Mechanism of VKORC1 and VKORC1L1 signaling in the effects of sodium dehydroacetate on coagulation factors in rat hepatocytes

Effects of sodium dehydroacetate on broiler chicken bones

“…Huang et al indicated that DHA-Na may be a risk factor for disorders related to the cardiovascular system and exercise persistence in zebrafish ( Huang et al, 2021 a; Huang et al, 2021 b). We previously reported that DHA-Na induced coagulation disorder in rats and broiler chickens and identified the mechanisms underlying coagulation disorder via the inhibition of liver vitamin K epoxide reductase ( VKOR ) complex subunit 1 ( VKORC1 ) and VKORC1-like protein 1 ( VKORC1L1 ) activities ( Chen et al, 2021 , Xu et al, 2023 , Zhou et al, 2023 ).…”

“…In addition, warfarin exposure resulted in decreased bone density in lambs and rats ( Simon et al, 2002 ; Chen et al, 2021 ). Notably, warfarin and DHA-Na have similar structures and mechanism of causing bleeding; therefore, DHA-Na may interfere with bone health ( Pastoureau et al, 1993 , Zhou et al, 2023 ). As such, we believe that in broiler chickens, excessive DHA-Na use in feed has detrimental effects on bone health, potentially increasing leg disease prevalence and exacerbating relevant animal welfare and economic concerns.…”