Mechanism study and molecular design in controlled/“living” radical polymerization

Tu, Yingfeng; Cheng, Zhenping; Zhang, ZhengBiao; Zhu, Jian; Zhang, Wei; Zhou, Nianchen; Ni, Peihong; Zhu, Xiulin

doi:10.1007/s11426-010-4051-7

Cited by 7 publications

(4 citation statements)

References 159 publications

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“…Microwave-Assisted RAFT Polymerization Three reviews on microwave-assisted polymerization [65,98,99] and two reviews specifically on microwave-assisted RAFT polymerization [30,31] have appeared. The number of papers on …”

Section: Atrp-initiated Raft Polymerizationmentioning

confidence: 99%

“…[62] The process is also given substantial coverage in most recent reviews that, in part, relate to polymer synthesis, living or controlled polymerization or novel architectures. Some of those that include significant mention of RAFT polymerization include reviews on RDRP, [63] mechanism and reagent design, [11,64,65] click chemistry, [66][67][68][69][70][71][72] synthesis of telechelics, [73] the polymerization of carbazole-containing monomers, [74] N-vinyl-1,2,3-triazoles, [75] N-vinyl heterocycles, [76] fluoro-monomers, [77] and glycomonomers, [78][79][80] synthesis of metallopolymers, [81] conjugated block copolymers, [82] dye-functionalized polymers, [83] stimuliresponsive polymers, [84,85] complex architectures, [86,87] polyolefin blocks, [88] biopolymer-polymer conjugates and bioapplications, [59,[89][90][91][92][93] polysaccharide modification, [94,95] polymerization in heterogeneous media, [96,97] microwave-assisted polymerization, [65,98,99] industrial prospects for RDRP, [100,…”

Section: Introductionmentioning

confidence: 99%

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Living Radical Polymerization by the RAFT Process – A Third Update

2012

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This paper provides a third update to the review of reversible deactivation radical polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC(¼S)SR) by a mechanism of reversible addition-fragmentation chain transfer ( Chem. 2009Chem. , 62, 1402. This review cites over 700 publications that appeared during the period mid 2009 to early 2012 covering various aspects of RAFT polymerization which include reagent synthesis and properties, kinetics and mechanism of polymerization, novel polymer syntheses, and a diverse range of applications. This period has witnessed further significant developments, particularly in the areas of novel RAFT agents, techniques for end-group transformation, the production of micro/nanoparticles and modified surfaces, and biopolymer conjugates both for therapeutic and diagnostic applications.

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Section: Atrp-initiated Raft Polymerizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Living Radical Polymerization by the RAFT Process – A Third Update

2012

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“…The controlled/living radical polymerization (C/LRP) has attracted many attention due to its various promising potential applications for the tailor-made polymer architectures since the 1990s [1] . One of the driving forces behind the recent interest in control living free-radical procedures, such as nitroxide-mediated polymerization (NMP) [2] , atom transfer radical polymerization (ATRP) [3] , and reversible addition-fragmentation chain transfer (RAFT) [4] polymerization, has been demonstrated that these novel techniques provide an unprecedented opportunity for designing and controlling macromolecular architectures under mild reaction conditions.…”

Section: Introductionmentioning

confidence: 99%

Using Reversible Addition-Fragmentation Chain Transfer Polymerization to Synthesize Well-Defined Polymer

Bian

Qin

2013

AMR

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As an effective and versatile tool for production of functional polymer, RAFT polymerization has been successfully applied to the polymerization of block copolymers and other polymers of complex architectures with precisely controlled structure, molecular weight, and polydispersity. It has the ability to control polymerization of most monomers and has fine compatibility with reaction conditions. The present article summarized some of the features of the RAFT process, and reviewed the recent advances in the production of green polymers.

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“…Zhu et al summarized their achievements in controlled radical polymerizations [16], which is fundamental to develop new radical polymerization techniques, and an abundance of polymer materials with different topologies have been prepared through this technique. They specially focused on the molecule design and mechanism study in CRP, and the CRP initiated at different conditions.…”

mentioning

confidence: 99%

Focus on polymer chemistry papers in Science China Chemistry of the year 2010

2011

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The journal Science China Chemistry published 63 papers in polymer fields in 2010, leading to a percentage increase of 473% compared to the year 2008 and 70% to the year 2009, respectively (Figure 1). In this year, three polymer Special Topics were designed and published: Biomedical Polymer (Number 3) [1], Advances in Principles of Polymerization (Number 8) [2] and Highly Branched Polymers-Promising Architectural Macromolecules (Number 12) [3]. Several high qualified papers were published and great achievements have been obtained in the year 2010.The Special Topic of Biomedical Polymers was organized by Prof. GAO ChangYou and GU ZhongWei. According to these papers one knows that the applications of biomedical polymers are focusing on drug release [4-8] and gene delivery [9,10]. For the drug release system, a great number of materials can be utilized such as supermolecule, block copolymers, hyperbranched polymers, etc. Yan et al. synthesized a series of hyperbranched copolymers and explored their applications, especially in drug release [4,11,12].In their researches, two kinds of novel temperature-responsive hyperbranched multiarm copolymers were successfully synthesized via the atom transfer radical polymerization (ATRP). Poly(3-ethyl-3-(hydroxymethyl) oxetane) (HBPO) core and thermosensitive poly(N-isopropylacrylamide) (PNIPAM) arms were synthesized from NIPAM monomers by using a hyperbranched HBPO macroinitiator. Moreover, poly(L-lactide) (PLA) inner-shell and poly(ethylene glycol) (PEG) outer-shell with disulfide-linkages between the hydrophobic and hydrophilic moieties was developed as unimolecular micelles. The HBPO-star-PNIPAM self-assembled micelles showed much improved drug encapsulation efficiencies and temperature-dependent sustainable release behavior due to the special micellar structure. The micelles exhibited no apparent cytotoxicity against human HeLa cells. The H40-star-PLA-SS-PEG bioreducible unimolecular micelles were proved as promising carriers for the triggered intracellular delivery of hydrophobic anticancer drugs. Gu's review discussed peptide dendrimers synthesis and functionalization and their applications in biomedicine for drug release and gene delivery [13]. There are two main advantages of the peptide dendrimers, i.e. the size controllable synthesis even to nanometers and the good biocompatibility due to their similar properties as proteins. Therefore, the peptide dendrimers have received considerable attention in biomedicine. They also investigated a novel supramolecular nanoparticle, and studied the drug release behavior and the anti-tumor effects. The results demonstrate that the supramolecular nanoparticles are biocompatible and are promising carriers for drug delivery. Zhang et al. discussed several kinds of stimulus-responsive nanoparticles, including pH-responsive, temperature-responsive, lightresponsive, magnetic-responsive, ultrasound-responsive, pH/

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Mechanism study and molecular design in controlled/“living” radical polymerization

Cited by 7 publications

References 159 publications

Living Radical Polymerization by the RAFT Process – A Third Update

Living Radical Polymerization by the RAFT Process – A Third Update

Using Reversible Addition-Fragmentation Chain Transfer Polymerization to Synthesize Well-Defined Polymer

Focus on polymer chemistry papers in Science China Chemistry of the year 2010

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