2024
DOI: 10.3389/fimmu.2024.1359933
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Mechanism study of ubiquitination in T cell development and autoimmune disease

Hui Yu,
Wenyong Yang,
Min Cao
et al.

Abstract: T cells play critical role in multiple immune processes including antigen response, tumor immunity, inflammation, self-tolerance maintenance and autoimmune diseases et. Fetal liver or bone marrow-derived thymus-seeding progenitors (TSPs) settle in thymus and undergo T cell-lineage commitment, proliferation, T cell receptor (TCR) rearrangement, and thymic selections driven by microenvironment composed of thymic epithelial cells (TEC), dendritic cells (DC), macrophage and B cells, thus generating T cells with di… Show more

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