MECHANISM TOWARDS COMPENSATION OF LONG-TERM HEMOPOIETIC INJURY IN MICE AFTER 5 Gy TOTAL BODY IRRADIATION: SUPEROXIDE ANION PRODUCTION BY GRANULOCYTES

Gaitán, Soledad; Cuenllas, Elvira; Sancho, Pilar; Bueren, Juan A.; Tejero, C

doi:10.1016/b978-0-12-168561-4.50618-1

Cited by 2 publications

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“…Although in previous studies the number of mature blood cells was not highly affected in animals expressing a long-term bone marrow injury (Hendry 1985), few studies have been presented concerning the function of these cells (Gaitan et al . 1992) .…”

Section: Introductionmentioning

confidence: 95%

Residual Haematopoietic Damage in Adult and 8 Day-old Mice Exposed to 7 Gy of X-rays

Grande¹,

Gaitán²,

Tejero³

et al. 1993

International Journal of Radiation Biology

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Our experiments have focused on the analysis of residual haematopoietic damage in 8-day-old and 12-week-old mice X-irradiated with a single dose of 7 Gy. In the case of the adult mice, analysis of the femoral and splenic CFU-S, CFU-GM and BFU-E showed a persistent depletion of these haematopoietic progenitor cells after irradiation. In contrast, in 1-week-old irradiated mice, a progressive recovery of the femoral haematopoietic progenitors was observed, achieving essentially normal values 1 year after irradiation. The spleens of these mice, however, contained significantly less haematopoietic progenitors than the control group, mainly as a consequence of the size reduction of this organ. In the peripheral blood, normal cellularity values were observed in most cases, although in the adult group a decline in numbers or circulating cells was noted after the first year following irradiation. Long-term bone marrow cultures (LTBMCs) established 1 year after the irradiation of adult mice generated poor adherent layers, while confluent stromas were observed in flasks corresponding to 8-day-old irradiated mice. Analyses of the functional activity of granulocytes obtained from either the peripheral blood or LTBMCs revealed that both young and adult irradiated mice produced granulocytes generating high levels of superoxide anion, in relation to age-matched controls. This finding was correlated with a long-term microenvironmental activation which resulted in an overproduction of granulocyte-macrophage colony-stimulating factor.

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Section: Introductionmentioning

confidence: 95%

Residual Haematopoietic Damage in Adult and 8 Day-old Mice Exposed to 7 Gy of X-rays

Grande¹,

Gaitán²,

Tejero³

et al. 1993

International Journal of Radiation Biology

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“…Certain reports indicate increased levels of O 2 -in the granulocytes of mice subjected to total body irradiation (1). A wide range of compounds have been investigated in the recent past for their efficacy to protect against radiation damage (2).…”

Section: Introductionmentioning

confidence: 99%

Radioprotective effects of ocimum flavonoids on leukocyte oxidants and antioxidants in oral cancer

Kumarchandra¹,

Rao

Dinesh

et al. 2008

Indian J Clin Biochem

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MECHANISM TOWARDS COMPENSATION OF LONG-TERM HEMOPOIETIC INJURY IN MICE AFTER 5 Gy TOTAL BODY IRRADIATION: SUPEROXIDE ANION PRODUCTION BY GRANULOCYTES

Cited by 2 publications

References 0 publications

Residual Haematopoietic Damage in Adult and 8 Day-old Mice Exposed to 7 Gy of X-rays

Residual Haematopoietic Damage in Adult and 8 Day-old Mice Exposed to 7 Gy of X-rays

Radioprotective effects of ocimum flavonoids on leukocyte oxidants and antioxidants in oral cancer

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