Mechanism of vasculitis and aneurysms in Kawasaki disease: role of nitric oxide

Adewuya, Oladapo; Irie, Yoshihito; Bian, Ka; Onigu-Otite, Edore; Murad, Ferid

doi:10.1016/s1089-8603(02)00125-8

Cited by 21 publications

(13 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MMPs, neutrophil elastase) have been reported in this condition [78]. Another pathway via which Kawasaki disease may trigger aneurysm formation involves induction of NO and its detrimental metabolite, peroxynitrite [79].…”

Section: Ectasia: Local or Generalized Condition?mentioning

confidence: 81%

Pathogenetic mechanisms of coronary ectasia

Antoniadis

Chatzizisis

Giannoglou

2008

International Journal of Cardiology

188

205

View full text Add to dashboard Cite

Section: Ectasia: Local or Generalized Condition?mentioning

confidence: 81%

Pathogenetic mechanisms of coronary ectasia

Antoniadis

Chatzizisis

Giannoglou

2008

International Journal of Cardiology

188

205

View full text Add to dashboard Cite

“…There have been several articles suggesting the important role of NO in KD [1,6,10,22,23]. All of them including ours [10], however, have not measured NO itself but proved increased NO production indirectly, i.e., increased expression of iNOS [6,23] or increased NO metabolites (NOx:…”

Section: Discussionmentioning

confidence: 94%

“…) in patients' plasma and urine [10,22] or increased nytrotyrosine (end product of NO's toxic effects) in coronary arterioles in mice models of KD [1]. Although the cause of KD remains unknown, recent study suggests that activation of the immune system characterized by increased production of inflammatory cytokines such as TNF-α, IL-1, 6, 8 [4], MCP-1 [20], and VEGF [8] is a central feature [13].…”

Section: Discussionmentioning

confidence: 99%

Increased nitric oxide production by neutrophils in early stage of Kawasaki disease

et al. 2008

View full text Add to dashboard Cite

Recent observations suggested that nitric oxide (NO) has a role in triggering the early endothelial dysfunction in Kawasaki disease (KD). We investigated the amount of NO in conjunction with reactive oxygen species (ROS) produced by neutrophils in children with acute KD by a newly developed flow cytometric analysis. Forty children with acute KD (n = 14), non-KD febrile disease (n = 14), and afebrile control (n = 12) were enrolled (age, 3 to 88 months). Neutrophils in KD produced significantly higher amount of NO compared to others (p < 0.05). With regard to ROS, significant increase was not only found in KD but also in non-KD febrile children (p < 0.05 and p < 0.01, respectively). In KD patients, the amount of NO produced by neutrophils decreased after immunoglobulin (IVIG) treatment, while there was no significant change in ROS production. The amount of NO in KD patients also correlated well with the days from the onset. One patient who developed coronary arterial lesion showed the highest value of NO. In conclusion, neutrophils in acute KD generate both NO and ROS considerably, while NO production is exclusive in the early stage of KD before IVIG treatment. Abnormal immune system in KD might be characterized by an overproduction of NO, whereas the role of NO in endothelial damage remains to be elucidated.

show abstract

“…NO has both beneficial and nonbeneficial effects depending on site and concentration (51). Despite the ability to maintain vascular homeostasis, excess NO production under certain conditions may enhance the cellular stress, probably via peroxynitrite formation.…”

Section: Discussionmentioning

confidence: 99%