al, 1985;FERNANDES et al, 2003;TAVARES e DE AGUIAR CORREA, 2003).…”

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Função da neurotransmissão noradrenérgica do núcleo medial da amígdala na modulação do sistema cardiovascular em ratos

Fortaleza¹

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Mechanism of the CNS-mediated pressor response to intracerebroventricular injection of noradrenaline in unanaesthetized rats

Cited by 31 publications

References 16 publications

Pressor effects of electrical stimulation of medial prefrontal cortex in unanesthetized rats

Pressor effects of electrical stimulation of medial prefrontal cortex in unanesthetized rats

Cardiovascular responses to noradrenaline microinjection in the ventrolateral periaqueductal gray of unanesthetized rats

Função da neurotransmissão noradrenérgica do núcleo medial da amígdala na modulação do sistema cardiovascular em ratos

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