Mechanism of the Effect of Ionizing Radiation on Sodium Uptake by Human Erythrocytes

Shapiro, Barry A.; Kollmann, George; Asnen, Joel N.

doi:10.2307/3571821

Cited by 67 publications

(5 citation statements)

References 10 publications

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“…of membrane protein following whole-body y-irradiation (13) . Although this reduction of 15% is statistically insignificant, it is similar to that reported for other irradiated systems (4,14).…”

Section: B Is the Irradiation-stimulated Uptake Of Amino Acids Limitsupporting

confidence: 88%

EFFECTS OF WHOLE-BODY AND X- AND $gamma$-IRRADIATION ON THE BIOSYNTHESIS OF CERTAIN SERUM PROTEINS. Progress Report, September 1, 1971--August 31, 1972.

Neuhaus¹

1972

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Section: B Is the Irradiation-stimulated Uptake Of Amino Acids Limitsupporting

confidence: 88%

EFFECTS OF WHOLE-BODY AND X- AND $gamma$-IRRADIATION ON THE BIOSYNTHESIS OF CERTAIN SERUM PROTEINS. Progress Report, September 1, 1971--August 31, 1972.

Neuhaus¹

1972

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“…These results indicate that exogenous GSH protects the membranous structures of the acinar cells against the early stages of radiation injury . It has been proposed that the most radiosensitive site of these membranous elements is membrane-binding SH (Archer and Wills 1973) and that GSH or other SH compounds act as radioprotectors by scavenging free radicals or supplying hydrogen to prevent oxidative injury in the membranes (Shapiro et al 1966) . The radioprotective effect of GSH has also been reported to be due to inhibiting peroxidation of the cell membrane (Konings et al 1979) .…”

Section: Discussionmentioning

confidence: 99%

Radioprotective Effect of Exogenous Glutathione on Rat Parotid Glands

Arima

Shiba

1992

International Journal of Radiation Biology

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The prophylactic effect of glutathione (GSH) on radiation injury in rat parotid glands was investigated. GSH was administered to male Wistar rats i.p. 15 min prior to irradiation. The necrosis index (NI) of the glands was determined histologically 24 h after a single dose of 15, 30, or 60 Gy. Total amylase activity, total protein content and wet weight of the glands were measured 30, 60 and 90 days after irradiation. Administration of GSH prior to radiation minimized acute and chronic radiation injuries as a function of the GSH dose: i.e. reduction of NI and prevention of the decrease in total amylase activity, total protein content and gland weight. The intraglandular level of non-protein-bound thiols (NPSH) and GSH increased significantly after i.p. administration of GSH, whether or not the glands were irradiated. An autoradiographic study revealed that i.p.-administered 35S-GSH was actively taken up by the glandular parenchyma, especially in the acini and ducts. It was shown that elevation of the intraglandular level of NPSH after exogenous administration of GSH protected the parotid glands from radiation injury in the rat.

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“…Одним из проявлений радиационного повреждения плазматических мембран является усиление выхода внутриклеточного калия [3,4]. В качестве одной из основных причин нарушения проницаемости мембран для од новалентных катионов в настоящее время рассматривается изменение структуры белковых молекул, обусловленное окислением сульфгидриль ных групп при воздействии радиации [5][6][7]. Вместе с тем, существуют предположения о том, что выход ионов калия из облученных клеток определяется радиационной модификацией физических свойств липицной фазы, в частности, ее полярности и микровязкости [2,8,9].…”

unclassified

Changes of the erythrocyte membrane permeability for potassium under the influence of radiation

et al. 1994

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Исследовали влияние электронов с энергией 5 МэВ на проницаемость мембран эрит роцитов для ионов К +. С использованием перехватчиков продуктов радиолиза воды и SH-активных соединений, показано, что радиационное нарушение транспорта калия связано с повреждением сульфгидрильных групп белков гидроксильными радикалами.

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Mechanism of the Effect of Ionizing Radiation on Sodium Uptake by Human Erythrocytes

Cited by 67 publications

References 10 publications

EFFECTS OF WHOLE-BODY AND X- AND $gamma$-IRRADIATION ON THE BIOSYNTHESIS OF CERTAIN SERUM PROTEINS. Progress Report, September 1, 1971--August 31, 1972.

EFFECTS OF WHOLE-BODY AND X- AND $gamma$-IRRADIATION ON THE BIOSYNTHESIS OF CERTAIN SERUM PROTEINS. Progress Report, September 1, 1971--August 31, 1972.

Radioprotective Effect of Exogenous Glutathione on Rat Parotid Glands

Changes of the erythrocyte membrane permeability for potassium under the influence of radiation

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