Mechanism(s) of Modulation of Alcohol Consumption: Studies on the P and NP Rats

Lumeng, Lawrence; Li, Ting‐Kai; McBride, William J.; Murphy, James M.; Morzorati, Sandra L.; Froehlich, Janice C.

doi:10.1007/978-1-4612-4514-8_26

Cited by 7 publications

(3 citation statements)

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“…An application of a genetic selection approach has resulted in the derivation of several pairs of rat lines which demonstrate either very high or very low levels of voluntary alcohol consumption: the AA (Alko-Alcohol) and ANA (Alko-Nonalcohol) rat lines in Finland (Eriksson and Rusi, 1981), the UChA (low alcohol preference) and UChB (high alcohol preference) rat lines in Chili (Mardones, 1960;Mardones and Segozia-Riquelene, 1983), and the P (alcohol-preferring) and NP (alcohol-nonpreferring) and HAD and LAD rat lines in the United States (Li et al, 1979(Li et al, , 1981Lumeng et al, 1986Lumeng et al, , 1989). …”

Section: A Genetic Animal Model Of Alcoholismmentioning

confidence: 96%

“…There are a number of neurochemical characteristics within these systems that are associated with, and may be causally related to, differences in alcohol intake (Badia-Elder et al, 1999;Froehlich et al, 1998;Froehlich and Li, 1989, 1994Wand, 1996, 1997;Gong et al, 1997;Kimpel et al, 2003Kimpel et al, , 2007.…”

Section: Utility Of Rat Lines Selectively Bred For Differences In Alcmentioning

confidence: 97%

“…Rats of the P and NP lines have been wellcharacterized over the past 30 years and comparisons of the P and NP lines have resulted in the identification of a number of heritable behavioral and neurobiological characteristics which are associated with, and may be causally related to, differences in alcohol intake (Froehlich, 1995;Gong et al, 1997;Kurtz et al, 1996;Li et al, 1988aLi et al, , 1988bLi et al, , 1998Lumeng et al, 1989;Murphy et al, 1982Murphy et al, , 1987Stewart et al, 1992). These rat lines have also been used to screen pharmacotherapeutic agents that have the potential to reduce alcohol drinking and alcohol relapse (for review see Froehlich, 1995;Froehlich et al, 1987;.…”

Section: Utility Of Rat Lines Selectively Bred For Differences In Alcmentioning

confidence: 98%

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What Aspects of Human Alcohol Use Disorders Can Be Modeled Using Selectively Bred Rat Lines?

Froehlich

2010

Substance Use & Misuse

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The use of selective breeding to produce animal models for the study of alcohol abuse and alcoholism represents one of the major advances in the field of alcohol research. Rats selectively bred for alcohol preference and alcohol nonpreference have been useful to both preclinical and clinical investigators in the alcohol research community for studying the behavioral, neurobiological, and molecular basis of alcohol drinking, for identifying the genes that may contribute to the development of alcohol abuse and alcoholism, and for evaluating the utility of drugs aimed at reducing alcohol intake and preventing alcohol relapse. Rats selectively bred for alcohol preference (alcohol preferring or "P" line) have enhanced responsiveness to the low dose reinforcing effects of alcohol, less aversion to moderate/high doses of alcohol, and are able to develop tolerance to the aversive effects of alcohol more rapidly and to maintain tolerance longer than rats selectively bred for alcohol nonpreference (alcohol nonpreferring or "NP" line). The increased potency of low-dose alcohol as a reinforcer for P rats might be expected to foster and maintain alcohol drinking. Weaker aversion to the pharmacological effects of moderate/high doses of alcohol in the P line would allow P rats to drink more alcohol than NP rats before the postingestional effects become aversive. Rapid induction of tolerance to the aversive effects of alcohol with repeated bouts of voluntary alcohol drinking, as well as persistence of alcohol tolerance in rats of the P line might serve to maintain alcohol drinking. These are powerful mechanisms that may serve to promote and maintain a high alcohol drinking behavior. Although these rat lines have been used to address several characteristics of excessive alcohol consumption in humans, they have not yet been used to model several aspects of human alcohol use disorders. New applications of these selectively bred rat lines are discussed which may further our understanding of the factors contributing to alcohol abuse and alcoholism.

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Section: A Genetic Animal Model Of Alcoholismmentioning

confidence: 96%