Mechanism of traumatic retinal detachment in blunt impact: A finite element study

Liu, Xiaoyu; Wang, Lizhen; Wang, Chao; Sun, Ganyun; Liu, Songyang; Fan, Yubo

doi:10.1016/j.jbiomech.2013.02.006

Cited by 62 publications

(31 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, in the latter case, finite-element models have been developed in an attempt to explain pathogenic mechanisms of blast or shaken baby-induced retinal trauma, while modeling the vitreous as a homogeneous viscoelastic material. [43][44][45] Because the structural organization of the vitreous and the vitreoretinal interface also can affect the retina, 2 incorporating anisotropic collagen alignment and orientation data in the vitreous could aid in improving the biological accuracy and predictive ability of such simulations.…”

Section: Quantitative Polarized Light Imaging Captures Global Patternmentioning

confidence: 99%

Quantitative Imaging of Enzymatic Vitreolysis-Induced Fiber Remodeling

Filas

Shah

Zhang

et al. 2014

Investigative Ophthalmology & Visual Science

View full text Add to dashboard Cite

Proteoglycan loss due to enzymatic vitreolysis differentially increases fiber alignment at locations where tractions are most common. We hypothesize that a similar mechanism leads to retinal complications during age-related vitreous degeneration. Structural changes to the entire vitreous body (as opposed to the vitreoretinal interface alone) should be evaluated during preclinical testing of pharmacological vitreolysis candidates.

show abstract

Section: Quantitative Polarized Light Imaging Captures Global Patternmentioning

confidence: 99%

Quantitative Imaging of Enzymatic Vitreolysis-Induced Fiber Remodeling

Filas

Shah

Zhang

et al. 2014

Investigative Ophthalmology & Visual Science

View full text Add to dashboard Cite

show abstract

“…The work presented in this chapter is concerned only with the determination of shape of retinal blister and an analysis of its sensitivity to the elastic modulus and moment of inertia and the intraocular pressure. Results for modulus as a mechanism to close the detached area suggest the influence of the parameters of the retinal on its effectiveness with regard to closure and minimizing induced ocular pressure [7] [8]. We do not claim that great numerical accuracy should be attributed to the calculated value of modulus, since the real retina, though possessing elastic properties, is not a homogenous structure.…”

Section: Resultsmentioning

confidence: 94%

Mathematical Modeling of Exudative Retinal Detachment

Avtar¹,

Srivastava²

2017

View full text Add to dashboard Cite

A simple mathematical model for the exudative retinal detachment has been developed. The model takes into consideration a typical retinal blister with unknown shape and the fluid flow caused by its accumulation in the subretinal space through the fluid-leakage into the subretinal space from the choriocapillar is across the outer blood-retina barrier described by Darcy's law. The theory of bending beams is applied to model the deformation of the retinal blister. The boundary value problem describing the retinal deformation in dimensionless form is solved using the perturbation method. The computational results for the retinal deformation are presented through graphs to illustrate the sensitivity of the deformation to the elastic modulus, the moment of inertia and intraocular pressure and discussed.

show abstract

“…This model has been validated to predict globe rupture resulting from blunt impacts by different objects (Liu et al 2013). The eye model included the structures of cornea, sclera, lens, ciliary body, zonules, aqueous and vitreous body.…”

Section: Modelling Of the Human Eyementioning

confidence: 99%

“…Stitzel et al (2002) predicted globe rupture caused by blunt impact using finite element analysis, which was validated by 22 matched experiments. There have been more recent simulation studies conducted on ocular injuries related to lens injury (Stitzel et al 2005), optic nerve damage (Cirovic et al 2006), globe rupture after PRK and LASIK (Mousavi et al 2012), retinal damage in abusive head trauma (Hans et al 2009;Rangarajan et al 2009) and traumatic retinal detachment (Rossi et al 2011;Liu et al 2013). The current work aimed to develop a blast event model with an implanted eye to predict globe rupture caused by primary blast effects.…”

Section: Introductionmentioning

confidence: 99%

Prediction of globe rupture caused by primary blast: a finite element analysis

Liu

Wang

et al. 2014

Computer Methods in Biomechanics and Biomedical Engineering

Self Cite

View full text Add to dashboard Cite

Although a human eye comprises less than 0.1% of the frontal body surface area, injuries to the eye are found to be disproportionally common in survivors of explosions. This study aimed to introduce a Lagrangian-Eulerian coupling model to predict globe rupture resulting from primary blast effect. A finite element model of a human eye was created using Lagrangian mesh. An explosive and its surrounding air domain were modelled using Eulerian mesh. Coupling the two models allowed simulating the blast wave generation, propagation and interaction with the eye. The results showed that the peak overpressures caused by blast wave on the corneal apex are 2080, 932.1 and 487.3 kPa for the victim distances of 0.75, 1.0 and 1.25 m, respectively. Higher stress occurred at the limbus, where the peaks for the three victim distances are 25.5, 14.1 and 6.4 MPa. The overpressure threshold of globe rupture was determined as 2000 kPa in a small-scale explosion. The findings would provide insights into the mechanism of primary blast-induced ocular injuries.

show abstract

Mechanism of traumatic retinal detachment in blunt impact: A finite element study

Cited by 62 publications

References 27 publications

Quantitative Imaging of Enzymatic Vitreolysis-Induced Fiber Remodeling

Quantitative Imaging of Enzymatic Vitreolysis-Induced Fiber Remodeling

Mathematical Modeling of Exudative Retinal Detachment

Prediction of globe rupture caused by primary blast: a finite element analysis

Contact Info

Product

Resources

About